Entity Details

Primary name RAC2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15153
EntryNameRAC2_HUMAN
FullNameRas-related C3 botulinum toxin substrate 2
TaxID9606
Evidenceevidence at protein level
Length192
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesRAC2

GO terms

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GOName
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005635 nuclear envelope
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0007015 actin filament organization
GO:0007163 establishment or maintenance of cell polarity
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008045 motor neuron axon guidance
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0010310 regulation of hydrogen peroxide metabolic process
GO:0010592 positive regulation of lamellipodium assembly
GO:0010810 regulation of cell-substrate adhesion
GO:0016601 Rac protein signal transduction
GO:0019887 protein kinase regulator activity
GO:0019901 protein kinase binding
GO:0030027 lamellipodium
GO:0030031 cell projection assembly
GO:0030670 phagocytic vesicle membrane
GO:0030865 cortical cytoskeleton organization
GO:0031410 cytoplasmic vesicle
GO:0032956 regulation of actin cytoskeleton organization
GO:0042129 regulation of T cell proliferation
GO:0042995 cell projection
GO:0043231 intracellular membrane-bounded organelle
GO:0043304 regulation of mast cell degranulation
GO:0043652 engulfment of apoptotic cell
GO:0045453 bone resorption
GO:0045454 cell redox homeostasis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051897 positive regulation of protein kinase B signaling
GO:0060263 regulation of respiratory burst
GO:0060753 regulation of mast cell chemotaxis
GO:0070062 extracellular exosome
GO:0071593 lymphocyte aggregation
GO:0090023 positive regulation of neutrophil chemotaxis
GO:1902622 regulation of neutrophil migration
GO:1903955 positive regulation of protein targeting to mitochondrion

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001806 Small GTPaseFamilyFamily
IPR003578 Small GTPase RhoFamilyFamily
IPR005225 Small GTP-binding protein domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
608203 OMIMImmunodeficiency 73A with defective neutrophil chemotaxis and leukocytosis (IMD73A)An autosomal dominant immunologic disorder characterized by onset of recurrent infections in early infancy, leukocytosis, neutrophilia, invasive infections, and poor wound healing. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00514 DextromethorphanDrugbanksmall molecule

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
RAC2_HUMANGDIR2_HUMANBioGRID, HPRD, MINT10655614 details
RAC2_HUMANNCF2_HUMANBioGRID, HPRD, MINT11090627 9624165 9642115 details
RAC2_HUMANADA22_HUMANBioGRID, IntAct21988832 details
RAC2_HUMANAFG32_HUMANBioGRID, MINT21900206 details
RAC2_HUMANSCG1_HUMANBioGRID, MINT21900206 details
RAC2_HUMANXIAP_HUMANMINT22117219 details
RAC2_HUMANHDAC7_HUMANBioGRID, IntAct32296183 details
RAC2_HUMANARFP2_HUMANBioGRID, HPRD, IntAct11346801 32296183 details
RAC2_HUMANPLD2_HUMANDIP22106281 details
RAC2_HUMANDOCK2_HUMANBioGRID, DIP, HPRD10559471 14737186 details
RAC2_HUMANCUL1_HUMANBioGRID, HPRD11445862 details
RAC2_HUMANDEFI6_HUMANBioGRID, HPRD15023524 details
RAC2_HUMANACTB_HUMANBioGRID, HPRD11027608 details
RAC2_HUMANICMT_HUMANBioGRID, HPRD9614111 details
RAC2_HUMANNOS2_HUMANBioGRID, HPRD11457725 details
RAC2_HUMANPAK2_HUMANBioGRID12176041 details
RAC2_HUMANGDIR1_HUMANBioGRID, HPRD11368848 11513578 9490022 details
RAC2_HUMANAGAP2_HUMANBioGRID22453919 details
RAC2_HUMANNOXA1_HUMANHPRD12716910 details
RAC2_HUMANCY24B_HUMANInnateDB22366891 details
RAC2_HUMANWASP_HUMANmbinfo14521508 details
RAC2_HUMANPAK1_HUMANmbinfo14521508 details
RAC2_HUMANRAC2_HUMANmbinfo9748241 details
RAC2_HUMANTP8L2_HUMANDIP22949657 details
RAC2_HUMANITA4_HUMANBioGRID22623428 details
RAC2_HUMANU2AF2_HUMANBioGRID26641092 details
RAC2_HUMANGDIA_HUMANHPRD9490022 details
RAC2_HUMANCDC42_HUMANHPRD9748241 details
RAC2_HUMANSMAD1_HUMANHPRD15761153 details
RAC2_HUMANSMAD4_HUMANHPRD15761153 details
RAC2_HUMANRTKN_HUMANHPRD12516569 details