Entity Details

Primary name CX3CR1
Entity type gene
Source Source Link

Details

PrimaryID1524
RefseqGeneNG_016362
SymbolCX3CR1
NameC-X3-C motif chemokine receptor 1
Chromosome3
Location3p22.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-06
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsCX3C1_HUMAN

GO terms

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GOName
GO:0002052 positive regulation of neuroblast proliferation
GO:0002931 response to ischemia
GO:0004930 G protein-coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0006968 cellular defense response
GO:0007155 cell adhesion
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0007613 memory
GO:0008528 G protein-coupled peptide receptor activity
GO:0009611 response to wounding
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016032 viral process
GO:0016493 C-C chemokine receptor activity
GO:0016495 C-X3-C chemokine receptor activity
GO:0019722 calcium-mediated signaling
GO:0019957 C-C chemokine binding
GO:0019960 C-X3-C chemokine binding
GO:0021626 central nervous system maturation
GO:0030336 negative regulation of cell migration
GO:0032680 regulation of tumor necrosis factor production
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032809 neuronal cell body membrane
GO:0035176 social behavior
GO:0035425 autocrine signaling
GO:0043005 neuron projection
GO:0045087 innate immune response
GO:0045428 regulation of nitric oxide biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0048167 regulation of synaptic plasticity
GO:0048471 perinuclear region of cytoplasm
GO:0050767 regulation of neurogenesis
GO:0050769 positive regulation of neurogenesis
GO:0050804 modulation of chemical synaptic transmission
GO:0050901 leukocyte tethering or rolling
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0060074 synapse maturation
GO:0060326 cell chemotaxis
GO:0071222 cellular response to lipopolysaccharide
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0097447 dendritic tree
GO:0098883 synapse pruning
GO:0110091 negative regulation of hippocampal neuron apoptotic process
GO:0150090 multiple spine synapse organization, single dendrite
GO:1900272 negative regulation of long-term synaptic potentiation
GO:1903721 positive regulation of I-kappaB phosphorylation
GO:1904139 regulation of microglial cell migration
GO:1904141 positive regulation of microglial cell migration
GO:2001234 negative regulation of apoptotic signaling pathway

Diseases

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Disease IDSourceNameDescription
613784 OMIMMacular degeneration, age-related, 12 (ARMD12)A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
CX3CR1CCDC167BioGRID, IntAct32296183 details
CX3CR1CX3CL1BioGRID, HPRD, IntAct23125415 9390561 9931005 details
CX3CR1HIF1ABioGRID22952674 details
CX3CR1ITGA4IntAct23125415 details
CX3CR1ITGB3IntAct23125415 details