Entity Details

Primary name STK11_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15831
EntryNameSTK11_HUMAN
FullNameSerine/threonine-protein kinase STK11
TaxID9606
Evidenceevidence at protein level
Length433
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesSTK11

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001558 regulation of cell growth
GO:0001894 tissue homeostasis
GO:0001944 vasculature development
GO:0002039 p53 binding
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006470 protein dephosphorylation
GO:0006914 autophagy
GO:0006974 cellular response to DNA damage stimulus
GO:0007283 spermatogenesis
GO:0007409 axonogenesis
GO:0008285 negative regulation of cell population proliferation
GO:0010212 response to ionizing radiation
GO:0010508 positive regulation of autophagy
GO:0016020 membrane
GO:0030010 establishment of cell polarity
GO:0030275 LRR domain binding
GO:0030295 protein kinase activator activity
GO:0030308 negative regulation of cell growth
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032147 activation of protein kinase activity
GO:0042593 glucose homeostasis
GO:0043276 anoikis
GO:0045059 positive thymic T cell selection
GO:0046777 protein autophosphorylation
GO:0048814 regulation of dendrite morphogenesis
GO:0050772 positive regulation of axonogenesis
GO:0050852 T cell receptor signaling pathway
GO:0051645 Golgi localization
GO:0051896 regulation of protein kinase B signaling
GO:0060070 canonical Wnt signaling pathway
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0070062 extracellular exosome
GO:0071493 cellular response to UV-B
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097484 dendrite extension
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1900182 positive regulation of protein localization to nucleus
GO:1901610 positive regulation of vesicle transport along microtubule
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1904262 negative regulation of TORC1 signaling

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR039154 Serine/Threonine kinase LKB1, catalytic domainDomainDomain

Diseases

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Disease IDSourceNameDescription
175200 OMIMPeutz-Jeghers syndrome (PJS)An autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer. The disease is caused by variants affecting the gene represented in this entry.
273300 OMIMTesticular germ cell tumor (TGCT)A common malignancy in males representing 95% of all testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma. The gene represented in this entry may be involved in disease pathogenesis.

Interactions

166 interactions

InteractorPartnerSourcesPublicationsLink
STK11_HUMANSMCA4_HUMANBioGRID, IntAct11445556 14676191 28205554 details
STK11_HUMANSTRAB_HUMANBioGRID, HPRD, IntAct14676191 20562859 28514442 details
STK11_HUMANSTRAA_HUMANBioGRID, DIP, HPRD, IntAct, MINT12805220 14676191 15561763 15733851 19513107 20562859 21860411 25241761 25852190 26479318 28514442 31554794 details
STK11_HUMANMARK4_HUMANBioGRID, HPRD, IntAct14676191 details
STK11_HUMANSNRK_HUMANBioGRID, HPRD, MINT15733851 details
STK11_HUMANPHOCN_HUMANHPRD, IntAct16169070 details
STK11_HUMANWDR6_HUMANBioGRID, IntAct17216128 details
STK11_HUMANTNIP2_HUMANBioGRID, HPRD, IntAct, UniProt12595760 12753905 27609421 details
STK11_HUMANSTK11_HUMANBioGRID, HPRD, IntAct11668633 20562859 28205554 details
STK11_HUMANTBC23_HUMANBioGRID, MINT21516116 details
STK11_HUMANP53_HUMANBioGRID, HPRD, I2D11430832 21317932 28205554 details
STK11_HUMAN1433G_HUMANBioGRID, MINT22575644 28205554 details
STK11_HUMAN1433F_HUMANMINT22575644 details
STK11_HUMAN1433Z_HUMANMINT22575644 details
STK11_HUMANAAPK1_HUMANBioGRID, MINT16912160 22575644 31217475 31995728 details
STK11_HUMANAKT1_HUMANBioGRID, MINT24412244 28205554 details
STK11_HUMANALDOB_HUMANBioGRID, MINT24412244 details
STK11_HUMANAN32B_HUMANBioGRID, MINT24412244 details
STK11_HUMANTRMO_HUMANBioGRID, MINT24412244 details
STK11_HUMANCC14B_HUMANBioGRID, MINT24412244 details
STK11_HUMANCYLC2_HUMANBioGRID, MINT24412244 details
STK11_HUMANF16P1_HUMANBioGRID, MINT24412244 details
STK11_HUMANF16P2_HUMANBioGRID, MINT24412244 details
STK11_HUMANRASH_HUMANBioGRID, MINT24412244 details
STK11_HUMANIBP3_HUMANBioGRID, MINT24412244 details
STK11_HUMANCC180_HUMANBioGRID, MINT24412244 details
STK11_HUMANLEF1_HUMANBioGRID, MINT24412244 details
STK11_HUMANMP2K1_HUMANBioGRID, MINT24412244 details
STK11_HUMANMAPK3_HUMANMINT24412244 details
STK11_HUMANSIAS_HUMANBioGRID, MINT24412244 details
STK11_HUMANPP2AB_HUMANBioGRID, MINT24412244 details
STK11_HUMANRASA1_HUMANBioGRID, MINT24412244 details
STK11_HUMANSTX17_HUMANBioGRID, MINT24412244 details
STK11_HUMANTDRD7_HUMANBioGRID, MINT24412244 details
STK11_HUMANXPA_HUMANBioGRID, MINT24412244 details
STK11_HUMANZN189_HUMANBioGRID, MINT24412244 details
STK11_HUMANZN510_HUMANBioGRID, MINT24412244 details
STK11_HUMANCALM2_HUMANBioGRID, MINT25640309 details
STK11_HUMANPAQR1_HUMANBioGRID, MINT25640309 details
STK11_HUMANARGI2_HUMANBioGRID, MINT25640309 details
STK11_HUMANCATB_HUMANBioGRID, MINT25640309 details
STK11_HUMANCOF2_HUMANBioGRID, MINT25640309 details
STK11_HUMANCRY2_HUMANBioGRID, MINT25640309 details
STK11_HUMANERLEC_HUMANBioGRID, MINT25640309 details
STK11_HUMAND2HDH_HUMANBioGRID, MINT25640309 details
STK11_HUMANEF1A2_HUMANBioGRID, MINT25640309 details
STK11_HUMANNU2M_HUMANBioGRID, MINT25640309 details
STK11_HUMANGNPI1_HUMANBioGRID, MINT25640309 details
STK11_HUMANLFG2_HUMANBioGRID, MINT25640309 details
STK11_HUMANPHF23_HUMANBioGRID, MINT25640309 details
STK11_HUMANMOC2A_HUMANBioGRID, MINT25640309 details
STK11_HUMANPLPP_HUMANBioGRID, MINT25640309 details
STK11_HUMANPLD3_HUMANBioGRID, MINT25640309 details
STK11_HUMANSEPT9_HUMANBioGRID, MINT25640309 details
STK11_HUMANSTK24_HUMANBioGRID, MINT25640309 details
STK11_HUMANTHOP1_HUMANBioGRID, MINT25640309 details
STK11_HUMANTS101_HUMANBioGRID, MINT25640309 details
STK11_HUMANTBA1A_HUMANBioGRID, MINT25640309 details
STK11_HUMANTBB4A_HUMANBioGRID, MINT25640309 details
STK11_HUMANVPS72_HUMANBioGRID, MINT25640309 details
STK11_HUMANBCAS3_HUMANBioGRID, MINT25640309 details
STK11_HUMANCP17A_HUMANBioGRID, MINT25640309 details
STK11_HUMANKLK7_HUMANBioGRID, MINT25640309 details
STK11_HUMANLYPD3_HUMANBioGRID, MINT25640309 details
STK11_HUMANARY2_HUMANBioGRID, MINT25640309 details
STK11_HUMANRHBT2_HUMANBioGRID, MINT25640309 details
STK11_HUMANS10AE_HUMANBioGRID, MINT25640309 details
STK11_HUMANSPB5_HUMANBioGRID, MINT25640309 details
STK11_HUMANST14_HUMANBioGRID, MINT25640309 details
STK11_HUMANTHRSP_HUMANBioGRID, MINT25640309 details
STK11_HUMANTRI25_HUMANBioGRID, MINT25640309 details
STK11_HUMANTSP50_HUMANBioGRID, MINT25640309 details
STK11_HUMANNR4A1_HUMANDIP25822914 details
STK11_HUMANS11IP_HUMANBioGRID, HPRD11741830 details
STK11_HUMANMARK2_HUMANBioGRID, HPRD14976552 16396636 details
STK11_HUMANSIK1_HUMANBioGRID16396636 details
STK11_HUMANUB2D2_HUMANBioGRID21860411 details
STK11_HUMANA4_HUMANBioGRID21832049 details
STK11_HUMANETV4_HUMANBioGRID16912160 21150337 details
STK11_HUMANSIR1_HUMANBioGRID18687677 27259994 details
STK11_HUMANSPDEF_HUMANBioGRID16912160 details
STK11_HUMANMARE1_HUMANBioGRID24552808 details
STK11_HUMANCALM1_HUMANBioGRID25640309 details
STK11_HUMANCALM3_HUMANBioGRID25640309 details
STK11_HUMANMOC2B_HUMANBioGRID25640309 details
STK11_HUMANHERC2_HUMANBioGRID27259994 details
STK11_HUMANPTEN_HUMANBioGRID, HPRD15987703 details
STK11_HUMANARAF_HUMANBioGRID28205554 details
STK11_HUMANARNT_HUMANBioGRID28205554 details
STK11_HUMANCBLC_HUMANBioGRID28205554 details
STK11_HUMANCCND2_HUMANBioGRID28205554 details
STK11_HUMANCDK4_HUMANBioGRID28205554 details
STK11_HUMANCDK6_HUMANBioGRID28205554 details
STK11_HUMANCDN2A_HUMANBioGRID28205554 details
STK11_HUMANARF_HUMANBioGRID28205554 details
STK11_HUMANERBB2_HUMANBioGRID28205554 details
STK11_HUMANFZR1_HUMANBioGRID28205554 details
STK11_HUMANGLIS2_HUMANBioGRID28205554 details
STK11_HUMANHGF_HUMANBioGRID28205554 details
STK11_HUMANKAT2A_HUMANBioGRID28205554 details
STK11_HUMANERD22_HUMANBioGRID28205554 details
STK11_HUMANMP2K5_HUMANBioGRID28205554 details
STK11_HUMANMET_HUMANBioGRID28205554 details
STK11_HUMANMYC_HUMANBioGRID28205554 details
STK11_HUMANMERL_HUMANBioGRID28205554 details
STK11_HUMANRASF1_HUMANBioGRID28205554 details
STK11_HUMANCCNE1_HUMANBioGRID28205554 details
STK11_HUMANCDN2B_HUMANBioGRID28205554 details
STK11_HUMANFGFR4_HUMANBioGRID28205554 details
STK11_HUMANLATS2_HUMANBioGRID28205554 details
STK11_HUMANMP2K3_HUMANBioGRID28205554 28628118 details
STK11_HUMANABCB5_HUMANBioGRID28205554 details
STK11_HUMANAURKA_HUMANBioGRID28205554 details
STK11_HUMANBECN1_HUMANBioGRID28205554 details
STK11_HUMANBRAF_HUMANBioGRID28205554 details
STK11_HUMANCD44_HUMANBioGRID28205554 details
STK11_HUMANCDN2C_HUMANBioGRID28205554 details
STK11_HUMANDACH1_HUMANBioGRID28205554 details
STK11_HUMANGRM1_HUMANBioGRID28205554 details
STK11_HUMANHIF1A_HUMANBioGRID28205554 details
STK11_HUMANMP2K6_HUMANBioGRID28205554 details
STK11_HUMANM3K5_HUMANBioGRID28205554 details
STK11_HUMANMK14_HUMANBioGRID28205554 details
STK11_HUMANMDM2_HUMANBioGRID28205554 details
STK11_HUMANPGFRA_HUMANBioGRID28205554 details
STK11_HUMANPK3CA_HUMANBioGRID28205554 details
STK11_HUMANSMAD1_HUMANBioGRID28205554 details
STK11_HUMANSOX4_HUMANBioGRID28205554 details
STK11_HUMANEPHA2_HUMANBioGRID28205554 details
STK11_HUMANTEAD2_HUMANBioGRID28205554 details
STK11_HUMANTERT_HUMANBioGRID28205554 details
STK11_HUMANTNR1A_HUMANBioGRID28205554 details
STK11_HUMANWT1_HUMANBioGRID28205554 details
STK11_HUMANMK03_HUMANBioGRID24412244 details
STK11_HUMANBAP1_HUMANBioGRID32819560 details
STK11_HUMANFKBP5_HUMANBioGRID, IntAct14676191 20562859 25036637 25852190 28514442 details
STK11_HUMANCAB39_HUMANBioGRID, DIP, HPRD, IntAct, MINT14676191 15561763 15733851 19513107 20562859 25241761 25852190 26479318 28514442 31217475 31554794 details
STK11_HUMANHS90A_HUMANBioGRID, IntAct14668798 14676191 21860411 22939624 25036637 28514442 details
STK11_HUMANCDC37_HUMANBioGRID, HPRD, IntAct12489981 14668798 14676191 20562859 21860411 25036637 details
STK11_HUMANPARD3_HUMANHPRD, IntAct14676191 details
STK11_HUMANHS90B_HUMANBioGRID, IntAct22939624 28514442 details
STK11_HUMANAAPK2_HUMANBioGRID, HPRD, IntAct10642499 19274086 25241761 details
STK11_HUMANKS6B1_HUMANBioGRID, HPRD, IntAct11297520 11853558 25241761 details
STK11_HUMANMLF1_HUMANIntAct25036637 details
STK11_HUMANBAG4_HUMANIntAct25036637 details
STK11_HUMANMLF2_HUMANIntAct25036637 details
STK11_HUMANSTIP1_HUMANIntAct25036637 details
STK11_HUMANCHIP_HUMANBioGRID, IntAct21860411 25036637 details
STK11_HUMANTEBP_HUMANIntAct25036637 details
STK11_HUMANHGFL_HUMANDIP24362629 details
STK11_HUMANLATS1_HUMANDIP24362629 details
STK11_HUMANMARK1_HUMANDIP, HPRD14517247 14976552 24362629 details
STK11_HUMANGSK3B_HUMANBioGRID22270359 details
STK11_HUMANP63_HUMANBioGRID21150337 details
STK11_HUMANSNAI1_HUMANBioGRID29601127 details
STK11_HUMANFXL14_HUMANBioGRID29601127 details
STK11_HUMANATM_HUMANBioGRID, HPRD11853558 12234250 15713674 details
STK11_HUMANCSN5_HUMANBioGRID30710502 details
STK11_HUMANFBX22_HUMANBioGRID31217475 details
STK11_HUMANTNKS1_HUMANBioGRID31554794 details
STK11_HUMANTNKS2_HUMANBioGRID31554794 details
STK11_HUMANRN146_HUMANBioGRID31554794 details
STK11_HUMANUBE2O_HUMANBioGRID31900314 details
STK11_HUMANKS6A3_HUMANHPRD11297520 11853558 details
STK11_HUMANKAPCA_HUMANHPRD11297520 11853558 details
STK11_HUMANKS6A5_HUMANHPRD11297520 details