Entity Details

Primary name TMEM127
Entity type gene
Source Source Link

Details

PrimaryID55654
RefseqGeneNG_027695
SymbolTMEM127
Nametransmembrane protein 127
Chromosome2
Location2q11.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-07-03
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsTM127_HUMAN

GO terms

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GOName
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0007032 endosome organization
GO:0008285 negative regulation of cell population proliferation
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031267 small GTPase binding
GO:0032006 regulation of TOR signaling
GO:0032007 negative regulation of TOR signaling

Diseases

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Disease IDSourceNameDescription
171300 OMIMPheochromocytoma (PCC)A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

5 interactions