Entity Details

Primary name TAF2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6P1X5
EntryNameTAF2_HUMAN
FullNameTranscription initiation factor TFIID subunit 2
TaxID9606
Evidenceevidence at protein level
Length1199
SequenceStatuscomplete
DateCreated2006-10-17
DateModified2021-06-02

Ontological Relatives

GenesTAF2

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000976 transcription cis-regulatory region binding
GO:0003682 chromatin binding
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0014070 response to organic cyclic compound
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0033276 transcription factor TFTC complex
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR037813 Transcription initiation factor TFIID subunit 2FamilyFamily
IPR042097 Aminopeptidase N-like , N-terminalFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615599 OMIMMental retardation, autosomal recessive 40 (MRT40)A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT40 affected individuals also show microcephaly, spasticity, thin corpus callosum, pyramidal signs. The disease is caused by variants affecting the gene represented in this entry.