Entity Details

Primary name MC4R_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP32245
EntryNameMC4R_HUMAN
FullNameMelanocortin receptor 4
TaxID9606
Evidenceevidence at protein level
Length332
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesMC4R

GO terms

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GOName
GO:0002024 diet induced thermogenesis
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004930 G protein-coupled receptor activity
GO:0004977 melanocortin receptor activity
GO:0004980 melanocyte-stimulating hormone receptor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006112 energy reserve metabolic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007631 feeding behavior
GO:0016021 integral component of membrane
GO:0017046 peptide hormone binding
GO:0019222 regulation of metabolic process
GO:0031625 ubiquitin protein ligase binding
GO:0042923 neuropeptide binding
GO:0045780 positive regulation of bone resorption
GO:2000252 negative regulation of feeding behavior
GO:2000821 regulation of grooming behavior

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000155 Melanocortin 4 receptorFamilyFamily
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR001671 Melanocortin/ACTH receptorFamilyFamily
IPR001908 Melanocortin receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Disease IDSourceNameDescription
601665 OMIMObesity (OBESITY)A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB11653 BremelanotideDrugbanksmall molecule
DB11700 SetmelanotideDrugbanksmall molecule