Entity Details

Primary name GPSM2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP81274
EntryNameGPSM2_HUMAN
FullNameG-protein-signaling modulator 2
TaxID9606
Evidenceevidence at protein level
Length684
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesGPSM2

GO terms

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GOName
GO:0000132 establishment of mitotic spindle orientation
GO:0000166 nucleotide binding
GO:0005092 GDP-dissociation inhibitor activity
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005938 cell cortex
GO:0007052 mitotic spindle organization
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008022 protein C-terminus binding
GO:0016328 lateral plasma membrane
GO:0019904 protein domain specific binding
GO:0031291 Ran protein signal transduction
GO:0032991 protein-containing complex
GO:0042802 identical protein binding
GO:0043621 protein self-association
GO:0051301 cell division
GO:0051661 maintenance of centrosome location
GO:0060236 regulation of mitotic spindle organization
GO:0070840 dynein complex binding
GO:0097431 mitotic spindle pole
GO:0097575 lateral cell cortex
GO:0099738 cell cortex region
GO:1904778 positive regulation of protein localization to cell cortex
GO:1905832 positive regulation of spindle assembly

Subcellular Location

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Subcellular Location
Cytoplasm
Lateral cell membrane

Domains

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DomainNameCategoryType
IPR003109 GoLoco motifSiteConserved site
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR019734 Tetratricopeptide repeatRepeatRepeat

Diseases

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Disease IDSourceNameDescription
604213 OMIMChudley-McCullough syndrome (CMCS)An autosomal recessive neurologic disorder characterized by early-onset sensorineural deafness and specific brain anomalies on MRI, including hypoplasia of the corpus callosum, enlarged cysterna magna with mild focal cerebellar dysplasia, and nodular heterotopia. Some patients have hydrocephalus. Psychomotor development is normal. The disease is caused by variants affecting the gene represented in this entry.