Entity Details

Primary name PHIP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8WWQ0
EntryNamePHIP_HUMAN
FullNamePH-interacting protein
TaxID9606
Evidenceevidence at protein level
Length1821
SequenceStatuscomplete
DateCreated2007-08-21
DateModified2021-06-02

Ontological Relatives

GenesPHIP

GO terms

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GOName
GO:0001932 regulation of protein phosphorylation
GO:0005158 insulin receptor binding
GO:0005634 nucleus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007010 cytoskeleton organization
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008360 regulation of cell shape
GO:0022604 regulation of cell morphogenesis
GO:0043066 negative regulation of apoptotic process
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0045840 positive regulation of mitotic nuclear division
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0070577 lysine-acetylated histone binding
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001487 BromodomainDomainDomain
IPR001680 WD40 repeatRepeatRepeat
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR018359 Bromodomain, conserved siteSiteConserved site
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR028738 PH-interacting proteinFamilyFamily
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily
IPR036427 Bromodomain-like superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617991 OMIMChung-Jansen syndrome (CHUJANS)An autosomal dominant disorder characterized by developmental delay, intellectual disability, autistic features, anxiety, hypotonia, obesity, and dysmorphic features. The disease is caused by variants affecting the gene represented in this entry.