Entity Details

Primary name CDC45_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75419
EntryNameCDC45_HUMAN
FullNameCell division control protein 45 homolog
TaxID9606
Evidenceevidence at protein level
Length566
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesCDC45

GO terms

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GOName
GO:0000076 DNA replication checkpoint signaling
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000727 double-strand break repair via break-induced replication
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0031261 DNA replication preinitiation complex
GO:0031938 regulation of chromatin silencing at telomere
GO:0036064 ciliary basal body
GO:1902977 mitotic DNA replication preinitiation complex assembly

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR003874 CDC45 familyFamilyFamily

Diseases

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Disease IDSourceNameDescription
617063 OMIMMeier-Gorlin syndrome 7 (MGORS7)A form of Meier-Gorlin syndrome, a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. MGORS7 inheritance is autosomal recessive. The disease is caused by variants affecting the gene represented in this entry.

Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
CDC45_HUMANMCM10_HUMANBioGRID, HPRD, IntAct15232106 details
CDC45_HUMANORC5_HUMANBioGRID, HPRD, IntAct15232106 details
CDC45_HUMANORC3_HUMANBioGRID, HPRD, IntAct15232106 details
CDC45_HUMANCDN1A_HUMANBioGRID, HPRD, IntAct15232106 25241761 details
CDC45_HUMANCDN2A_HUMANBioGRID, IntAct15232106 details
CDC45_HUMANTOPB1_HUMANBioGRID, IntAct17887956 20065034 details
CDC45_HUMANTPPC3_HUMANBioGRID, IntAct21988832 details
CDC45_HUMANKCC1G_HUMANBioGRID, IntAct21988832 details
CDC45_HUMANCEP55_HUMANBioGRID, IntAct25416956 31515488 32296183 details
CDC45_HUMANZRAN1_HUMANBioGRID, IntAct32296183 details
CDC45_HUMANDDT4L_HUMANIntAct32296183 details
CDC45_HUMANRAB4B_HUMANBioGRID, IntAct32296183 details
CDC45_HUMANMCM6_HUMANBioGRID, DIP12614612 19805216 details
CDC45_HUMANMCM2_HUMANBioGRID, DIP19805216 22374673 26167883 30392930 details
CDC45_HUMANSLD5_HUMANBioGRID, DIP19805216 22374673 details
CDC45_HUMANORC2_HUMANBioGRID, HPRD12614612 9660782 details
CDC45_HUMANMCM3_HUMANBioGRID, HPRD12614612 27621311 details
CDC45_HUMANORC1_HUMANBioGRID12614612 details
CDC45_HUMANORC6_HUMANBioGRID12614612 details
CDC45_HUMANMCM7_HUMANBioGRID, HPRD10518787 12614612 16912045 details
CDC45_HUMANDPOLA_HUMANBioGRID, HPRD10518787 details
CDC45_HUMANARF_HUMANBioGRID, HPRD15232106 details
CDC45_HUMANUBC_HUMANBioGRID28190767 details
CDC45_HUMANCSK_HUMANBioGRID14625311 details
CDC45_HUMANMK03_HUMANBioGRID14625311 details
CDC45_HUMANLCK_HUMANBioGRID14625311 details
CDC45_HUMANT22D1_HUMANIntAct17353931 details
CDC45_HUMANPP4C_HUMANIntAct17353931 details
CDC45_HUMANCIAO1_HUMANIntAct17353931 details
CDC45_HUMANCLSPN_HUMANMINT23910567 details
CDC45_HUMANRFA2_HUMANBioGRID, MINT20679368 23910567 details
CDC45_HUMANMCM4_HUMANBioGRID16902406 details
CDC45_HUMANCCL2_HUMANBioGRID21383955 details
CDC45_HUMANH31_HUMANBioGRID20818375 details
CDC45_HUMANCDK2_HUMANBioGRID15753125 details
CDC45_HUMANDTD1_HUMANBioGRID20065034 details
CDC45_HUMANRECQ4_HUMANBioGRID19696745 29229926 details
CDC45_HUMANESCO2_HUMANBioGRID30100344 details
CDC45_HUMANCHK1_HUMANBioGRID25049228 details
CDC45_HUMANSHLD2_HUMANBioGRID30154076 details
CDC45_HUMANCDK4_HUMANHPRD15232106 details