Entity Details

Primary name DDIT3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35638
EntryNameDDIT3_HUMAN
FullNameDNA damage-inducible transcript 3 protein
TaxID9606
Evidenceevidence at protein level
Length169
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesDDIT3

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001955 blood vessel maturation
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005770 late endosome
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006974 cellular response to DNA damage stimulus
GO:0006983 ER overload response
GO:0006986 response to unfolded protein
GO:0007605 sensory perception of sound
GO:0008134 transcription factor binding
GO:0008140 cAMP response element binding protein binding
GO:0009948 anterior/posterior axis specification
GO:0010506 regulation of autophagy
GO:0016055 Wnt signaling pathway
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032689 negative regulation of interferon-gamma production
GO:0032700 negative regulation of interleukin-17 production
GO:0032713 negative regulation of interleukin-4 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032792 negative regulation of CREB transcription factor activity
GO:0032993 protein-DNA complex
GO:0034976 response to endoplasmic reticulum stress
GO:0036488 CHOP-C/EBP complex
GO:0036499 PERK-mediated unfolded protein response
GO:0036500 ATF6-mediated unfolded protein response
GO:0042594 response to starvation
GO:0042803 protein homodimerization activity
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043522 leucine zipper domain binding
GO:0043525 positive regulation of neuron apoptotic process
GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress
GO:0045454 cell redox homeostasis
GO:0045599 negative regulation of fat cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051898 negative regulation of protein kinase B signaling
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0072655 establishment of protein localization to mitochondrion
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0120163 negative regulation of cold-induced thermogenesis
GO:0140416 transcription regulator inhibitor activity
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:1990442 intrinsic apoptotic signaling pathway in response to nitrosative stress
GO:1990617 CHOP-ATF4 complex
GO:1990622 CHOP-ATF3 complex
GO:2000016 negative regulation of determination of dorsal identity
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR004827 Basic-leucine zipper domainDomainDomain
IPR016670 DNA damage-inducible transcript 3FamilyFamily

Diseases

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Disease IDSourceNameDescription
613488 OMIMMyxoid liposarcoma (MXLIPO)A soft tissue tumor that tends to occur in the limbs (especially the thigh) of patients ranging in age from 35 to 55 years. It is defined by the presence of a hypocellular spindle cell proliferation set in a myxoid background, often with mucin pooling. Lipoblasts tend to be small and often monovacuolated and to cluster around vessels or at the periphery of the lesion. The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving DDIT3 has been found in a patient with malignant myxoid liposarcoma. Translocation t(12;16)(q13;p11) with FUS (PubMed:7503811).

Interactions

92 interactions

InteractorPartnerSourcesPublicationsLink
DDIT3_HUMANDHB14_HUMANBioGRID, HPRD, IntAct16189514 25416956 27107012 32296183 details
DDIT3_HUMANMCMBP_HUMANBioGRID, HPRD, IntAct16189514 32296183 details
DDIT3_HUMANSPOP_HUMANBioGRID, HPRD, IntAct16189514 24990631 details
DDIT3_HUMANBATF_HUMANBioGRID, DIP, HPIDb, HPRD, IntAct, UniProt16189514 18330356 20102225 23661758 27107012 details
DDIT3_HUMANCEBPG_HUMANBioGRID, HPIDb, HPRD, IntAct, UniProt12618752 16189514 20102225 20211142 23661758 25416956 details
DDIT3_HUMANDDIT3_HUMANBioGRID, IntAct, UniProt20562859 23661758 details
DDIT3_HUMANTEDC1_HUMANBioGRID, DIP, IntAct18330356 20562859 details
DDIT3_HUMANDBP_HUMANBioGRID, IntAct, UniProt21988832 23661758 details
DDIT3_HUMANTHRB_HUMANBioGRID, IntAct21988832 details
DDIT3_HUMANEP300_HUMANBioGRID, IntAct17872950 21988832 24270407 details
DDIT3_HUMANNEMO_HUMANBioGRID, IntAct21988832 details
DDIT3_HUMANIDD_HUMANBioGRID, IntAct21988832 details
DDIT3_HUMANRPAC2_HUMANBioGRID, IntAct21988832 details
DDIT3_HUMANIMA1_HUMANBioGRID, IntAct21988832 details
DDIT3_HUMANCDK6_HUMANBioGRID, IntAct22094256 details
DDIT3_HUMANVP37C_HUMANBioGRID, IntAct25416956 32296183 details
DDIT3_HUMANSNPC5_HUMANBioGRID, IntAct25416956 details
DDIT3_HUMANFOSL2_HUMANBioGRID, HPIDb, IntAct20102225 25416956 27107012 32296183 details
DDIT3_HUMANZBT25_HUMANBioGRID, IntAct25416956 details
DDIT3_HUMANRBTN2_HUMANBioGRID, IntAct25416956 details
DDIT3_HUMANCC153_HUMANBioGRID, IntAct25416956 details
DDIT3_HUMANZC3HE_HUMANBioGRID, IntAct25416956 details
DDIT3_HUMANEMSY_HUMANBioGRID, IntAct25416956 32296183 details
DDIT3_HUMANATPF2_HUMANBioGRID, IntAct25416956 details
DDIT3_HUMANBATF3_HUMANBioGRID, HPIDb, IntAct, UniProt20102225 20211142 23661758 25416956 32296183 details
DDIT3_HUMANAMOL2_HUMANBioGRID, IntAct25416956 details
DDIT3_HUMANFOS_HUMANBioGRID, HPIDb, HPRD, IntAct, UniProt10523647 20102225 23661758 26264872 29997244 31467278 32814053 details
DDIT3_HUMANATF3_HUMANBioGRID, HPIDb, HPRD, IntAct, UniProt20102225 20211142 23661758 26264872 27107012 29997244 31467278 32814053 8622660 details
DDIT3_HUMANBACH1_HUMANBioGRID, HPIDb, UniProt20102225 23661758 details
DDIT3_HUMANNFIL3_HUMANBioGRID, HPIDb, UniProt20102225 23661758 details
DDIT3_HUMANCEBPA_HUMANBioGRID, HPIDb, UniProt20102225 23661758 27555288 details
DDIT3_HUMANCEBPB_HUMANBioGRID, HPIDb, HPRD12706815 1547942 20102225 20562859 8662954 details
DDIT3_HUMANCEBPD_HUMANHPIDb20102225 details
DDIT3_HUMANATF4_HUMANBioGRID, DIP, HPIDb, HPRD, UniProt12805554 18330356 20102225 23661758 details
DDIT3_HUMANCREB3_HUMANBioGRID, HPIDb, UniProt20102225 23661758 details
DDIT3_HUMANHLF_HUMANHPIDb, UniProt20102225 23661758 details
DDIT3_HUMANATF2_HUMANBioGRID, HPIDb, UniProt20102225 23661758 details
DDIT3_HUMANATF7_HUMANHPIDb20102225 details
DDIT3_HUMANJUNB_HUMANBioGRID, HPIDb, UniProt20102225 23661758 details
DDIT3_HUMANPCM1_HUMANBioGRID, IntAct27107012 details
DDIT3_HUMANEFC4B_HUMANBioGRID, IntAct32296183 details
DDIT3_HUMANTHIOM_HUMANBioGRID, IntAct32296183 details
DDIT3_HUMANJDP2_HUMANBioGRID, IntAct32296183 details
DDIT3_HUMANCRBL2_HUMANBioGRID, IntAct32296183 details
DDIT3_HUMANTNF12_HUMANBioGRID, IntAct25416956 32296183 details
DDIT3_HUMANTXND2_HUMANBioGRID, IntAct32296183 details
DDIT3_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
DDIT3_HUMANGIPC1_HUMANBioGRID, DIP18330356 details
DDIT3_HUMANNF2L2_HUMANIntAct32911434 details
DDIT3_HUMANGFAP_HUMANIntAct32814053 details
DDIT3_HUMANJPH3_HUMANIntAct32814053 details
DDIT3_HUMANCEBPE_HUMANBioGRID, HPRD, IntAct, UniProt15588942 20211142 23661758 details
DDIT3_HUMANBATF2_HUMANBioGRID, UniProt23661758 details
DDIT3_HUMANCR3L1_HUMANBioGRID, UniProt23661758 details
DDIT3_HUMANJUN_HUMANBioGRID, HPRD, UniProt10523647 23661758 details
DDIT3_HUMANFOSL1_HUMANBioGRID, UniProt23661758 details
DDIT3_HUMANMAFG_HUMANBioGRID, UniProt23661758 details
DDIT3_HUMANMAFF_HUMANBioGRID, UniProt23661758 details
DDIT3_HUMANBACH2_HUMANBioGRID, UniProt23661758 details
DDIT3_HUMANSSX3_HUMANBioGRID, IntAct20211142 details
DDIT3_HUMANRAI1_HUMANBioGRID, IntAct20211142 details
DDIT3_HUMANHXA5_HUMANBioGRID, IntAct20211142 details
DDIT3_HUMANZSC31_HUMANBioGRID, IntAct20211142 details
DDIT3_HUMANCSK21_HUMANBioGRID, HPRD12876286 details
DDIT3_HUMANJUND_HUMANBioGRID, HPRD10523647 details
DDIT3_HUMANRS3A_HUMANBioGRID, HPRD10713066 details
DDIT3_HUMANMK14_HUMANBioGRID, HPRD8650547 details
DDIT3_HUMANSRA1_HUMANBioGRID20398657 details
DDIT3_HUMANEPAS1_HUMANBioGRID23661758 details
DDIT3_HUMANGP1BA_HUMANBioGRID21988832 details
DDIT3_HUMANRPC22_HUMANBioGRID21988832 details
DDIT3_HUMANTRIB3_HUMANBioGRID, HPRD15775988 17872950 details
DDIT3_HUMANDNM3L_HUMANBioGRID24952347 details
DDIT3_HUMANGABR2_HUMANBioGRID16081421 details
DDIT3_HUMANRS3_HUMANBioGRID29371697 details
DDIT3_HUMANGIMA6_HUMANBioGRID32296183 details
DDIT3_HUMANHDAC1_HUMANBioGRID17872950 22242125 details
DDIT3_HUMANCSN7A_HUMANBioGRID23213463 details
DDIT3_HUMANCSN8_HUMANBioGRID23213463 details
DDIT3_HUMANCUL3_HUMANBioGRID23213463 details
DDIT3_HUMANCUL1_HUMANBioGRID23213463 details
DDIT3_HUMANCSN3_HUMANBioGRID23213463 details
DDIT3_HUMANKEAP1_HUMANBioGRID23213463 details
DDIT3_HUMANPPIB_HUMANBioGRID24270407 details
DDIT3_HUMANHDAC5_HUMANBioGRID17872950 details
DDIT3_HUMANHDAC6_HUMANBioGRID17872950 details
DDIT3_HUMANCBP_HUMANBioGRID20829347 details
DDIT3_HUMANGABR1_HUMANBioGRID16081421 details
DDIT3_HUMANBIP_HUMANBioGRID28947141 details
DDIT3_HUMANFUS_HUMANBioGRID30962207 details
DDIT3_HUMANSMCA4_HUMANBioGRID30962207 details
DDIT3_HUMANPICAL_HUMANHPRD1547942 details