Entity Details

Primary name BAP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92560
EntryNameBAP1_HUMAN
FullNameUbiquitin carboxyl-terminal hydrolase BAP1
TaxID9606
Evidenceevidence at protein level
Length729
SequenceStatuscomplete
DateCreated2005-07-05
DateModified2021-06-02

Ontological Relatives

GenesBAP1

GO terms

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GOName
GO:0001558 regulation of cell growth
GO:0003682 chromatin binding
GO:0004843 thiol-dependent deubiquitinase
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006302 double-strand break repair
GO:0006464 cellular protein modification process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008233 peptidase activity
GO:0008285 negative regulation of cell population proliferation
GO:0010035 response to inorganic substance
GO:0016579 protein deubiquitination
GO:0035517 PR-DUB complex
GO:0035520 monoubiquitinated protein deubiquitination
GO:0035522 monoubiquitinated histone H2A deubiquitination
GO:0045892 negative regulation of transcription, DNA-templated
GO:0050727 regulation of inflammatory response
GO:0051726 regulation of cell cycle
GO:0061519 macrophage homeostasis
GO:0071108 protein K48-linked deubiquitination
GO:1900015 regulation of cytokine production involved in inflammatory response
GO:1903955 positive regulation of protein targeting to mitochondrion

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolaseDomainDomain
IPR036959 Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamilyFamilyHomologous superfamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily
IPR041507 Peptidase C12, C-terminal domainDomainDomain

Diseases

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Disease IDSourceNameDescription
614327 OMIMTumor predisposition syndrome (TPDS)A condition characterized by predisposition to develop a variety of tumors, including benign melanocytic tumors as well as several malignant tumors, including uveal melanoma, cutaneous melanoma, malignant mesothelioma on exposure to asbestos, lung adenocarcinoma and meningioma. The disease is caused by variants affecting the gene represented in this entry.
156240 OMIMMesothelioma, malignant (MESOM)An aggressive neoplasm of the serosal lining of the chest. It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. The gene represented in this entry is involved in disease pathogenesis.

Interactions

66 interactions

InteractorPartnerSourcesPublicationsLink
BAP1_HUMANBRCA1_HUMANBioGRID, HPRD, UniProt9528852 details
BAP1_HUMANASXL1_HUMANBioGRID, DIP, IntAct19615732 19815555 20436459 20805357 21642991 22897849 26416890 26437366 26739236 27705803 32683582 details
BAP1_HUMANASXL2_HUMANBioGRID, IntAct19615732 19815555 20805357 26186194 26416890 27705803 28514442 29284740 details
BAP1_HUMANFOXK1_HUMANBioGRID, IntAct, MINT19615732 19815555 20805357 25451922 25609649 27705803 32509391 details
BAP1_HUMANFOXK2_HUMANBioGRID, IntAct, MINT19615732 19815555 20805357 24748658 25451922 25609649 27705803 27773593 details
BAP1_HUMANHCFC1_HUMANBioGRID, IntAct, MINT19188440 19615732 19815555 20805357 21642991 22683710 24211834 24703950 26416890 27705803 30463901 32509391 details
BAP1_HUMANUBE2O_HUMANBioGRID, IntAct19615732 24703950 27705803 32509391 details
BAP1_HUMANBAG4_HUMANBioGRID, MINT25640309 details
BAP1_HUMANBCAR3_HUMANBioGRID, MINT25640309 details
BAP1_HUMANCASP8_HUMANBioGRID, MINT25640309 details
BAP1_HUMANESR1_HUMANBioGRID, MINT25640309 details
BAP1_HUMANIGF1R_HUMANBioGRID, MINT25640309 details
BAP1_HUMANNBN_HUMANBioGRID, MINT25640309 details
BAP1_HUMANPTPRJ_HUMANBioGRID, MINT25640309 details
BAP1_HUMANRBCC1_HUMANBioGRID, MINT25640309 details
BAP1_HUMANXRCC3_HUMANBioGRID, MINT25640309 details
BAP1_HUMANCBX5_HUMANBioGRID, IntAct27107012 details
BAP1_HUMANCBLC_HUMANBioGRID, IntAct27107012 details
BAP1_HUMANITPR3_HUMANBioGRID, DIP28614305 details
BAP1_HUMANH2A2C_HUMANBioGRID20436459 25283999 26739236 details
BAP1_HUMANTYY1_HUMANBioGRID20805357 details
BAP1_HUMANTRI63_HUMANBioGRID22626734 details
BAP1_HUMANUBP21_HUMANBioGRID22626734 details
BAP1_HUMANUBP15_HUMANBioGRID22626734 details
BAP1_HUMANUBP28_HUMANBioGRID22626734 details
BAP1_HUMANUBP2_HUMANBioGRID24703950 details
BAP1_HUMANH2A2A_HUMANBioGRID24703950 details
BAP1_HUMANUBC_HUMANBioGRID2532544 26416890 28935764 29576527 details
BAP1_HUMANM3K1_HUMANBioGRID25260751 details
BAP1_HUMANH2A1B_HUMANBioGRID26416890 30349006 details
BAP1_HUMANKLF5_HUMANBioGRID26419610 details
BAP1_HUMAN1433S_HUMANBioGRID29686263 details
BAP1_HUMANSTK11_HUMANBioGRID32819560 details
BAP1_HUMANRBBP7_HUMANBioGRID, IntAct19615732 29686263 32509391 details
BAP1_HUMANOGT1_HUMANBioGRID, IntAct19615732 20805357 24703950 26416890 27705803 32509391 details
BAP1_HUMANKDM1B_HUMANBioGRID, IntAct19615732 19815555 20805357 26496610 27705803 details
BAP1_HUMANHAT1_HUMANBioGRID, IntAct19615732 19815555 details
BAP1_HUMANCBX3_HUMANBioGRID, IntAct19615732 29686263 32509391 details
BAP1_HUMANIPO5_HUMANBioGRID, IntAct19615732 29686263 details
BAP1_HUMANIPO4_HUMANBioGRID, IntAct19615732 29686263 details
BAP1_HUMANANR17_HUMANBioGRID, IntAct19615732 19815555 details
BAP1_HUMANHSP72_HUMANBioGRID19815555 details
BAP1_HUMANPTEN_HUMANBioGRID15717329 details
BAP1_HUMANZC3HD_HUMANBioGRID20805357 details
BAP1_HUMANPRD10_HUMANBioGRID20805357 details
BAP1_HUMANGRP75_HUMANBioGRID20805357 details
BAP1_HUMANZN131_HUMANBioGRID20805357 details
BAP1_HUMANHS71A_HUMANBioGRID20805357 details
BAP1_HUMANHS71B_HUMANBioGRID20805357 details
BAP1_HUMANEFNA2_HUMANBioGRID20805357 details
BAP1_HUMANELF2_HUMANBioGRID20805357 details
BAP1_HUMANINO80_HUMANBioGRID25283999 31657441 details
BAP1_HUMANMCRS1_HUMANBioGRID26300492 32509391 details
BAP1_HUMANASXL3_HUMANBioGRID26647312 details
BAP1_HUMANLMBL2_HUMANBioGRID26437366 details
BAP1_HUMAN1433Z_HUMANBioGRID29686263 32509391 details
BAP1_HUMAN1433E_HUMANBioGRID29686263 details
BAP1_HUMAN1433B_HUMANBioGRID29686263 details
BAP1_HUMANLMAN2_HUMANBioGRID29686263 details
BAP1_HUMAN1433T_HUMANBioGRID29686263 details
BAP1_HUMAN1433F_HUMANBioGRID29686263 details
BAP1_HUMANKMT2C_HUMANBioGRID29785026 details
BAP1_HUMANKDM6A_HUMANBioGRID29785026 details
BAP1_HUMANCTNB1_HUMANBioGRID30323974 details
BAP1_HUMANCCDC6_HUMANBioGRID31447003 details
BAP1_HUMANDIDO1_HUMANBioGRID32509391 details