Entity Details

Primary name CRYAA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02489
EntryNameCRYAA_HUMAN
FullNameAlpha-crystallin A chain
TaxID9606
Evidenceevidence at protein level
Length173
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0005198 structural molecule activity
GO:0005212 structural constituent of eye lens
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007601 visual perception
GO:0032387 negative regulation of intracellular transport
GO:0032991 protein-containing complex
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0046872 metal ion binding
GO:0050821 protein stabilization
GO:0050896 response to stimulus
GO:0051082 unfolded protein binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001436 Alpha crystallin/Small heat shock protein, animal typeFamilyFamily
IPR002068 Alpha crystallin/Hsp20 domainDomainDomain
IPR003090 Alpha-crystallin, N-terminalDomainDomain
IPR008978 HSP20-like chaperoneFamilyHomologous superfamily
IPR012274 Alpha-crystallin, subunit AFamilyFamily

Diseases

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Interactions

22 interactions

InteractorPartnerSourcesPublicationsLink
CRYAA_HUMANCRBB2_HUMANBioGRID, HPRD, MINT, UniProt11700327 12601044 details
CRYAA_HUMANCRGC_HUMANBioGRID, HPRD, MINT, UniProt11700327 12601044 15322286 details
CRYAA_HUMANCRYAB_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt11700327 12601044 16142923 16760894 17260942 18401461 18639655 19651604 22085609 22153508 22427585 23188086 25416956 25694240 25910212 26657544 28919577 32296183 details
CRYAA_HUMANHSPB1_HUMANBioGRID, HPRD, MINT, UniProt11700327 12601044 details
CRYAA_HUMANCRYAA_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt11700327 12601044 17724207 18639655 19651604 22085609 22427585 25416956 32296183 details
CRYAA_HUMANSDCB1_HUMANBioGRID, IntAct25416956 31515488 32296183 details
CRYAA_HUMANNTAQ1_HUMANBioGRID, IntAct25416956 31515488 32296183 details
CRYAA_HUMANGORS2_HUMANBioGRID, IntAct25416956 29892012 31515488 32296183 details
CRYAA_HUMANSPG21_HUMANBioGRID, IntAct25416956 31515488 32296183 details
CRYAA_HUMANCRBA4_HUMANIntAct31254514 details
CRYAA_HUMANEGFL8_HUMANIntAct32814053 details
CRYAA_HUMANCRYA2_HUMANBioGRID, HPRD11700327 12601044 17724207 18639655 22085609 22427585 25416956 32296183 details
CRYAA_HUMANCRGD_HUMANBioGRID12601044 22655036 details
CRYAA_HUMANHSPB2_HUMANBioGRID12601044 details
CRYAA_HUMANB2CL1_HUMANBioGRID, HPRD14752512 details
CRYAA_HUMANBAX_HUMANBioGRID14752512 details
CRYAA_HUMANCRBA1_HUMANBioGRID19401464 26657544 details
CRYAA_HUMANMIP_HUMANBioGRID, HPRD18004741 8910261 details
CRYAA_HUMANCISY_HUMANHPRD11377425 details
CRYAA_HUMANQOR_HUMANHPRD11672428 details
CRYAA_HUMANLALBA_HUMANHPRD9346914 details
CRYAA_HUMANALBU_HUMANHPRD9618718 details