Entity Details

Primary name TRIPC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14669
EntryNameTRIPC_HUMAN
FullNameE3 ubiquitin-protein ligase TRIP12
TaxID9606
Evidenceevidence at protein level
Length1992
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesTRIP12

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006281 DNA repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0016607 nuclear speck
GO:0045995 regulation of embryonic development
GO:0046966 thyroid hormone receptor binding
GO:0061630 ubiquitin protein ligase activity
GO:1901315 negative regulation of histone H2A K63-linked ubiquitination
GO:2000779 regulation of double-strand break repair
GO:2000780 negative regulation of double-strand break repair

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000569 HECT domainDomainDomain
IPR004170 WWE domainDomainDomain
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily
IPR037197 WWE domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617752 OMIMClark-Baraitser syndrome (CLABARS)An autosomal dominant disease characterized by intellectual disability, delayed psychomotor development, behavioral abnormalities, variable dysmorphic facial features, tall stature, obesity, and macrocephaly. The disease is caused by variants affecting the gene represented in this entry.

Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
TRIPC_HUMANCSTN1_HUMANBioGRID, HPRD, IntAct12421765 details
TRIPC_HUMANCRNS1_HUMANBioGRID, HPRD, IntAct12421765 details
TRIPC_HUMANCELR3_HUMANHPRD, IntAct12421765 unassigned5 details
TRIPC_HUMANMCAF1_HUMANHPRD, MINT15231748 details
TRIPC_HUMANSMAD9_HUMANBioGRID, HPRD, MINT15231748 details
TRIPC_HUMANMTR1A_HUMANBioGRID, IntAct26514267 details
TRIPC_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
TRIPC_HUMANMYC_HUMANBioGRID, DIP20208519 29467282 details
TRIPC_HUMANARF_HUMANBioGRID, DIP20208519 22561347 23034180 24769896 27323397 details
TRIPC_HUMANULA1_HUMANBioGRID18627766 details
TRIPC_HUMANCDN2A_HUMANBioGRID20208519 22561347 23034180 24769896 27323397 details
TRIPC_HUMANNMI_HUMANBioGRID23034180 details
TRIPC_HUMANUB2D1_HUMANBioGRID18627766 19028681 23663701 9575161 details
TRIPC_HUMANUB2L3_HUMANBioGRID29643511 32755579 9575161 details
TRIPC_HUMANSOX6_HUMANBioGRID23663701 details
TRIPC_HUMANUBC_HUMANBioGRID19028681 27182664 29499138 details
TRIPC_HUMANUBE4B_HUMANBioGRID18627766 details
TRIPC_HUMANPTF1A_HUMANBioGRID25355311 details
TRIPC_HUMANSRPK2_HUMANBioGRID26167880 details
TRIPC_HUMANERG_HUMANBioGRID27626314 details
TRIPC_HUMANUB2D2_HUMANBioGRID29643511 details
TRIPC_HUMANPARP1_HUMANBioGRID32755579 34079125 details
TRIPC_HUMANOGT1_HUMANBioGRID32994395 details
TRIPC_HUMANTHB_HUMANHPRD7776974 details
TRIPC_HUMANUBP7_HUMANBioGRID, IntAct19615732 27800609 30367141 30804394 details
TRIPC_HUMANPIHD1_HUMANIntAct24656813 details
TRIPC_HUMANNPM_HUMANDIP20208519 details
TRIPC_HUMANDISC1_HUMANIntAct31413325 details
TRIPC_HUMANSMCE1_HUMANBioGRID20829358 details
TRIPC_HUMANTRADD_HUMANBioGRID22561347 details
TRIPC_HUMANGNL3_HUMANBioGRID24769896 details
TRIPC_HUMANCPSF1_HUMANBioGRID29395067 details
TRIPC_HUMANSHLD2_HUMANBioGRID30154076 details
TRIPC_HUMANECT2_HUMANBioGRID32929379 details