Entity Details

Primary name PDCD1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15116
EntryNamePDCD1_HUMAN
FullNameProgrammed cell death protein 1
TaxID9606
Evidenceevidence at protein level
Length288
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesPDCD1

GO terms

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GOName
GO:0002250 adaptive immune response
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0006959 humoral immune response
GO:0007275 multicellular organism development
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0031295 T cell costimulation
GO:0050776 regulation of immune response
GO:0050777 negative regulation of immune response
GO:0070234 positive regulation of T cell apoptotic process

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR042379 Programmed cell death protein 1FamilyFamily

Diseases

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Disease IDSourceNameDescription
605218 OMIMSystemic lupus erythematosus 2 (SLEB2)A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB05916 CT-011Drugbankbiotech
DB09035 NivolumabDrugbankbiotech
DB09037 PembrolizumabDrugbankbiotech
DB14707 CemiplimabDrugbankbiotech
DB14776 CamrelizumabDrugbankbiotech
DB14892 SpartalizumabDrugbankbiotech
DB14922 TislelizumabDrugbankbiotech
DB15043 ToripalimabDrugbankbiotech
DB15627 DostarlimabDrugbankbiotech
DB15765 SintilimabDrugbankbiotech
DB15766 RetifanlimabDrugbankbiotech
DB15767 AMP-224Drugbankbiotech
DB15768 MEDI0680Drugbankbiotech