Entity Details

Primary name STAR
Entity type gene
Source Source Link

Details

PrimaryID6770
RefseqGeneNG_011827
SymbolSTAR
Namesteroidogenic acute regulatory protein
Chromosome8
Location8p11.23
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-27
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSTAR_HUMAN

GO terms

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GOName
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol
GO:0006694 steroid biosynthetic process
GO:0006699 bile acid biosynthetic process
GO:0006700 C21-steroid hormone biosynthetic process
GO:0006703 estrogen biosynthetic process
GO:0007420 brain development
GO:0007584 response to nutrient
GO:0008203 cholesterol metabolic process
GO:0008211 glucocorticoid metabolic process
GO:0008584 male gonad development
GO:0009635 response to herbicide
GO:0010212 response to ionizing radiation
GO:0010288 response to lead ion
GO:0010628 positive regulation of gene expression
GO:0014823 response to activity
GO:0015485 cholesterol binding
GO:0016101 diterpenoid metabolic process
GO:0017143 insecticide metabolic process
GO:0018879 biphenyl metabolic process
GO:0018894 dibenzo-p-dioxin metabolic process
GO:0018958 phenol-containing compound metabolic process
GO:0018963 phthalate metabolic process
GO:0030061 mitochondrial crista
GO:0032367 intracellular cholesterol transport
GO:0032869 cellular response to insulin stimulus
GO:0035094 response to nicotine
GO:0035457 cellular response to interferon-alpha
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042747 circadian sleep/wake cycle, REM sleep
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043524 negative regulation of neuron apoptotic process
GO:0043627 response to estrogen
GO:0044321 response to leptin
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045471 response to ethanol
GO:0048168 regulation of neuronal synaptic plasticity
GO:0050769 positive regulation of neurogenesis
GO:0050810 regulation of steroid biosynthetic process
GO:0051412 response to corticosterone
GO:0060992 response to fungicide
GO:0061370 testosterone biosynthetic process
GO:0070859 positive regulation of bile acid biosynthetic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071236 cellular response to antibiotic
GO:0071276 cellular response to cadmium ion
GO:0071312 cellular response to alkaloid
GO:0071320 cellular response to cAMP
GO:0071333 cellular response to glucose stimulus
GO:0071346 cellular response to interferon-gamma
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0071373 cellular response to luteinizing hormone stimulus
GO:0071378 cellular response to growth hormone stimulus
GO:0071549 cellular response to dexamethasone stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071872 cellular response to epinephrine stimulus
GO:0120020 cholesterol transfer activity

Diseases

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Disease IDSourceNameDescription
201710 OMIMAdrenal hyperplasia 1 (AH1)The most severe form of adrenal hyperplasia. It is a condition characterized by onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma renin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. Affected individuals are phenotypic females irrespective of gonadal sex, and frequently die in infancy if mineralocorticoid and glucocorticoid replacement are not instituted. The disease is caused by variants affecting the gene represented in this entry.

Interactions

15 interactions