Entity Details

Primary name MASP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00187
EntryNameMASP2_HUMAN
FullNameMannan-binding lectin serine protease 2
TaxID9606
Evidenceevidence at protein level
Length686
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesMASP2

GO terms

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GOName
GO:0001855 complement component C4b binding
GO:0001867 complement activation, lectin pathway
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0008233 peptidase activity
GO:0042802 identical protein binding
GO:0048306 calcium-dependent protein binding
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000436 Sushi/SCR/CCP domainDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR000859 CUB domainDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR035914 Spermadhesin, CUB domain superfamilyFamilyHomologous superfamily
IPR035976 Sushi/SCR/CCP superfamilyFamilyHomologous superfamily
IPR037571 Mannan-binding lectin-associated serine peptidase 2FamilyFamily
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
613791 OMIMMASP2 deficiency (MASPD)A disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB04527 beta-HydroxyasparagineDrugbanksmall molecule