Entity Details

Primary name VPP4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9HBG4
EntryNameVPP4_HUMAN
FullNameV-type proton ATPase 116 kDa subunit a isoform 4
TaxID9606
Evidenceevidence at protein level
Length840
SequenceStatuscomplete
DateCreated2003-11-14
DateModified2021-06-02

Ontological Relatives

GenesATP6V0A4

GO terms

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GOName
GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain
GO:0001503 ossification
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0006885 regulation of pH
GO:0007035 vacuolar acidification
GO:0007588 excretion
GO:0007605 sensory perception of sound
GO:0008286 insulin receptor signaling pathway
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0016471 vacuolar proton-transporting V-type ATPase complex
GO:0030670 phagocytic vesicle membrane
GO:0031526 brush border membrane
GO:0033572 transferrin transport
GO:0034220 ion transmembrane transport
GO:0045177 apical part of cell
GO:0046961 proton-transporting ATPase activity, rotational mechanism
GO:0051117 ATPase binding
GO:0070062 extracellular exosome
GO:0090383 phagosome acidification
GO:1902600 proton transmembrane transport

Subcellular Location

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Subcellular Location
Apical cell membrane

Domains

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DomainNameCategoryType
IPR002490 V-type ATPase, V0 complex, 116kDa subunit familyFamilyFamily
IPR026028 ATPase, V0 complex, subunit 116kDa, eukaryoticFamilyFamily

Diseases

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Disease IDSourceNameDescription
602722 OMIMRenal tubular acidosis, distal, autosomal recessive (RTADR)An autosomal recessive disease characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis. It is due to functional failure of alpha-intercalated cells of the cortical collecting duct of the distal nephron, where vectorial proton transport is required for urinary acidification. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01133 Tiludronic acidDrugbanksmall molecule

Interactions

5 interactions