Entity Details

Primary name GHR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10912
EntryNameGHR_HUMAN
FullNameGrowth hormone receptor
TaxID9606
Evidenceevidence at protein level
Length638
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesGHR

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0004896 cytokine receptor activity
GO:0004903 growth hormone receptor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006897 endocytosis
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0017046 peptide hormone binding
GO:0019221 cytokine-mediated signaling pathway
GO:0019530 taurine metabolic process
GO:0019838 growth factor binding
GO:0019901 protein kinase binding
GO:0019955 cytokine binding
GO:0031623 receptor internalization
GO:0032355 response to estradiol
GO:0032870 cellular response to hormone stimulus
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0040014 regulation of multicellular organism growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042445 hormone metabolic process
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042976 activation of Janus kinase activity
GO:0043235 receptor complex
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0046898 response to cycloheximide
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0060396 growth hormone receptor signaling pathway
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0070064 proline-rich region binding
GO:0070195 growth hormone receptor complex

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR003528 Long hematopoietin receptor, single chain, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015152 Growth hormone/erythropoietin receptor, ligand bindingDomainDomain
IPR025871 Growth hormone-binding proteinDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
604271 OMIMGrowth hormone insensitivity, partial (GHIP)A disease characterized by partial resistance to growth hormone resulting in short stature. Short stature is defined by a standing height more than 2 standard deviations below the mean (or below the 2.5 percentile) for sex and chronological age, compared with a well-nourished, healthy, genetically relevant population. The disease is caused by variants affecting the gene represented in this entry.
262500 OMIMLaron syndrome (LARS)A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. The disease is caused by variants affecting the gene represented in this entry.
143890 OMIMHypercholesterolemia, familial, 1 (FHCL1)A form of hypercholesterolemia, a disorder of lipoprotein metabolism characterized by elevated serum low-density lipoprotein (LDL) cholesterol levels, which result in excess deposition of cholesterol in tissues and leads to xanthelasma, xanthomas, accelerated atherosclerosis and increased risk of premature coronary heart disease. FHCL1 inheritance is autosomal dominant.

Drugs

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DrugNameSourceType
DB00052 SomatotropinDrugbankbiotech
DB00082 PegvisomantDrugbankbiotech
DB09098 SomatremDrugbankbiotech
DB15093 SomapacitanDrugbankbiotech

Interactions

54 interactions

InteractorPartnerSourcesPublicationsLink
GHR_HUMANNCOA6_HUMANHPRD, IntAct10567404 10866662 details
GHR_HUMANSOMA_HUMANBioGRID, IntAct17500058 24280222 31279174 7862673 8943276 9353194 details
GHR_HUMANPTN2_HUMANBioGRID, HPRD, IntAct12907755 details
GHR_HUMANPTPRB_HUMANBioGRID, IntAct12907755 19167335 details
GHR_HUMANPTN1_HUMANBioGRID, IntAct12907755 details
GHR_HUMANPTPRH_HUMANBioGRID, IntAct12907755 details
GHR_HUMANPTN9_HUMANBioGRID, IntAct12907755 details
GHR_HUMANPTN3_HUMANBioGRID, IntAct12907755 details
GHR_HUMANDUS7_HUMANBioGRID, IntAct12907755 details
GHR_HUMANCRK_HUMANIntAct17474147 details
GHR_HUMANGRB2_HUMANBioGRID, HPRD, IntAct17474147 9632636 details
GHR_HUMANNCK1_HUMANBioGRID, IntAct17474147 25241761 details
GHR_HUMANP85A_HUMANHPRD, IntAct17474147 9632636 details
GHR_HUMANPLCG1_HUMANBioGRID, IntAct17474147 9632636 details
GHR_HUMANPTPRC_HUMANIntAct19167335 details
GHR_HUMANPTPRK_HUMANIntAct19167335 details
GHR_HUMANPTPRJ_HUMANIntAct19167335 details
GHR_HUMANPTN12_HUMANIntAct19167335 details
GHR_HUMANPTN22_HUMANIntAct19167335 details
GHR_HUMANSTA5B_HUMANBioGRID, HPRD, IntAct25241761 8923468 details
GHR_HUMANGHR_HUMANBioGRID, DIP, HPRD16116438 24280222 8943276 details
GHR_HUMANSGTA_HUMANBioGRID, HPRD12735788 details
GHR_HUMANCISH_HUMANBioGRID, HPRD10585430 12586763 25505247 details
GHR_HUMANSOCS1_HUMANBioGRID, HPRD10585430 details
GHR_HUMANSOCS3_HUMANBioGRID, HPRD10585430 details
GHR_HUMANSOCS2_HUMANBioGRID, HPRD10585430 12135564 16675548 21980433 25505247 28967904 details
GHR_HUMANPTN11_HUMANBioGRID, HPRD10976913 9442080 9632636 details
GHR_HUMANSHC1_HUMANBioGRID, HPRD7535773 9632636 details
GHR_HUMANSTAT3_HUMANBioGRID, HPRD8923468 details
GHR_HUMANFBW1A_HUMANBioGRID17500058 22034227 23607312 details
GHR_HUMANPTN13_HUMANBioGRID12907755 details
GHR_HUMANCHIP_HUMANBioGRID22433856 details
GHR_HUMANSKP1_HUMANBioGRID23607312 25505247 details
GHR_HUMANP85B_HUMANBioGRID9632636 details
GHR_HUMANSRPK2_HUMANBioGRID26167880 details
GHR_HUMANCUL5_HUMANBioGRID25505247 details
GHR_HUMANNEDD8_HUMANBioGRID25505247 details
GHR_HUMANRBX2_HUMANBioGRID25505247 details
GHR_HUMANELOC_HUMANBioGRID25505247 details
GHR_HUMANELOB_HUMANBioGRID25505247 details
GHR_HUMANCUL1_HUMANBioGRID25505247 details
GHR_HUMANFBX31_HUMANBioGRID25505247 details
GHR_HUMANRBX1_HUMANBioGRID25505247 details
GHR_HUMANSTA5A_HUMANBioGRID, HPRD, IntAct25241761 8702683 details
GHR_HUMANJAK2_HUMANBioGRID, HPRD10502458 21347402 24280222 7540178 8063815 details
GHR_HUMANGRB10_HUMANBioGRID, HPRD9632636 details
GHR_HUMANJAK1_HUMANBioGRID, HPRD10502458 details
GHR_HUMANTYK2_HUMANBioGRID, HPRD10502458 details
GHR_HUMANFBW1B_HUMANBioGRID24280222 details
GHR_HUMANIGF1R_HUMANBioGRID15044591 details
GHR_HUMANPTN6_HUMANHPRD9632636 details
GHR_HUMANAP2A1_HUMANHPRD10551776 details
GHR_HUMANIRS1_HUMANHPRD7782332 details
GHR_HUMANSOM2_HUMANHPRD1955498 details