Entity Details

Primary name CRYM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14894
EntryNameCRYM_HUMAN
FullNameKetimine reductase mu-crystallin
TaxID9606
Evidenceevidence at protein level
Length314
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesCRYM

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003714 transcription corepressor activity
GO:0005737 cytoplasm
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0006554 lysine catabolic process
GO:0007605 sensory perception of sound
GO:0042403 thyroid hormone metabolic process
GO:0042562 hormone binding
GO:0042803 protein homodimerization activity
GO:0047127 thiomorpholine-carboxylate dehydrogenase activity
GO:0050661 NADP binding
GO:0070062 extracellular exosome
GO:0070324 thyroid hormone binding
GO:0070327 thyroid hormone transport

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR003462 Ornithine cyclodeaminase/mu-crystallinFamilyFamily
IPR023401 Ornithine cyclodeaminase, N-terminalFamilyHomologous superfamily
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616357 OMIMDeafness, autosomal dominant, 40 (DFNA40)A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB05235 NRP409Drugbanksmall molecule

Interactions

6 interactions