Entity Details

Primary name IFNG
Entity type gene
Source Source Link

Details

PrimaryID3458
RefseqGeneNG_015840
SymbolIFNG
Nameinterferon gamma
Chromosome12
Location12q15
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-27
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsIFNG_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001774 microglial cell activation
GO:0001819 positive regulation of cytokine production
GO:0001934 positive regulation of protein phosphorylation
GO:0002250 adaptive immune response
GO:0002281 macrophage activation involved in immune response
GO:0005125 cytokine activity
GO:0005133 interferon-gamma receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006915 apoptotic process
GO:0006959 humoral immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0008284 positive regulation of cell population proliferation
GO:0009615 response to virus
GO:0010508 positive regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0010835 regulation of protein ADP-ribosylation
GO:0030225 macrophage differentiation
GO:0030857 negative regulation of epithelial cell differentiation
GO:0031334 positive regulation of protein-containing complex assembly
GO:0032700 negative regulation of interleukin-17 production
GO:0032722 positive regulation of chemokine production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0032747 positive regulation of interleukin-23 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032834 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0034393 positive regulation of smooth muscle cell apoptotic process
GO:0035722 interleukin-12-mediated signaling pathway
GO:0040008 regulation of growth
GO:0042307 positive regulation of protein import into nucleus
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045589 regulation of regulatory T cell differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045821 positive regulation of glycolytic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048143 astrocyte activation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0050766 positive regulation of phagocytosis
GO:0050769 positive regulation of neurogenesis
GO:0050796 regulation of insulin secretion
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051173 positive regulation of nitrogen compound metabolic process
GO:0051607 defense response to virus
GO:0051712 positive regulation of killing of cells of other organism
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060550 positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
GO:0060552 positive regulation of fructose 1,6-bisphosphate metabolic process
GO:0060557 positive regulation of vitamin D biosynthetic process
GO:0060559 positive regulation of calcidiol 1-monooxygenase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090312 positive regulation of protein deacetylation
GO:0097191 extrinsic apoptotic signaling pathway
GO:0150076 neuroinflammatory response
GO:1900222 negative regulation of amyloid-beta clearance
GO:1901216 positive regulation of neuron death
GO:1901857 positive regulation of cellular respiration
GO:1902004 positive regulation of amyloid-beta formation
GO:1902948 negative regulation of tau-protein kinase activity
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903543 positive regulation of exosomal secretion
GO:1904440 positive regulation of iron ion import across plasma membrane
GO:1904783 positive regulation of NMDA glutamate receptor activity
GO:1904798 positive regulation of core promoter binding
GO:2000273 positive regulation of signaling receptor activity
GO:2000309 positive regulation of tumor necrosis factor (ligand) superfamily member 11 production

Diseases

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Disease IDSourceNameDescription
618963 OMIMImmunodeficiency 69 (IMD69)A form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. IMD69 is an autosomal recessive disorder manifesting with fever, hepatosplenomegaly, leukocytosis, and thrombocytosis during the acute infection. The disease is caused by variants affecting the gene represented in this entry.
609135 OMIMAplastic anemia (AA)A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia. Disease susceptibility may be associated with variants affecting the gene represented in this entry.