Entity Details

Primary name VPS25_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BRG1
EntryNameVPS25_HUMAN
FullNameVacuolar protein-sorting-associated protein 25
TaxID9606
Evidenceevidence at protein level
Length176
SequenceStatuscomplete
DateCreated2005-08-30
DateModified2021-06-02

Ontological Relatives

GenesVPS25

GO terms

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GOName
GO:0000814 ESCRT II complex
GO:0005198 structural molecule activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0010008 endosome membrane
GO:0016197 endosomal transport
GO:0016236 macroautophagy
GO:0036258 multivesicular body assembly
GO:0042803 protein homodimerization activity
GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0047485 protein N-terminus binding
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm
Endosome membrane
Nucleus

Domains

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DomainNameCategoryType
IPR008570 ESCRT-II complex, Vps25 subunitFamilyFamily
IPR014041 ESCRT-II complex, Vps25 subunit, N-terminal winged helixFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

23 interactions

InteractorPartnerSourcesPublicationsLink
VPS25_HUMANRHXF2_HUMANBioGRID, HPRD, IntAct16189514 details
VPS25_HUMANSNF8_HUMANBioGRID, HPRD, IntAct, MINT14505570 16189514 16371348 16973552 17010938 21516116 25416956 26344197 29892012 31515488 32296183 details
VPS25_HUMANMTNB_HUMANBioGRID, HPRD, IntAct16189514 details
VPS25_HUMANTRI27_HUMANBioGRID, IntAct25416956 29892012 32296183 details
VPS25_HUMANREL_HUMANBioGRID, IntAct25416956 29892012 details
VPS25_HUMANBEND5_HUMANBioGRID, IntAct25416956 details
VPS25_HUMANCRLF3_HUMANBioGRID, IntAct25416956 29892012 32296183 details
VPS25_HUMANCHMP6_HUMANBioGRID, HPRD, IntAct14505570 15511219 16371348 16730941 16856878 16973552 32296183 details
VPS25_HUMANLPP60_HUMANBioGRID, IntAct32296183 details
VPS25_HUMANSYCE1_HUMANBioGRID, IntAct32296183 details
VPS25_HUMANTAD2A_HUMANBioGRID, IntAct32296183 details
VPS25_HUMANSDCB2_HUMANBioGRID, IntAct32296183 details
VPS25_HUMANB9D2_HUMANBioGRID, IntAct32296183 details
VPS25_HUMANSPG21_HUMANBioGRID, IntAct32296183 details
VPS25_HUMANVPS36_HUMANBioGRID, HPRD, IntAct11278625 14505570 16371348 16973552 17010938 18539118 22863883 22939629 26344197 28514442 32296183 details
VPS25_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
VPS25_HUMANSEP14_HUMANBioGRID, IntAct32296183 details
VPS25_HUMANBPIA1_HUMANBioGRID, IntAct32296183 details
VPS25_HUMANGPR35_HUMANBioGRID, MINT28298427 details
VPS25_HUMANLT4R2_HUMANBioGRID, MINT28298427 details
VPS25_HUMANVPS25_HUMANBioGRID16371348 details
VPS25_HUMANSPY2_HUMANBioGRID21543492 details
VPS25_HUMANVPS28_HUMANBioGRID18539118 21543492 details