Entity Details

Primary name XPC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ01831
EntryNameXPC_HUMAN
FullNameDNA repair protein complementing XP-C cells
TaxID9606
Evidenceevidence at protein level
Length940
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesXPC

GO terms

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GOName
GO:0000109 nucleotide-excision repair complex
GO:0000111 nucleotide-excision repair factor 2 complex
GO:0000404 heteroduplex DNA loop binding
GO:0000405 bubble DNA binding
GO:0000715 nucleotide-excision repair, DNA damage recognition
GO:0000717 nucleotide-excision repair, DNA duplex unwinding
GO:0000720 pyrimidine dimer repair by nucleotide-excision repair
GO:0003684 damaged DNA binding
GO:0003697 single-stranded DNA binding
GO:0003713 transcription coactivator activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006298 mismatch repair
GO:0010224 response to UV-B
GO:0010996 response to auditory stimulus
GO:0031573 mitotic intra-S DNA damage checkpoint signaling
GO:0042493 response to drug
GO:0043231 intracellular membrane-bounded organelle
GO:0044877 protein-containing complex binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0070911 global genome nucleotide-excision repair
GO:0070914 UV-damage excision repair
GO:0071942 XPC complex
GO:0090734 site of DNA damage
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1990731 UV-damage excision repair, DNA incision

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR004583 DNA repair protein Rad4FamilyFamily
IPR018026 DNA repair protein Rad4, subgroupFamilyFamily
IPR018325 Rad4/PNGase transglutaminase-like foldDomainDomain
IPR018326 Rad4 beta-hairpin domain 1DomainDomain
IPR018327 Rad4 beta-hairpin domain 2DomainDomain
IPR018328 Rad4 beta-hairpin domain 3DomainDomain
IPR036985 Transglutaminase-like superfamilyFamilyHomologous superfamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily
IPR042488 Rad4, beta-hairpin domain 3 superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
278720 OMIMXeroderma pigmentosum complementation group C (XP-C)An autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. The skin develops marked freckling and other pigmentation abnormalities. The disease is caused by variants affecting the gene represented in this entry.

Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
XPC_HUMANLSM3_HUMANBioGRID, HPRD, IntAct15231747 details
XPC_HUMANZ512B_HUMANBioGRID, MINT15231748 details
XPC_HUMANSMAD1_HUMANBioGRID, HPRD, MINT15231748 details
XPC_HUMANOGG1_HUMANMINT16957781 details
XPC_HUMANRD23B_HUMANBioGRID, HPRD, IntAct, UniProt10488153 10873465 11259578 11279143 17154534 21962512 22431748 24258024 24981860 28473198 28514442 28760956 9164480 9372923 9372924 9734359 details
XPC_HUMANTF2H1_HUMANBioGRID, DIP, HPRD, UniProt10734143 11259578 26278177 details
XPC_HUMANERCC3_HUMANBioGRID, DIP, HPRD, UniProt10734143 26278177 details
XPC_HUMANCETN2_HUMANBioGRID, HPRD, IntAct11279143 17154534 21962512 22939629 26638075 27880911 28514442 28760956 details
XPC_HUMANDDB2_HUMANBioGRID, DIP, HPRD15882621 22039351 23319653 27203177 28760956 29604309 details
XPC_HUMANRD23A_HUMANBioGRID, HPRD24258024 9164480 9372924 details
XPC_HUMANXPA_HUMANBioGRID12486030 17154534 details
XPC_HUMANHMGB1_HUMANBioGRID19446504 details
XPC_HUMANRFA1_HUMANBioGRID15914671 24981860 details
XPC_HUMANMDM2_HUMANBioGRID24258024 details
XPC_HUMANPSMD4_HUMANBioGRID25118285 details
XPC_HUMANUBP7_HUMANBioGRID25118285 31775559 details
XPC_HUMANTDG_HUMANBioGRID, HPRD12505994 details
XPC_HUMANXPF_HUMANMINT19279666 details
XPC_HUMANCAF1A_HUMANBioGRID, MINT19059499 19279666 details
XPC_HUMANPCNA_HUMANMINT19279666 details
XPC_HUMANH2AX_HUMANBioGRID, IntAct19805520 28242625 28514442 details
XPC_HUMANPARP1_HUMANBioGRID, IntAct28514442 28760956 34079125 details
XPC_HUMANCETN3_HUMANBioGRID, IntAct28514442 30251372 details
XPC_HUMANPRS8_HUMANUniProt17693435 details
XPC_HUMANSNF5_HUMANBioGRID19805520 details
XPC_HUMANATR_HUMANBioGRID19805520 23422745 details
XPC_HUMANATM_HUMANBioGRID19805520 23422745 details
XPC_HUMANBAF_HUMANBioGRID19759913 details
XPC_HUMANDDB1_HUMANBioGRID15882621 details
XPC_HUMANUBE4B_HUMANBioGRID19889839 details
XPC_HUMANPO5F1_HUMANBioGRID21962512 26687479 details
XPC_HUMANRN111_HUMANBioGRID23751493 details
XPC_HUMANP53_HUMANBioGRID24258024 details
XPC_HUMANMTF1_HUMANBioGRID28416769 details
XPC_HUMANUBP22_HUMANBioGRID31740444 details
XPC_HUMANXPC_HUMANHPRD11279143 details