Entity Details

Primary name ROR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ01973
EntryNameROR1_HUMAN
FullNameInactive tyrosine-protein kinase transmembrane receptor ROR1
TaxID9606
Evidenceevidence at protein level
Length937
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesROR1

GO terms

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GOName
GO:0001725 stress fiber
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007605 sensory perception of sound
GO:0009986 cell surface
GO:0010976 positive regulation of neuron projection development
GO:0014002 astrocyte development
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0017147 Wnt-protein binding
GO:0033674 positive regulation of kinase activity
GO:0042813 Wnt-activated receptor activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0043679 axon terminus
GO:0048839 inner ear development
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway

Subcellular Location

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Subcellular Location
Cell projection
Membrane

Domains

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DomainNameCategoryType
IPR000001 KringleDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR016247 Tyrosine-protein kinase, receptor RORFamilyFamily
IPR018056 Kringle, conserved siteSiteConserved site
IPR020067 Frizzled domainDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR036790 Frizzled cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR038178 Kringle superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617654 OMIMDeafness, autosomal recessive, 108 (DFNB108)A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. The disease is caused by variants affecting the gene represented in this entry.