Entity Details

Primary name MMP14_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP50281
EntryNameMMP14_HUMAN
FullNameMatrix metalloproteinase-14
TaxID9606
Evidenceevidence at protein level
Length582
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesMMP14

GO terms

Show/Hide Table
GOName
GO:0001501 skeletal system development
GO:0001525 angiogenesis
GO:0001541 ovarian follicle development
GO:0001666 response to hypoxia
GO:0001935 endothelial cell proliferation
GO:0001958 endochondral ossification
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005178 integrin binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005796 Golgi lumen
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006508 proteolysis
GO:0006979 response to oxidative stress
GO:0008270 zinc ion binding
GO:0008584 male gonad development
GO:0009612 response to mechanical stimulus
GO:0010831 positive regulation of myotube differentiation
GO:0010954 positive regulation of protein processing
GO:0014070 response to organic cyclic compound
GO:0016485 protein processing
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030307 positive regulation of cell growth
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0030574 collagen catabolic process
GO:0031012 extracellular matrix
GO:0031410 cytoplasmic vesicle
GO:0031638 zymogen activation
GO:0035987 endodermal cell differentiation
GO:0035988 chondrocyte proliferation
GO:0042470 melanosome
GO:0043615 astrocyte cell migration
GO:0043627 response to estrogen
GO:0044354 macropinosome
GO:0045111 intermediate filament cytoskeleton
GO:0045579 positive regulation of B cell differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048771 tissue remodeling
GO:0048870 cell motility
GO:0051895 negative regulation of focal adhesion assembly
GO:0060322 head development
GO:0070006 metalloaminopeptidase activity
GO:0097094 craniofacial suture morphogenesis
GO:1903076 regulation of protein localization to plasma membrane
GO:1905523 positive regulation of macrophage migration
GO:1990834 response to odorant

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Melanosome
Membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000585 Hemopexin-like domainDomainDomain
IPR001818 Peptidase M10, metallopeptidaseDomainDomain
IPR002477 Peptidoglycan binding-likeDomainDomain
IPR006026 Peptidase, metallopeptidaseDomainDomain
IPR018486 Hemopexin, conserved siteSiteConserved site
IPR018487 Hemopexin-like repeatsRepeatRepeat
IPR021158 Peptidase M10A, cysteine switch, zinc binding siteSiteBinding site
IPR021190 Peptidase M10AFamilyFamily
IPR021805 Peptidase M10A, matrix metallopeptidase, C-terminalDomainDomain
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR033739 Peptidase M10A, catalytic domainDomainDomain
IPR036365 PGBD-like superfamilyFamilyHomologous superfamily
IPR036366 PGBD superfamilyFamilyHomologous superfamily
IPR036375 Hemopexin-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
277950 OMIMWinchester syndrome (WNCHRS)A disease characterized by severe osteolysis in the hands and feet, generalized osteoporosis, bone thinning, and absence of subcutaneous nodules. Various additional features include coarse face, corneal opacities, gum hypertrophy, and EKG changes. The disease is caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB00786 MarimastatDrugbanksmall molecule

Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
MMP14_HUMANC1QBP_HUMANBioGRID, HPRD, MINT11773076 12220632 details
MMP14_HUMANMTND_HUMANHPRD, UniProt14718544 details
MMP14_HUMANFURIN_HUMANBioGRID, IntAct, MINT20608975 21152186 8804434 details
MMP14_HUMANRAD_HUMANBioGRID, IntAct21988832 details
MMP14_HUMANPLLP_HUMANBioGRID, IntAct21988832 details
MMP14_HUMANTIMP2_HUMANBioGRID, HPRD, MINT24112707 8804434 9422789 9724659 details
MMP14_HUMANLUM_HUMANBioGRID, HPRD, MINT15466200 25304424 details
MMP14_HUMANKASH5_HUMANBioGRID, IntAct25416956 details
MMP14_HUMANZUP1_HUMANBioGRID, IntAct32296183 details
MMP14_HUMANDHB13_HUMANBioGRID, IntAct32296183 details
MMP14_HUMANSTOM_HUMANBioGRID, IntAct32296183 details
MMP14_HUMANEBP_HUMANBioGRID, IntAct32296183 details
MMP14_HUMANJAM1_HUMANBioGRID, IntAct32296183 details
MMP14_HUMANFHL3_HUMANBioGRID, IntAct32296183 details
MMP14_HUMANMSMO1_HUMANBioGRID, IntAct32296183 details
MMP14_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
MMP14_HUMANELOV4_HUMANBioGRID, IntAct32296183 details
MMP14_HUMANTIMP1_HUMANBioGRID, IntAct26264872 32814053 8804434 details
MMP14_HUMANMMP3_HUMANBioGRID8804434 details
MMP14_HUMANTMM31_HUMANBioGRID32296183 details
MMP14_HUMANTGM2_HUMANBioGRID11278623 details
MMP14_HUMANBCAR1_HUMANBioGRID, HPRD, MINT18164686 details
MMP14_HUMANACTB_HUMANMINT18164686 details
MMP14_HUMANGORS2_HUMANMINT20608975 details
MMP14_HUMANGOGB1_HUMANMINT20608975 details
MMP14_HUMANTGON2_HUMANMINT20608975 details
MMP14_HUMANLIMK1_HUMANMolecular Connections21219645 details
MMP14_HUMANEGLN_HUMANIntAct22296769 details
MMP14_HUMANFGFR2_HUMANDIP20798051 details
MMP14_HUMANFGFR4_HUMANDIP20798051 details
MMP14_HUMANLRP1_HUMANBioGRID, HPRD14645246 details
MMP14_HUMANTICN3_HUMANBioGRID, HPRD11751414 details
MMP14_HUMANVPS35_HUMANBioGRID29891722 details
MMP14_HUMANCAV1_HUMANBioGRID, HPRD15466865 details
MMP14_HUMANCAH9_HUMANBioGRID28692057 details
MMP14_HUMANFBX6_HUMANBioGRID32409323 details
MMP14_HUMANTIMP3_HUMANHPRD8663332 details
MMP14_HUMANFA12_HUMANHPRD10930399 details
MMP14_HUMANMMP13_HUMANHPRD8663255 details
MMP14_HUMANKISS1_HUMANHPRD12879005 details
MMP14_HUMANCLD1_HUMANHPRD11382769 details
MMP14_HUMANTICN1_HUMANHPRD12810672 details
MMP14_HUMANITAV_HUMANHPRD11741954 details
MMP14_HUMANTIMP4_HUMANHPRD11178970 details
MMP14_HUMANSDC1_HUMANHPRD12464176 12904296 details
MMP14_HUMANMMP2_HUMANHPRD14583471 8663332 details
MMP14_HUMANPGCA_HUMANHPRD11854269 9688535 details
MMP14_HUMANCCL7_HUMANHPRD10947989 12149192 details