Entity Details

Primary name TNPO3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y5L0
EntryNameTNPO3_HUMAN
FullNameTransportin-3
TaxID9606
Evidenceevidence at protein level
Length923
SequenceStatuscomplete
DateCreated2004-08-16
DateModified2021-06-02

Ontological Relatives

GenesTNPO3

GO terms

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GOName
GO:0005635 nuclear envelope
GO:0005642 annulate lamellae
GO:0005737 cytoplasm
GO:0006606 protein import into nucleus
GO:0031267 small GTPase binding
GO:0042802 identical protein binding
GO:0043231 intracellular membrane-bounded organelle
GO:0061608 nuclear import signal receptor activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus envelope

Domains

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DomainNameCategoryType
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR013598 Exportin-1/Importin-beta-likeDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
608423 OMIMMuscular dystrophy, limb-girdle, autosomal dominant 2 (LGMDD2)An autosomal dominant myopathy characterized by proximal muscle weakness primarily affecting the lower limbs, but also affecting the upper limbs in most patients. Affected individuals also have distal muscle weakness of the hands and lower leg muscles. The disease has generally a benign clinical course but some individuals with childhood or juvenile onset manifest severe widespread myopathy, leading to wheelchair dependency and respiratory insufficiency. Muscle biopsy shows dystrophic changes with abnormal nuclei, rimmed vacuoles, and filamentous inclusions. The disease is caused by variants affecting the gene represented in this entry.

Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
TNPO3_HUMANSMUF2_HUMANBioGRID, HPRD, MINT15231748 details
TNPO3_HUMANUBE2S_HUMANIntAct19549727 details
TNPO3_HUMANTNPO3_HUMANUniProt22872640 details
TNPO3_HUMANCHMP3_HUMANBioGRID, HPRD, IntAct16730941 details
TNPO3_HUMANCHM1B_HUMANIntAct16730941 details
TNPO3_HUMANCHM2A_HUMANIntAct16730941 details
TNPO3_HUMANCHM4A_HUMANIntAct16730941 details
TNPO3_HUMANCHMP6_HUMANIntAct16730941 details
TNPO3_HUMANKCC2D_HUMANBioGRID, IntAct32296183 details
TNPO3_HUMANNDKA_HUMANBioGRID, IntAct32296183 details
TNPO3_HUMANKCC2G_HUMANBioGRID, IntAct32296183 details
TNPO3_HUMANKCC2B_HUMANBioGRID, IntAct32296183 details
TNPO3_HUMANICA1L_HUMANBioGRID, IntAct32296183 details
TNPO3_HUMANSSX2_HUMANBioGRID, IntAct32296183 details
TNPO3_HUMANCLPP_HUMANBioGRID, IntAct32296183 details
TNPO3_HUMANPPR1C_HUMANBioGRID, IntAct32296183 details
TNPO3_HUMANBLMH_HUMANBioGRID, IntAct32296183 details
TNPO3_HUMANK2C75_HUMANBioGRID, IntAct32296183 details
TNPO3_HUMANGCH1_HUMANBioGRID, IntAct32296183 details
TNPO3_HUMANKR108_HUMANBioGRID, IntAct32296183 details
TNPO3_HUMANECI2_HUMANBioGRID, IntAct32296183 details
TNPO3_HUMANMEOX2_HUMANBioGRID32296183 details
TNPO3_HUMANSRSF1_HUMANHPRD10366588 10713112 details
TNPO3_HUMANTRA2B_HUMANHPRD10713112 details
TNPO3_HUMANTP4A3_HUMANIntAct17353931 details
TNPO3_HUMANMYC_HUMANIntAct17353931 details
TNPO3_HUMANNEK6_HUMANIntAct17353931 details
TNPO3_HUMANSTOM_HUMANBioGRID, IntAct27173435 unassigned1312 details
TNPO3_HUMANCAH9_HUMANBioGRID23181366 details
TNPO3_HUMANEGFR_HUMANBioGRID23956138 24797263 details