Entity Details

Primary name DHYS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49366
EntryNameDHYS_HUMAN
FullNameDeoxyhypusine synthase
TaxID9606
Evidenceevidence at protein level
Length369
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesDHPS

GO terms

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GOName
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006412 translation
GO:0008216 spermidine metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine
GO:0034038 deoxyhypusine synthase activity
GO:0042802 identical protein binding

Subcellular Location

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Domains

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DomainNameCategoryType
IPR002773 Deoxyhypusine synthaseFamilyFamily
IPR029035 DHS-like NAD/FAD-binding domain superfamilyFamilyHomologous superfamily
IPR036982 Deoxyhypusine synthase superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618480 OMIMNeurodevelopmental disorder with seizures and speech and walking impairment (NEDSSWI)An autosomal recessive disorder characterized by global developmental delay with intellectual disability and poor speech acquisition, and walking difficulties due to hypotonia, hypertonia, spasticity, or poor coordination. Additional features include seizures, mild dysmorphic features, and variable short stature. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB03639 1-Guanidinium-7-AminoheptaneDrugbanksmall molecule

Interactions

24 interactions

InteractorPartnerSourcesPublicationsLink
DHYS_HUMANNIF3L_HUMANBioGRID, HPRD, IntAct16189514 19060904 details
DHYS_HUMANNUD18_HUMANBioGRID, HPRD, IntAct16189514 19060904 details
DHYS_HUMANIF5A2_HUMANBioGRID, HPRD, IntAct16189514 25416956 32296183 details
DHYS_HUMANRL9_HUMANBioGRID, HPRD, IntAct16189514 25416956 28514442 32296183 details
DHYS_HUMANUBE2H_HUMANIntAct19549727 details
DHYS_HUMANMK03_HUMANBioGRID, IntAct23602568 24722188 25852190 26496610 31980649 32296183 details
DHYS_HUMANRB27B_HUMANBioGRID, IntAct25416956 32296183 details
DHYS_HUMANREL_HUMANBioGRID, IntAct25416956 32296183 details
DHYS_HUMANZN138_HUMANBioGRID, IntAct25416956 32296183 details
DHYS_HUMANIF5A1_HUMANBioGRID, HPRD, IntAct10229683 12562768 12788913 25416956 32296183 7929297 details
DHYS_HUMANVASH1_HUMANBioGRID, IntAct25416956 details
DHYS_HUMANNTAQ1_HUMANBioGRID, IntAct25416956 details
DHYS_HUMANPTPRH_HUMANBioGRID, IntAct25416956 details
DHYS_HUMANDHYS_HUMANBioGRID, HPRD, IntAct15100216 25416956 32296183 9493264 details
DHYS_HUMANPAX6_HUMANBioGRID, IntAct32296183 details
DHYS_HUMANRET1_HUMANBioGRID, IntAct32296183 details
DHYS_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
DHYS_HUMANBRCA1_HUMANBioGRID25184681 details
DHYS_HUMANMEOX2_HUMANBioGRID32296183 details
DHYS_HUMANEXOS4_HUMANBioGRID, IntAct27173435 unassigned1312 details
DHYS_HUMANEXOS7_HUMANBioGRID, IntAct27173435 unassigned1312 details
DHYS_HUMANEXOS2_HUMANBioGRID, IntAct27173435 unassigned1312 details
DHYS_HUMANSRRM2_HUMANBioGRID16159877 details
DHYS_HUMANTULP3_HUMANBioGRID33187986 details