Entity Details

Primary name KLH10_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6JEL2
EntryNameKLH10_HUMAN
FullNameKelch-like protein 10
TaxID9606
Evidenceevidence at protein level
Length608
SequenceStatuscomplete
DateCreated2004-09-27
DateModified2021-06-02

Ontological Relatives

GenesKLHL10

GO terms

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GOName
GO:0000902 cell morphogenesis
GO:0005737 cytoplasm
GO:0007286 spermatid development
GO:0008584 male gonad development
GO:0009566 fertilization
GO:0016567 protein ubiquitination
GO:0048808 male genitalia morphogenesis
GO:0048873 homeostasis of number of cells within a tissue

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000210 BTB/POZ domainDomainDomain
IPR006652 Kelch repeat type 1RepeatRepeat
IPR011333 SKP1/BTB/POZ domain superfamilyFamilyHomologous superfamily
IPR011705 BTB/Kelch-associatedDomainDomain
IPR015915 Kelch-type beta propellerFamilyHomologous superfamily
IPR017096 BTB-kelch proteinFamilyFamily
IPR030608 Kelch-like protein 10, BTB/POZ domainDomainDomain

Diseases

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Disease IDSourceNameDescription
615081 OMIMSpermatogenic failure 11 (SPGF11)An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. Oligozoospermia is usually observed in SPGF11 patients. In addition to oligozoospermia, teratozoospermia and moderate asthenozoospermia is observed in some cases. The disease is caused by variants affecting the gene represented in this entry.