Entity Details

Primary name CPLX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14810
EntryNameCPLX1_HUMAN
FullNameComplexin-1
TaxID9606
Evidenceevidence at protein level
Length134
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesCPLX1

GO terms

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GOName
GO:0000149 SNARE binding
GO:0005326 neurotransmitter transmembrane transporter activity
GO:0005829 cytosol
GO:0006836 neurotransmitter transport
GO:0006887 exocytosis
GO:0007268 chemical synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0016079 synaptic vesicle exocytosis
GO:0017075 syntaxin-1 binding
GO:0017157 regulation of exocytosis
GO:0030073 insulin secretion
GO:0030425 dendrite
GO:0031201 SNARE complex
GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane
GO:0043195 terminal bouton
GO:0043204 perikaryon
GO:0044305 calyx of Held
GO:0046928 regulation of neurotransmitter secretion
GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098794 postsynapse
GO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane
GO:0098978 glutamatergic synapse

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm
Perikaryon

Domains

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DomainNameCategoryType
IPR008849 SynaphinFamilyFamily

Diseases

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Disease IDSourceNameDescription
617976 OMIMDevelopmental and epileptic encephalopathy 63 (DEE63)A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE63 is an autosomal recessive disease with onset in infancy. The disease is caused by variants affecting the gene represented in this entry.