Entity Details

Primary name EF2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13639
EntryNameEF2_HUMAN
FullNameElongation factor 2
TaxID9606
Evidenceevidence at protein level
Length858
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesEEF2

GO terms

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GOName
GO:0002039 p53 binding
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002931 response to ischemia
GO:0003009 skeletal muscle contraction
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006414 translational elongation
GO:0007568 aging
GO:0008097 5S rRNA binding
GO:0014009 glial cell proliferation
GO:0016020 membrane
GO:0016235 aggresome
GO:0019901 protein kinase binding
GO:0032355 response to estradiol
GO:0034774 secretory granule lumen
GO:0034976 response to endoplasmic reticulum stress
GO:0035914 skeletal muscle cell differentiation
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042788 polysomal ribosome
GO:0043022 ribosome binding
GO:0043312 neutrophil degranulation
GO:0045121 membrane raft
GO:0045202 synapse
GO:0045296 cadherin binding
GO:0045471 response to ethanol
GO:0045727 positive regulation of translation
GO:0051015 actin filament binding
GO:0051593 response to folic acid
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen
GO:1990416 cellular response to brain-derived neurotrophic factor stimulus
GO:1990904 ribonucleoprotein complex
GO:2000767 positive regulation of cytoplasmic translation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000640 Elongation factor EFG, domain V-likeDomainDomain
IPR000795 Translational (tr)-type GTP-binding domainDomainDomain
IPR004161 Translation elongation factor EFTu-like, domain 2DomainDomain
IPR005225 Small GTP-binding protein domainDomainDomain
IPR005517 Translation elongation factor EFG/EF2, domain IVDomainDomain
IPR009000 Translation protein, beta-barrel domain superfamilyFamilyHomologous superfamily
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroupFamilyHomologous superfamily
IPR020568 Ribosomal protein S5 domain 2-type foldFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR031157 Tr-type G domain, conserved siteSiteConserved site
IPR035647 EF-G domain III/V-likeFamilyHomologous superfamily
IPR041095 Elongation Factor G, domain IIDomainDomain

Diseases

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Disease IDSourceNameDescription
609306 OMIMSpinocerebellar ataxia 26 (SCA26)A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB02059 Adenosine-5-DiphosphoriboseDrugbanksmall molecule
DB03223 DiphthamideDrugbanksmall molecule
DB04315 Guanosine-5'-DiphosphateDrugbanksmall molecule
DB08348 N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDEDrugbanksmall molecule
DB11823 EsketamineDrugbanksmall molecule
DB12688 Moxetumomab PasudotoxDrugbankbiotech

Interactions

44 interactions

InteractorPartnerSourcesPublicationsLink
EF2_HUMANDISC1_HUMANBioGRID, IntAct17043677 31413325 details
EF2_HUMANCDN2A_HUMANBioGRID, IntAct17955473 details
EF2_HUMANMLH1_HUMANBioGRID, IntAct20706999 details
EF2_HUMANEP300_HUMANBioGRID, MINT20808282 details
EF2_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
EF2_HUMANHSPB2_HUMANbhf-ucl26465331 details
EF2_HUMANEF2KT_HUMANBioGRID, IntAct23349634 25231979 26186194 28514442 details
EF2_HUMANHD_HUMANIntAct32814053 details
EF2_HUMANUCHL5_HUMANBioGRID21800051 details
EF2_HUMANEF2K_HUMANBioGRID, HPRD22669845 8386634 91085562 details
EF2_HUMANTCPB_HUMANBioGRID23190606 details
EF2_HUMANHNRPD_HUMANBioGRID15231747 details
EF2_HUMANARF_HUMANBioGRID17955473 details
EF2_HUMANESR1_HUMANBioGRID20348541 details
EF2_HUMANPTEN_HUMANBioGRID26561776 details
EF2_HUMANCPEB2_HUMANBioGRID22157746 details
EF2_HUMANSUMO2_HUMANBioGRID32786267 details
EF2_HUMANCBP_HUMANBioGRID32238831 details
EF2_HUMANRD23A_HUMANBioGRID, MINT16712842 details
EF2_HUMAN1433Z_HUMANMINT15161933 details
EF2_HUMANMAX_HUMANIntAct20195357 details
EF2_HUMANP53_HUMANBioGRID, HPRD, MINT12891704 22653443 32807901 details
EF2_HUMANAF9_HUMANBioGRID20431927 details
EF2_HUMANNOP56_HUMANBioGRID12777385 details
EF2_HUMANISG15_HUMANBioGRID16009940 33024031 details
EF2_HUMANHS90A_HUMANBioGRID16263121 details
EF2_HUMANITA4_HUMANBioGRID22623428 details
EF2_HUMANSEM1_HUMANBioGRID24515614 details
EF2_HUMANSEML_HUMANBioGRID24515614 details
EF2_HUMANSIR6_HUMANBioGRID24169447 details
EF2_HUMANGAN_HUMANBioGRID26460568 details
EF2_HUMANU2AF2_HUMANBioGRID26641092 details
EF2_HUMANZN598_HUMANBioGRID28685749 details
EF2_HUMANAKTIP_HUMANBioGRID27512140 details
EF2_HUMANCDC37_HUMANBioGRID16611982 details
EF2_HUMANSOX2_HUMANBioGRID21280222 details
EF2_HUMANPPIA_HUMANBioGRID25678563 details
EF2_HUMANBIN1_HUMANBioGRID31815296 details
EF2_HUMANCSPG4_HUMANBioGRID30131676 details
EF2_HUMANMAPK3_HUMANHPRD12171600 details
EF2_HUMANEF2_HUMANHPRD15835887 2318846 details
EF2_HUMANPP2AA_HUMANHPRD8386634 details
EF2_HUMANTRPM7_HUMANHPRD14594813 details
EF2_HUMANPPM1A_HUMANHPRD8386634 details