Entity Details

Primary name STAT4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14765
EntryNameSTAT4_HUMAN
FullNameSignal transducer and activator of transcription 4
TaxID9606
Evidenceevidence at protein level
Length748
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesSTAT4

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006952 defense response
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0019221 cytokine-mediated signaling pathway
GO:0035722 interleukin-12-mediated signaling pathway
GO:0038114 interleukin-21-mediated signaling pathway
GO:0038155 interleukin-23-mediated signaling pathway
GO:0042127 regulation of cell population proliferation
GO:0042802 identical protein binding
GO:0043434 response to peptide hormone
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0070757 interleukin-35-mediated signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001217 Transcription factor STATFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR012345 STAT transcription factor, DNA-binding, N-terminalFamilyHomologous superfamily
IPR013799 STAT transcription factor, protein interactionDomainDomain
IPR013800 STAT transcription factor, all-alpha domainDomainDomain
IPR013801 STAT transcription factor, DNA-bindingDomainDomain
IPR015988 STAT transcription factor, coiled coilFamilyHomologous superfamily
IPR029839 Signal transducer and activator of transcription 4FamilyFamily
IPR035856 STAT4, SH2 domainDomainDomain
IPR036535 STAT transcription factor, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
180300 OMIMRheumatoid arthritis (RA)An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Disease susceptibility is associated with variants affecting the gene represented in this entry.
612253 OMIMSystemic lupus erythematosus 11 (SLEB11)A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Disease susceptibility is associated with variants affecting the gene represented in this entry.