Entity Details

Primary name BRAF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15056
EntryNameBRAF_HUMAN
FullNameSerine/threonine-protein kinase B-raf
TaxID9606
Evidenceevidence at protein level
Length766
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesBRAF

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0009887 animal organ morphogenesis
GO:0010628 positive regulation of gene expression
GO:0010828 positive regulation of glucose transmembrane transport
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070413 trehalose metabolism in response to stress
GO:0071277 cellular response to calcium ion
GO:0090150 establishment of protein localization to membrane
GO:0097110 scaffold protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR003116 Raf-like Ras-bindingDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
115150 OMIMCardiofaciocutaneous syndrome 1 (CFC1)A multiple congenital anomaly disorder characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The disease is caused by variants affecting the gene represented in this entry.
613706 OMIMNoonan syndrome 7 (NS7)A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. The disease is caused by variants affecting the gene represented in this entry.
613707 OMIMLEOPARD syndrome 3 (LPRD3)A disorder characterized by lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and sensorineural deafness. The disease is caused by variants affecting the gene represented in this entry.
114500 OMIMColorectal cancer (CRC)A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. The disease may be caused by variants affecting the gene represented in this entry.
605027 OMIMFamilial non-Hodgkin lymphoma (NHL)Cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss. The gene represented in this entry is involved in disease pathogenesis.
211980 OMIMLung cancer (LNCR)A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. The gene represented in this entry is involved in disease pathogenesis.

Drugs

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DrugNameSourceType
DB00398 SorafenibDrugbanksmall molecule
DB05190 XL281Drugbanksmall molecule
DB05984 RAF-265Drugbanksmall molecule
DB06999 PLX-4720Drugbanksmall molecule
DB07000 N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamideDrugbanksmall molecule
DB08553 (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oximeDrugbanksmall molecule
DB08881 VemurafenibDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB08912 DabrafenibDrugbanksmall molecule
DB11718 EncorafenibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB14840 RipretinibDrugbanksmall molecule

Interactions

73 interactions

InteractorPartnerSourcesPublicationsLink
BRAF_HUMAN1433B_HUMANBioGRID, HPRD, IntAct, MINT10931830 12620389 15324660 17353931 24255178 27034005 27684187 28514442 31980649 details
BRAF_HUMAN1433T_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 17979178 18332145 27034005 27684187 28514442 31015455 31980649 8668348 details
BRAF_HUMAN1433G_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 17979178 27034005 27684187 28205554 28514442 31980649 details
BRAF_HUMAN1433Z_HUMANBioGRID, HPRD, IntAct, MINT15161933 15324660 17353931 17979178 26496610 27034005 27684187 28205554 28514442 31980649 8668348 details
BRAF_HUMANTIM50_HUMANIntAct12620389 details
BRAF_HUMANMS18B_HUMANHPRD, IntAct12620389 details
BRAF_HUMANM3K1_HUMANMINT16810323 16888650 details
BRAF_HUMANBRAF_HUMANBioGRID, DIP, HPRD, IntAct, MINT16858395 17192257 1748651 17979178 19727074 22169110 22510884 25155755 25437913 28205554 31980649 7935374 details
BRAF_HUMAN1433S_HUMANBioGRID, IntAct, MINT15778465 27034005 27684187 28205554 31980649 details
BRAF_HUMANMP2K1_HUMANBioGRID, DIP, HPRD, IntAct16810323 16888650 17979178 18332145 19371126 20212043 23934108 24746704 25155755 25437913 25600339 26496610 27034005 27684187 28514442 31015455 31980649 7731720 8157000 8394352 8621729 9733801 details
BRAF_HUMAN1433F_HUMANBioGRID, HPRD, IntAct17979178 27034005 28514442 31980649 8668348 details
BRAF_HUMANARAF_HUMANBioGRID, DIP, IntAct17979178 20130576 25241761 28205554 28514442 31980649 details
BRAF_HUMANRAF1_HUMANBioGRID, DIP, HPRD, IntAct, MINT11325826 16803888 18332145 20130576 20141835 20212043 22169110 22510884 22605333 23153539 23680146 23934108 25155755 26466569 28514442 28806393 31015455 31980649 details
BRAF_HUMANTERF1_HUMANBioGRID, IntAct20936779 details
BRAF_HUMANPAK2_HUMANBioGRID, IntAct20936779 details
BRAF_HUMANGRDN_HUMANBioGRID, IntAct20936779 details
BRAF_HUMANAKT1_HUMANBioGRID, HPRD, IntAct10869359 11410590 25241761 28205554 details
BRAF_HUMANMK03_HUMANBioGRID, IntAct24412244 25241761 details
BRAF_HUMANCATL2_HUMANBioGRID, MINT24412244 details
BRAF_HUMANF16P1_HUMANBioGRID, MINT24412244 details
BRAF_HUMANDHB3_HUMANBioGRID, MINT24412244 details
BRAF_HUMANMAPK3_HUMANMINT24412244 details
BRAF_HUMANZN189_HUMANBioGRID, MINT24412244 details
BRAF_HUMANZN510_HUMANBioGRID, MINT24412244 details
BRAF_HUMANRASK_HUMANBioGRID, IntAct27034005 27684187 28205554 28514442 30194290 31980649 34079125 details
BRAF_HUMANRASH_HUMANBioGRID, DIP, HPRD, IntAct16803888 22605333 24441586 26165597 27034005 28205554 28514442 30194290 30639242 7706312 9154803 details
BRAF_HUMANIQGA1_HUMANBioGRID, DIP17563371 18567582 27034005 27684187 details
BRAF_HUMANRASN_HUMANBioGRID, DIP21478863 27034005 30194290 30639242 31015455 7499408 9368069 details
BRAF_HUMANKS6B2_HUMANBioGRID, MINT16810323 21625473 25324306 details
BRAF_HUMANRPGP1_HUMANBioGRID, HPRD10854065 11278445 details
BRAF_HUMANRAP1A_HUMANBioGRID, HPRD10454553 16507992 9560161 details
BRAF_HUMANNED4L_HUMANBioGRID19953087 31015455 details
BRAF_HUMANMK01_HUMANBioGRID, HPRD14654779 18567582 26285778 details
BRAF_HUMANBAD_HUMANBioGRID19667065 details
BRAF_HUMANMP2K7_HUMANBioGRID27034005 30082909 details
BRAF_HUMANSPY2_HUMANBioGRID19690147 details
BRAF_HUMANNANOG_HUMANBioGRID30595535 details
BRAF_HUMANITCH_HUMANBioGRID31015455 details
BRAF_HUMANPP2AA_HUMANBioGRID31015455 details
BRAF_HUMAN2ABA_HUMANBioGRID31015455 details
BRAF_HUMANAURKA_HUMANBioGRID28205554 details
BRAF_HUMANLATS2_HUMANBioGRID28205554 details
BRAF_HUMANMP2K3_HUMANBioGRID28205554 details
BRAF_HUMANMP2K6_HUMANBioGRID28205554 details
BRAF_HUMANRASF1_HUMANBioGRID28205554 details
BRAF_HUMANSTK11_HUMANBioGRID28205554 details
BRAF_HUMANTERT_HUMANBioGRID28205554 details
BRAF_HUMANPEBP1_HUMANBioGRID15886202 details
BRAF_HUMANCRBN_HUMANBioGRID32778845 details
BRAF_HUMANKPCA_HUMANMINT16810323 details
BRAF_HUMANKPCE_HUMANBioGRID, HPRD, MINT16810323 21625473 details
BRAF_HUMANKS6A2_HUMANMINT16810323 details
BRAF_HUMANMP2K2_HUMANBioGRID, HPRD, IntAct17979178 24746704 25600339 27034005 28514442 31980649 8668348 details
BRAF_HUMANHS90B_HUMANBioGRID, IntAct17979178 22939624 27684187 31980649 details
BRAF_HUMANKSR1_HUMANBioGRID, MINT18332145 22510884 details
BRAF_HUMANKSR2_HUMANMINT22510884 details
BRAF_HUMANTRAF3_HUMANIntAct23153539 details
BRAF_HUMANHS90A_HUMANBioGRID, IntAct22939624 27034005 27684187 28146421 31980649 details
BRAF_HUMANRASM_HUMANBioGRID, HPRD12138204 details
BRAF_HUMANRN149_HUMANBioGRID22628551 details
BRAF_HUMANBRAP_HUMANBioGRID18332145 details
BRAF_HUMANFBXW7_HUMANBioGRID26898828 details
BRAF_HUMANFNIP1_HUMANBioGRID27353360 details
BRAF_HUMANFNIP2_HUMANBioGRID27353360 details
BRAF_HUMANHSP74_HUMANBioGRID27034005 28146421 details
BRAF_HUMANTRAF2_HUMANBioGRID29748372 details
BRAF_HUMANSMUF2_HUMANBioGRID31015455 details
BRAF_HUMANWWP1_HUMANBioGRID31015455 details
BRAF_HUMANWWP2_HUMANBioGRID31015455 details
BRAF_HUMANTRAP1_HUMANBioGRID26084290 details
BRAF_HUMANRHEB_HUMANHPRD16803888 details
BRAF_HUMANKAPCA_HUMANHPRD11510412 details
BRAF_HUMANSGK1_HUMANHPRD10869359 11410590 details