Entity Details

Primary name MYH11_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35749
EntryNameMYH11_HUMAN
FullNameMyosin-11
TaxID9606
Evidenceevidence at protein level
Length1972
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesMYH11

GO terms

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GOName
GO:0003774 cytoskeletal motor activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0005859 muscle myosin complex
GO:0006936 muscle contraction
GO:0006939 smooth muscle contraction
GO:0008307 structural constituent of muscle
GO:0030241 skeletal muscle myosin thick filament assembly
GO:0032982 myosin filament
GO:0042470 melanosome
GO:0048251 elastic fiber assembly
GO:0051015 actin filament binding
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Melanosome

Domains

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DomainNameCategoryType
IPR000048 IQ motif, EF-hand binding siteSiteBinding site
IPR001609 Myosin head, motor domainDomainDomain
IPR002928 Myosin tailDomainDomain
IPR004009 Myosin, N-terminal, SH3-likeDomainDomain
IPR008989 Myosin S1 fragment, N-terminalFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036961 Kinesin motor domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
132900 OMIMAortic aneurysm, familial thoracic 4 (AAT4)A disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB04444 Tetrafluoroaluminate IonDrugbanksmall molecule