Entity Details

Primary name CD59_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13987
EntryNameCD59_HUMAN
FullNameCD59 glycoprotein
TaxID9606
Evidenceevidence at protein level
Length128
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesCD59

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001848 complement binding
GO:0001971 negative regulation of activation of membrane attack complex
GO:0005615 extracellular space
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007166 cell surface receptor signaling pathway
GO:0007596 blood coagulation
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0030133 transport vesicle
GO:0030449 regulation of complement activation
GO:0031362 anchored component of external side of plasma membrane
GO:0031982 vesicle
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0035579 specific granule membrane
GO:0043312 neutrophil degranulation
GO:0048208 COPII vesicle coating
GO:0070062 extracellular exosome
GO:0070821 tertiary granule membrane
GO:1903659 regulation of complement-dependent cytotoxicity

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR016054 Ly-6 antigen/uPA receptor-likeDomainDomain
IPR018363 CD59 antigen, conserved siteSiteConserved site
IPR027101 CD59 glycoproteinFamilyFamily

Diseases

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Disease IDSourceNameDescription
612300 OMIMHemolytic anemia, CD59-mediated, with or without polyneuropathy (HACD59)An autosomal recessive disorder characterized by infantile onset of chronic hemolysis and a relapsing-remitting polyneuropathy, often exacerbated by infection, and manifested as hypotonia, limb muscle weakness, and hyporeflexia. The disease is caused by variants affecting the gene represented in this entry.