Entity Details

Primary name CERKL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ49MI3
EntryNameCERKL_HUMAN
FullNameCeramide kinase-like protein
TaxID9606
Evidenceevidence at protein level
Length558
SequenceStatuscomplete
DateCreated2005-12-20
DateModified2021-06-02

Ontological Relatives

GenesCERKL

GO terms

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GOName
GO:0001727 lipid kinase activity
GO:0001750 photoreceptor outer segment
GO:0001917 photoreceptor inner segment
GO:0003951 NAD+ kinase activity
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006665 sphingolipid metabolic process
GO:0016310 phosphorylation
GO:0030148 sphingolipid biosynthetic process
GO:0043066 negative regulation of apoptotic process
GO:0046625 sphingolipid binding
GO:0048471 perinuclear region of cytoplasm

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum
Golgi apparatus
Nucleus

Domains

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DomainNameCategoryType
IPR001206 Diacylglycerol kinase, catalytic domainDomainDomain
IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamilyFamilyHomologous superfamily
IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminalFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
608380 OMIMRetinitis pigmentosa 26 (RP26)A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. The disease is caused by variants affecting the gene represented in this entry.

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
CERKL_HUMANVHL_HUMANBioGRID26296657 details