Entity Details

Primary name H33_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP84243
EntryNameH33_HUMAN
FullNameHistone H3.3
TaxID9606
Evidenceevidence at protein level
Length136
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesH3-3A
H3-3B

GO terms

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GOName
GO:0000183 rDNA heterochromatin assembly
GO:0000228 nuclear chromosome
GO:0000781 chromosome, telomeric region
GO:0000786 nucleosome
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001649 osteoblast differentiation
GO:0001740 Barr body
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006334 nucleosome assembly
GO:0006336 DNA replication-independent nucleosome assembly
GO:0006997 nucleus organization
GO:0007286 spermatid development
GO:0007338 single fertilization
GO:0007566 embryo implantation
GO:0007596 blood coagulation
GO:0008283 cell population proliferation
GO:0008584 male gonad development
GO:0030307 positive regulation of cell growth
GO:0031492 nucleosomal DNA binding
GO:0031508 pericentric heterochromatin assembly
GO:0031509 subtelomeric heterochromatin assembly
GO:0032200 telomere organization
GO:0032991 protein-containing complex
GO:0035264 multicellular organism growth
GO:0042692 muscle cell differentiation
GO:0045652 regulation of megakaryocyte differentiation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0046982 protein heterodimerization activity
GO:0048477 oogenesis
GO:0060765 regulation of androgen receptor signaling pathway
GO:0060964 regulation of gene silencing by miRNA
GO:0070062 extracellular exosome
GO:0090230 regulation of centromere complex assembly
GO:1900051 positive regulation of histone exchange
GO:1902340 negative regulation of chromosome condensation
GO:1990000 amyloid fibril formation

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR000164 Histone H3/CENP-AFamilyFamily
IPR007125 Histone H2A/H2B/H3DomainDomain
IPR009072 Histone-foldFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
137800 OMIMGlioma (GLM)Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. The gene represented in this entry is involved in disease pathogenesis. H3F3A mutations affecting residues involved in post-translational modifications of histone H3.3 are recurrent in malignant, aggressive gliomas including glioblastoma multiforme (GBM) and diffuse intrinsic pontine glioma (DIPG) (PubMed:22286061, PubMed:22286216). The mechanism through which mutations lead to tumorigenesis involves altered histones methylation, impaired regulation of Polycomb repressive complex 2 (PRC2) activity, and aberrant epigenetic regulation of gene expression (PubMed:23539269, PubMed:23539183, PubMed:23603901).

Interactions

118 interactions

InteractorPartnerSourcesPublicationsLink
H33_HUMANEHMT2_HUMANBioGRID, HPRD, IntAct16189514 17403666 details
H33_HUMANHIRA_HUMANBioGRID, HPRD, IntAct14718166 19410545 20211137 21047901 22195966 24209620 9731536 details
H33_HUMANCBX5_HUMANBioGRID, MINT17403666 19834512 24981860 details
H33_HUMANDNM3A_HUMANMINT19834512 details
H33_HUMANDNM3L_HUMANMINT19834512 details
H33_HUMANDAXX_HUMANBioGRID, DIP, IntAct, MINT20211137 20504901 20651253 21047901 23075851 23142979 23222847 23828041 24209620 24530302 24981860 25275136 27217568 27626385 32296183 details
H33_HUMANATRX_HUMANBioGRID, IntAct20110566 20211137 20504901 20651253 24530302 24981860 25538301 29937341 details
H33_HUMANPELP1_HUMANBioGRID, MINT20448663 27626385 details
H33_HUMANNOS3_HUMANBioGRID, IntAct21163940 details
H33_HUMANTAF3_HUMANMINT20953165 details
H33_HUMANBPTF_HUMANBioGRID, HPRD, MINT16728976 16728978 20953165 details
H33_HUMANPF21A_HUMANMINT20953165 details
H33_HUMANCBX3_HUMANBioGRID, IntAct17403666 22684280 27705803 details
H33_HUMANNASP_HUMANBioGRID, IntAct14718166 20504901 25416956 28514442 details
H33_HUMANCBX6_HUMANDIP18927235 details
H33_HUMANCBX2_HUMANDIP18927235 details
H33_HUMANCBX4_HUMANBioGRID, DIP18927235 26496610 details
H33_HUMANCBX7_HUMANDIP18927235 details
H33_HUMANCBX8_HUMANDIP18927235 details
H33_HUMANASF1B_HUMANBioGRID, DIP, HPRD14718166 15664198 20504901 20651253 23075851 24209620 26167883 details
H33_HUMANASF1A_HUMANBioGRID, DIP, HPRD14718166 15664198 18971269 20504901 23075851 23828041 24209620 27217568 details
H33_HUMANH33_HUMANDIP23075851 details
H33_HUMANHMGB2_HUMANBioGRID, UniProt29721183 details
H33_HUMANSSRP1_HUMANBioGRID17403666 21969370 details
H33_HUMANPARP1_HUMANBioGRID17403666 20504901 20525793 28190768 details
H33_HUMANPARP2_HUMANBioGRID20504901 28190768 details
H33_HUMANUBN1_HUMANBioGRID21047901 22195966 26159857 27217568 details
H33_HUMANKMT2A_HUMANBioGRID17166833 details
H33_HUMANSETD7_HUMANBioGRID17166833 details
H33_HUMANBRD1_HUMANBioGRID21880731 27142060 details
H33_HUMANZMY11_HUMANBioGRID24590075 details
H33_HUMANSUV91_HUMANBioGRID17172641 details
H33_HUMANESR1_HUMANBioGRID20348541 details
H33_HUMANAF9_HUMANBioGRID25417107 details
H33_HUMANHPF1_HUMANBioGRID28190768 details
H33_HUMANPIM1_HUMANBioGRID28620180 details
H33_HUMANRNF8_HUMANBioGRID28507061 details
H33_HUMANFBX7_HUMANBioGRID27503909 details
H33_HUMANPP1A_HUMANBioGRID23828041 details
H33_HUMANPP1B_HUMANBioGRID23828041 details
H33_HUMANPPM1D_HUMANBioGRID23828041 details
H33_HUMANNEDD4_HUMANBioGRID28300060 details
H33_HUMANEP300_HUMANBioGRID27626385 28300060 details
H33_HUMANSET_HUMANBioGRID27626385 details
H33_HUMANDCAF1_HUMANBioGRID27626385 details
H33_HUMANBRD4_HUMANBioGRID27626385 32416067 details
H33_HUMANBRD7_HUMANBioGRID27626385 details
H33_HUMANRBBP4_HUMANBioGRID, IntAct14718166 19410545 27705803 details
H33_HUMANING2_HUMANMINT20953165 details
H33_HUMANING4_HUMANMINT20953165 details
H33_HUMANNOC2L_HUMANUniProt16322561 details
H33_HUMANCBX1_HUMANBioGRID, IntAct17403666 27705803 details
H33_HUMANH4_HUMANBioGRID, DIP, IntAct14718166 21724829 23075851 23142979 24183680 24530302 26167883 27248496 details
H33_HUMANDC2I1_HUMANBioGRID, IntAct27173435 unassigned1312 details
H33_HUMANDC2I2_HUMANBioGRID, IntAct27173435 unassigned1312 details
H33_HUMANCAF1A_HUMANBioGRID, DIP23075851 details
H33_HUMANH32_HUMANBioGRID, IntAct24981860 30021884 details
H33_HUMANCA2D1_HUMANIntAct30021884 details
H33_HUMANREV3L_HUMANIntAct30021884 details
H33_HUMANH2A1B_HUMANBioGRID, IntAct27248496 30021884 details
H33_HUMANHMGB1_HUMANBioGRID, UniProt17403666 29721183 details
H33_HUMANCENPA_HUMANBioGRID15009096 24530302 details
H33_HUMANIPO4_HUMANBioGRID14718166 details
H33_HUMANHAT1_HUMANBioGRID14718166 20504901 24981860 details
H33_HUMANASH1L_HUMANBioGRID17403666 details
H33_HUMANCARM1_HUMANBioGRID, HPRD11751582 17403666 details
H33_HUMANEHMT1_HUMANBioGRID17403666 details
H33_HUMANKMT2C_HUMANBioGRID17403666 details
H33_HUMANKDM4C_HUMANBioGRID17403666 details
H33_HUMANHDAC5_HUMANBioGRID17403666 details
H33_HUMANHDAC9_HUMANBioGRID17403666 details
H33_HUMANNUCL_HUMANBioGRID17403666 details
H33_HUMANSP16H_HUMANBioGRID, HPRD15616580 17403666 details
H33_HUMANCHD4_HUMANBioGRID17403666 details
H33_HUMANSF3B1_HUMANBioGRID17403666 details
H33_HUMANTR150_HUMANBioGRID17403666 details
H33_HUMANSP130_HUMANBioGRID17403666 details
H33_HUMANTIF1B_HUMANBioGRID17403666 details
H33_HUMANSF3B2_HUMANBioGRID17403666 details
H33_HUMANHNRPK_HUMANBioGRID17403666 details
H33_HUMANCCD71_HUMANBioGRID17403666 details
H33_HUMANRNF41_HUMANBioGRID17403666 details
H33_HUMANFBRL_HUMANBioGRID17403666 details
H33_HUMANDHR12_HUMANBioGRID17403666 details
H33_HUMANH2B2E_HUMANBioGRID17403666 details
H33_HUMANH15_HUMANBioGRID17403666 details
H33_HUMANKAT2B_HUMANBioGRID, HPRD15616580 20651253 28300060 details
H33_HUMANPRKDC_HUMANBioGRID20504901 details
H33_HUMANTOP2A_HUMANBioGRID20504901 details
H33_HUMANIMA3_HUMANBioGRID20504901 details
H33_HUMANXRCC5_HUMANBioGRID20504901 details
H33_HUMANXRCC6_HUMANBioGRID20504901 details
H33_HUMANTOP1_HUMANBioGRID20504901 details
H33_HUMANCABIN_HUMANBioGRID21047901 22195966 27217568 details
H33_HUMANKDM4A_HUMANBioGRID21931800 details
H33_HUMANITA4_HUMANBioGRID22623428 details
H33_HUMANH2AY_HUMANBioGRID23319141 24981860 details
H33_HUMANPML_HUMANBioGRID23222847 details
H33_HUMANAP2A_HUMANBioGRID23828041 details
H33_HUMANKAT2A_HUMANBioGRID28300060 details
H33_HUMANFGF2_HUMANBioGRID22539306 details
H33_HUMANFGFR1_HUMANBioGRID22539306 details
H33_HUMANTY3H_HUMANBioGRID22539306 details
H33_HUMANDPF3_HUMANBioGRID27402533 details
H33_HUMANCDN1A_HUMANBioGRID27626385 details
H33_HUMANBBC3B_HUMANBioGRID27626385 details
H33_HUMANBBC3_HUMANBioGRID27626385 details
H33_HUMANACTG_HUMANBioGRID23160995 details
H33_HUMANH2AX_HUMANBioGRID24981860 29937341 details
H33_HUMANSSXT_HUMANHPRD11591653 details
H33_HUMANTLE2_HUMANHPRD9334241 details
H33_HUMANMK09_HUMANHPRD11278789 details
H33_HUMANPAR10_HUMANHPRD15674325 details
H33_HUMANKAT5_HUMANHPRD10096020 details
H33_HUMANCBP_HUMANHPRD15616580 details
H33_HUMANSMCA5_HUMANHPRD15616580 16728976 details
H33_HUMANCHD1_HUMANHPRD16728976 details
H33_HUMANSMCA1_HUMANHPRD16728976 details