Entity Details

Primary name HLAA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04439
EntryNameHLAA_HUMAN
FullNameHLA class I histocompatibility antigen, A alpha chain
TaxID9606
Evidenceevidence at protein level
Length365
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesHLA-A

GO terms

Show/Hide Table
GOName
GO:0000139 Golgi membrane
GO:0001913 T cell mediated cytotoxicity
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002419 T cell mediated cytotoxicity directed against tumor cell target
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0002485 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
GO:0002726 positive regulation of T cell cytokine production
GO:0003723 RNA binding
GO:0005102 signaling receptor binding
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005797 Golgi medial cisterna
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0016032 viral process
GO:0016045 detection of bacterium
GO:0016567 protein ubiquitination
GO:0019731 antibacterial humoral response
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0030670 phagocytic vesicle membrane
GO:0030881 beta-2-microglobulin binding
GO:0031901 early endosome membrane
GO:0032729 positive regulation of interferon-gamma production
GO:0036037 CD8-positive, alpha-beta T cell activation
GO:0042270 protection from natural killer cell mediated cytotoxicity
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042605 peptide antigen binding
GO:0042608 T cell receptor binding
GO:0042610 CD8 receptor binding
GO:0042612 MHC class I protein complex
GO:0042824 MHC class I peptide loading complex
GO:0046977 TAP binding
GO:0050776 regulation of immune response
GO:0050830 defense response to Gram-positive bacterium
GO:0050852 T cell receptor signaling pathway
GO:0055038 recycling endosome membrane
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0062061 TAP complex binding
GO:0070062 extracellular exosome
GO:0070971 endoplasmic reticulum exit site
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation
GO:2000568 positive regulation of memory T cell activation
GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Endoplasmic reticulum membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR001039 MHC class I alpha chain, alpha1 alpha2 domainsDomainDomain
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR010579 MHC class I, alpha chain, C-terminalDomainDomain
IPR011161 MHC class I-like antigen recognition-likeDomainDomain
IPR011162 MHC classes I/II-like antigen recognition proteinFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR037055 MHC class I-like antigen recognition-like superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
222100 OMIMDiabetes mellitus, insulin-dependent (IDDM)A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
126200 OMIMMultiple sclerosis (MS)A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.

Drugs

Show/Hide Table
DrugNameSourceType
DB02740 3-Indolebutyric AcidDrugbanksmall molecule
DB06226 Nelipepimut-SDrugbankbiotech
DB11294 Coccidioides immitis spheruleDrugbankbiotech

Interactions

62 interactions

InteractorPartnerSourcesPublicationsLink
HLAA_HUMANB2MG_HUMANBioGRID, HPRD, IntAct, MINT11502003 1448153 20831383 20844028 24163410 26439010 27649529 8805302 93026 details
HLAA_HUMANSTAT3_HUMANBioGRID, IntAct21988832 details
HLAA_HUMANZDH17_HUMANBioGRID, IntAct24705354 details
HLAA_HUMANKI3L2_HUMANBioGRID, HPRD, IntAct24018270 8617928 8760804 details
HLAA_HUMANKI2S4_HUMANIntAct24018270 details
HLAA_HUMANCCR9_HUMANBioGRID, MINT28298427 details
HLAA_HUMANBUD31_HUMANBioGRID, MINT28298427 details
HLAA_HUMANMEP1B_HUMANUniProt27180358 details
HLAA_HUMANCD8A_HUMANBioGRID, HPRD10809759 9177355 details
HLAA_HUMANMAGA4_HUMANBioGRID, HPRD11502003 21815906 details
HLAA_HUMANMAGA1_HUMANBioGRID, HPRD8647853 details
HLAA_HUMANBAP31_HUMANBioGRID, HPRD11163199 17056546 19342655 34079125 details
HLAA_HUMANCALR_HUMANBioGRID15383281 details
HLAA_HUMANMEOX2_HUMANBioGRID24722188 details
HLAA_HUMANGPR35_HUMANBioGRID28298427 details
HLAA_HUMANLT4R2_HUMANBioGRID28298427 details
HLAA_HUMANHLAC_HUMANBioGRID, IntAct17353931 26186194 28514442 details
HLAA_HUMANHYOU1_HUMANIntAct17353931 details
HLAA_HUMANHLAA_HUMANHPRD, IntAct12853576 17353931 8617928 8760804 9531263 details
HLAA_HUMANMIC13_HUMANIntAct17353931 details
HLAA_HUMANHLAB_HUMANBioGRID, IntAct17353931 26186194 28514442 details
HLAA_HUMANSMC2_HUMANIntAct17353931 26439010 details
HLAA_HUMANHLAG_HUMANBioGRID, IntAct17353931 28514442 details
HLAA_HUMANSSRD_HUMANIntAct17353931 details
HLAA_HUMANAT2A3_HUMANIntAct17353931 details
HLAA_HUMANUGGG2_HUMANIntAct17353931 details
HLAA_HUMANEFHD1_HUMANIntAct17353931 details
HLAA_HUMANPDIA3_HUMANHPRD, MINT17467700 9545232 details
HLAA_HUMANTPSNR_HUMANIntAct24163410 26439010 details
HLAA_HUMANTPSN_HUMANBioGRID, HPRD, IntAct11884415 24163410 26439010 8769474 details
HLAA_HUMANKI3S1_HUMANIntAct27649529 details
HLAA_HUMANLIRB2_HUMANIntAct27649529 details
HLAA_HUMANI12R2_HUMANIntAct28514442 details
HLAA_HUMANCALX_HUMANBioGRID, HPRD, IntAct17467700 29568061 details
HLAA_HUMANKAP0_HUMANBioGRID, HPRD, IntAct31980649 6333425 details
HLAA_HUMANDERL1_HUMANBioGRID, HPRD15215855 21245296 34079125 details
HLAA_HUMANTAP1_HUMANBioGRID11884415 17055437 details
HLAA_HUMANCOPB_HUMANBioGRID11884415 details
HLAA_HUMANCOPG1_HUMANBioGRID11884415 details
HLAA_HUMANSYVN1_HUMANBioGRID21245296 details
HLAA_HUMANUB2J1_HUMANBioGRID21245296 details
HLAA_HUMANPSMD2_HUMANBioGRID21245296 details
HLAA_HUMANTRAM1_HUMANBioGRID19121997 details
HLAA_HUMANS61A1_HUMANBioGRID14644099 details
HLAA_HUMANLMAN1_HUMANBioGRID19342655 34079125 details
HLAA_HUMANTAP2_HUMANBioGRID8805302 details
HLAA_HUMANATM_HUMANBioGRID20064447 details
HLAA_HUMANGNAS3_HUMANBioGRID9914489 details
HLAA_HUMANGNAS2_HUMANBioGRID9914489 details
HLAA_HUMANALEX_HUMANBioGRID9914489 details
HLAA_HUMANGNAS1_HUMANBioGRID9914489 details
HLAA_HUMANBAG6_HUMANBioGRID21636303 details
HLAA_HUMANTERA_HUMANBioGRID20702414 details
HLAA_HUMANTM129_HUMANBioGRID24807418 25030448 details
HLAA_HUMANHERC2_HUMANBioGRID25476789 details
HLAA_HUMANATG5_HUMANBioGRID33024031 details
HLAA_HUMANUBB_HUMANHPRD14722266 details
HLAA_HUMANDEK_HUMANHPRD9684994 details
HLAA_HUMANAPLP2_HUMANHPRD19184004 details
HLAA_HUMANERBB2_HUMANHPRD10593938 details
HLAA_HUMANKPCA_HUMANHPRD2941417 details
HLAA_HUMANSRC_HUMANHPRD6304688 6333425 details