Entity Details

Primary name RNF12_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NVW2
EntryNameRNF12_HUMAN
FullNameE3 ubiquitin-protein ligase RLIM
TaxID9606
Evidenceevidence at protein level
Length624
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesRLIM

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000209 protein polyubiquitination
GO:0003714 transcription corepressor activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0017053 transcription repressor complex
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046872 metal ion binding
GO:0060816 random inactivation of X chromosome
GO:0061630 ubiquitin protein ligase activity
GO:1900095 regulation of dosage compensation by inactivation of X chromosome

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
300978 OMIMTonne-Kalscheuer syndrome (TOKAS)An X-linked disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. The disease is caused by variants affecting the gene represented in this entry.

Interactions

43 interactions

InteractorPartnerSourcesPublicationsLink
RNF12_HUMANLDB2_HUMANHPRD, MINT10431247 11882901 details
RNF12_HUMANLDB1_HUMANBioGRID, HPRD, MINT11882901 17437998 19117995 20423330 details
RNF12_HUMANRBTN2_HUMANHPRD, MINT10431247 11882901 details
RNF12_HUMANUB2D1_HUMANBioGRID, IntAct19164295 19549727 22596162 26926424 30413534 details
RNF12_HUMANUB2D2_HUMANBioGRID, IntAct19549727 32416094 details
RNF12_HUMANUB2D3_HUMANBioGRID, IntAct19549727 details
RNF12_HUMANUB2E1_HUMANBioGRID, IntAct19549727 29235476 details
RNF12_HUMANUB2E2_HUMANBioGRID, IntAct18073335 19549727 32416094 details
RNF12_HUMANUB2D4_HUMANBioGRID, IntAct19549727 details
RNF12_HUMANRS14_HUMANBioGRID, IntAct21988832 details
RNF12_HUMANSNX17_HUMANBioGRID, IntAct21988832 details
RNF12_HUMANLNX2_HUMANBioGRID, IntAct22493164 details
RNF12_HUMANDLG1_HUMANMINT24550280 details
RNF12_HUMANSTAT6_HUMANBioGRID, IntAct20211142 details
RNF12_HUMANCREST_HUMANBioGRID, IntAct20211142 details
RNF12_HUMANLHX3_HUMANBioGRID, HPRD10431247 11882901 details
RNF12_HUMANRNF12_HUMANBioGRID19117995 26592444 details
RNF12_HUMANESR1_HUMANBioGRID, HPRD19117995 details
RNF12_HUMANUBC_HUMANBioGRID16196087 32416094 details
RNF12_HUMANREXO1_HUMANBioGRID22596162 details
RNF12_HUMANSMUF2_HUMANBioGRID21945933 details
RNF12_HUMANTERF1_HUMANBioGRID19164295 details
RNF12_HUMANTNAP3_HUMANBioGRID23105109 details
RNF12_HUMANSTMN1_HUMANBioGRID24686088 26317901 details
RNF12_HUMANMDM2_HUMANBioGRID26926424 details
RNF12_HUMANUBE2K_HUMANBioGRID26592444 32416094 details
RNF12_HUMANSMAD7_HUMANBioGRID29235476 details
RNF12_HUMANTF3B_HUMANBioGRID30413534 details
RNF12_HUMANASXL1_HUMANBioGRID32683582 details
RNF12_HUMANUBE2O_HUMANMINT23455153 details
RNF12_HUMANSIN3A_HUMANBioGRID, HPRD10431247 11882901 details
RNF12_HUMANPDLI1_HUMANBioGRID, HPRD11882901 19117995 details
RNF12_HUMANSIAH1_HUMANBioGRID18073335 details
RNF12_HUMANHDAC2_HUMANBioGRID22493095 details
RNF12_HUMANNR4A1_HUMANBioGRID24584437 details
RNF12_HUMANAXIN2_HUMANBioGRID24584437 details
RNF12_HUMANBAG6_HUMANBioGRID24981174 details
RNF12_HUMANZBT17_HUMANBioGRID29137325 details
RNF12_HUMANMYC_HUMANBioGRID29137325 details
RNF12_HUMANISL1_HUMANHPRD10431247 11882901 details
RNF12_HUMANLIMK1_HUMANHPRD10431247 details
RNF12_HUMANLHX2_HUMANHPRD10431247 details
RNF12_HUMANLHX1_HUMANHPRD11882901 details