Entity Details

Primary name SHAN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UPX8
EntryNameSHAN2_HUMAN
FullNameSH3 and multiple ankyrin repeat domains protein 2
TaxID9606
Evidenceevidence at protein level
Length1470
SequenceStatuscomplete
DateCreated2002-07-26
DateModified2021-06-02

Ontological Relatives

GenesSHANK2

GO terms

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GOName
GO:0001750 photoreceptor outer segment
GO:0001917 photoreceptor inner segment
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007416 synapse assembly
GO:0007612 learning
GO:0008284 positive regulation of cell population proliferation
GO:0014069 postsynaptic density
GO:0016324 apical plasma membrane
GO:0017124 SH3 domain binding
GO:0030160 synaptic receptor adaptor activity
GO:0030426 growth cone
GO:0030534 adult behavior
GO:0031526 brush border membrane
GO:0035176 social behavior
GO:0035255 ionotropic glutamate receptor binding
GO:0035331 negative regulation of hippo signaling
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0048854 brain morphogenesis
GO:0051124 synaptic assembly at neuromuscular junction
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060170 ciliary membrane
GO:0060291 long-term synaptic potentiation
GO:0060292 long-term synaptic depression
GO:0060997 dendritic spine morphogenesis
GO:0060999 positive regulation of dendritic spine development
GO:0071625 vocalization behavior
GO:0097107 postsynaptic density assembly
GO:2000311 regulation of AMPA receptor activity
GO:2000463 positive regulation of excitatory postsynaptic potential

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell junction
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR001660 Sterile alpha motif domainDomainDomain
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR041489 PDZ domain 6DomainDomain

Diseases

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Disease IDSourceNameDescription
613436 OMIMAutism 17 (AUTS17)A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
SHAN2_HUMANPLCG1_HUMANIntAct17474147 details
SHAN2_HUMANCRK_HUMANIntAct17474147 details
SHAN2_HUMANSRC_HUMANIntAct17474147 details
SHAN2_HUMANGRB2_HUMANIntAct17474147 details
SHAN2_HUMANNCK1_HUMANIntAct17474147 details
SHAN2_HUMANP85A_HUMANIntAct17474147 details
SHAN2_HUMANPP2BA_HUMANBioGRID, IntAct32296183 details
SHAN2_HUMANRHG12_HUMANBioGRID, IntAct32296183 details
SHAN2_HUMANHOME1_HUMANBioGRID, IntAct32296183 details
SHAN2_HUMANBAIP2_HUMANBioGRID, HPRD, IntAct12504591 32296183 details
SHAN2_HUMANRIPR3_HUMANBioGRID, IntAct32296183 details
SHAN2_HUMANBI2L1_HUMANDIP21098279 details
SHAN2_HUMANSRC8_HUMANBioGRID, HPRD9742101 details
SHAN2_HUMANDYN2_HUMANBioGRID, HPRD11583995 details
SHAN2_HUMANARHG7_HUMANBioGRID, HPRD12626503 32661924 details
SHAN2_HUMANDLGP1_HUMANBioGRID, HPRD10527873 10844022 details
SHAN2_HUMANDLG4_HUMANBioGRID, HPRD10527873 10844022 details
SHAN2_HUMANDLGP3_HUMANBioGRID10527873 details
SHAN2_HUMANDLGP4_HUMANBioGRID10527873 details
SHAN2_HUMANSHRPN_HUMANBioGRID23897824 details
SHAN2_HUMANAGRL2_HUMANHPRD10964907 details
SHAN2_HUMANAGRL1_HUMANHPRD10958799 10964907 details
SHAN2_HUMANSSR2_HUMANHPRD10373412 11087996 details
SHAN2_HUMANSL9A3_HUMANHPRD16293618 details
SHAN2_HUMANPDE4D_HUMANIntAct17244609 details
SHAN2_HUMANDYL2_HUMANBioGRID10844022 details
SHAN2_HUMANDYL1_HUMANBioGRID10844022 details
SHAN2_HUMANMYO5A_HUMANBioGRID10844022 details
SHAN2_HUMANRET_HUMANBioGRID28794017 details
SHAN2_HUMANGRB10_HUMANBioGRID28794017 details