Entity Details

Primary name TRIM2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9C040
EntryNameTRIM2_HUMAN
FullNameTripartite motif-containing protein 2
TaxID9606
Evidenceevidence at protein level
Length744
SequenceStatuscomplete
DateCreated2002-06-06
DateModified2021-06-02

Ontological Relatives

GenesTRIM2

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0004842 ubiquitin-protein transferase activity
GO:0005737 cytoplasm
GO:0008270 zinc ion binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043523 regulation of neuron apoptotic process
GO:0061630 ubiquitin protein ligase activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000315 B-box-type zinc fingerDomainDomain
IPR001258 NHL repeatRepeatRepeat
IPR001298 Filamin/ABP280 repeatRepeatRepeat
IPR001841 Zinc finger, RING-typeDomainDomain
IPR003649 B-box, C-terminalDomainDomain
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR013017 NHL repeat, subgroupRepeatRepeat
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR017868 Filamin/ABP280 repeat-likeRepeatRepeat
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR027370 RING-type zinc-finger, LisH dimerisation motifDomainDomain

Diseases

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Disease IDSourceNameDescription
615490 OMIMCharcot-Marie-Tooth disease 2R (CMT2R)An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. The disease is caused by variants affecting the gene represented in this entry.

Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
TRIM2_HUMANSHPS1_HUMANBioGRID, HPRD, IntAct16189514 25416956 32296183 details
TRIM2_HUMANTNIK_HUMANBioGRID, IntAct17043677 31413325 details
TRIM2_HUMANUBE2U_HUMANBioGRID, IntAct19690564 details
TRIM2_HUMANUB2D1_HUMANBioGRID, IntAct19549727 21143188 details
TRIM2_HUMANUB2D2_HUMANBioGRID, IntAct19549727 details
TRIM2_HUMANUB2D3_HUMANBioGRID, IntAct19549727 details
TRIM2_HUMANUB2E1_HUMANBioGRID, IntAct19549727 details
TRIM2_HUMANUB2E2_HUMANBioGRID, IntAct19549727 details
TRIM2_HUMANUBE2H_HUMANBioGRID, IntAct19549727 details
TRIM2_HUMANUB2E3_HUMANBioGRID, IntAct19549727 details
TRIM2_HUMANUB2D4_HUMANBioGRID, IntAct19549727 details
TRIM2_HUMANUBE2W_HUMANBioGRID, IntAct19549727 details
TRIM2_HUMANLRC8E_HUMANBioGRID, IntAct, MINT21516116 32296183 details
TRIM2_HUMANUBAC1_HUMANBioGRID, IntAct, MINT21516116 25416956 32296183 details
TRIM2_HUMANCXB5_HUMANBioGRID, IntAct21988832 details
TRIM2_HUMANMAT1_HUMANBioGRID, IntAct22493164 details
TRIM2_HUMANTRIM8_HUMANBioGRID, IntAct22493164 details
TRIM2_HUMANCIB3_HUMANBioGRID, IntAct25416956 32296183 details
TRIM2_HUMANCDK20_HUMANBioGRID, IntAct26871637 details
TRIM2_HUMANKCTD7_HUMANBioGRID, IntAct32296183 details
TRIM2_HUMANTRIM3_HUMANBioGRID, IntAct28514442 32296183 details
TRIM2_HUMANCOG3_HUMANBioGRID, IntAct32296183 details
TRIM2_HUMANUBE2K_HUMANBioGRID, IntAct19549727 32814053 details
TRIM2_HUMANDTBP1_HUMANBioGRID17043677 details
TRIM2_HUMANB2L11_HUMANBioGRID21478148 details
TRIM2_HUMANOTUB2_HUMANBioGRID23105109 details
TRIM2_HUMANTNAP3_HUMANBioGRID23105109 details
TRIM2_HUMANHS90B_HUMANIntAct22939624 details
TRIM2_HUMANFMR1_HUMANIntAct31413325 details
TRIM2_HUMANHMN1_HUMANBioGRID12670303 details
TRIM2_HUMANHS90A_HUMANBioGRID22939624 details
TRIM2_HUMANSNAI1_HUMANBioGRID32536816 details
TRIM2_HUMANMYO5A_HUMANHPRD11432975 details