Entity Details

Primary name MRTFA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ969V6
EntryNameMRTFA_HUMAN
FullNameMyocardin-related transcription factor A
TaxID9606
Evidenceevidence at protein level
Length931
SequenceStatuscomplete
DateCreated2003-06-27
DateModified2021-06-02

Ontological Relatives

GenesMRTFA

GO terms

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GOName
GO:0003713 transcription coactivator activity
GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010735 positive regulation of transcription via serum response element binding
GO:0030036 actin cytoskeleton organization
GO:0043522 leucine zipper domain binding
GO:0044319 wound healing, spreading of cells
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051145 smooth muscle cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR003034 SAP domainDomainDomain
IPR004018 RPEL repeatRepeatRepeat
IPR029992 MKL/myocardin-like protein 1FamilyFamily
IPR036361 SAP domain superfamilyFamilyHomologous superfamily
IPR043451 Myocardin-likeFamilyFamily

Diseases

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Disease IDSourceNameDescription
618847 OMIMImmunodeficiency 66 (IMD66)An autosomal recessive primary immunologic disorder characterized by recurrent viral infections from infancy, associated with impaired neutrophil migration due to defects in cytoskeletal actin dynamics. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB08080 Latrunculin BDrugbanksmall molecule