Entity Details

Primary name AGRE2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UHX3
EntryNameAGRE2_HUMAN
FullNameAdhesion G protein-coupled receptor E2
TaxID9606
Evidenceevidence at protein level
Length823
SequenceStatuscomplete
DateCreated2004-03-01
DateModified2021-06-02

Ontological Relatives

GenesADGRE2

GO terms

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GOName
GO:0004930 G protein-coupled receptor activity
GO:0005509 calcium ion binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0016021 integral component of membrane
GO:0016477 cell migration
GO:0031256 leading edge membrane
GO:0032587 ruffle membrane
GO:0035374 chondroitin sulfate binding
GO:0043304 regulation of mast cell degranulation
GO:0071621 granulocyte chemotaxis

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000203 GPS motifDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR000832 GPCR, family 2, secretin-likeFamilyFamily
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR003056 GPCR, family 2, ADGRE2/ADGRE5FamilyFamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR017981 GPCR, family 2-likeDomainDomain
IPR017983 GPCR, family 2, secretin-like, conserved siteSiteConserved site
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site

Diseases

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Disease IDSourceNameDescription
125630 OMIMVibratory urticaria (VBU)An autosomal dominant disorder characterized by localized hives and systemic manifestations in response to dermal vibration, with coincident degranulation of mast cells and increased histamine levels in serum. The disease is caused by variants affecting the gene represented in this entry.