Entity Details

Primary name TFE2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15923
EntryNameTFE2_HUMAN
FullNameTranscription factor E2-alpha
TaxID9606
Evidenceevidence at protein level
Length654
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesTCF3

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002326 B cell lineage commitment
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007399 nervous system development
GO:0008134 transcription factor binding
GO:0030183 B cell differentiation
GO:0030890 positive regulation of B cell proliferation
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0032991 protein-containing complex
GO:0033152 immunoglobulin V(D)J recombination
GO:0042803 protein homodimerization activity
GO:0043425 bHLH transcription factor binding
GO:0045666 positive regulation of neuron differentiation
GO:0045787 positive regulation of cell cycle
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051149 positive regulation of muscle cell differentiation
GO:0070644 vitamin D response element binding
GO:0070888 E-box binding
GO:0090575 RNA polymerase II transcription regulator complex
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:2000045 regulation of G1/S transition of mitotic cell cycle

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616941 OMIMAgammaglobulinemia 8, autosomal dominant (AGM8)A form of agammaglobulinemia, a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. The disease is caused by variants affecting the gene represented in this entry.

Interactions

93 interactions

InteractorPartnerSourcesPublicationsLink
TFE2_HUMANASCL1_HUMANBioGRID, IntAct10903890 15318167 details
TFE2_HUMANTAL1_HUMANBioGRID, DIP, HPRD, IntAct, MINT16407974 19497860 21179004 7568177 8159721 9507011 9824680 details
TFE2_HUMANCCDB1_HUMANIntAct10915743 details
TFE2_HUMANID1_HUMANBioGRID, HPRD, IntAct10915743 11591653 19125693 22354994 26496610 32296183 9242638 details
TFE2_HUMANID2_HUMANBioGRID, DIP, HPRD, IntAct10915743 11591653 19321746 22354994 26735018 28514442 9242638 details
TFE2_HUMANID3_HUMANBioGRID, HPRD, IntAct10915743 22354994 25416956 32296183 8759016 9242638 9525934 details
TFE2_HUMANA1AT_HUMANIntAct10915743 details
TFE2_HUMANMYOD1_HUMANBioGRID, HPRD, IntAct10915743 1649701 9001211 9050988 9184158 9242638 details
TFE2_HUMANTFE2_HUMANBioGRID, HPRD, IntAct10567574 10915743 12435739 15351717 1649701 22354994 2503252 28205554 7623842 8628307 8900141 8948587 9050988 9584154 details
TFE2_HUMANRL37_HUMANBioGRID, IntAct21988832 details
TFE2_HUMANTCAF1_HUMANBioGRID, IntAct25416956 32296183 details
TFE2_HUMANTWST2_HUMANBioGRID, IntAct32296183 details
TFE2_HUMANASCL3_HUMANBioGRID, HPRD, IntAct11784080 32296183 details
TFE2_HUMANHAND1_HUMANBioGRID, HPRD, IntAct10924525 11802795 16043483 32296183 details
TFE2_HUMANMYF6_HUMANBioGRID, IntAct28514442 9242638 details
TFE2_HUMANITF2_HUMANBioGRID, IntAct20211142 28514442 details
TFE2_HUMANMYOG_HUMANBioGRID, HPRD, IntAct1325437 2163343 26186194 28514442 9242638 details
TFE2_HUMANNDF1_HUMANBioGRID, IntAct14752053 26186194 28514442 details
TFE2_HUMANTAF4_HUMANDIP17483474 details
TFE2_HUMANPSMD9_HUMANHPRD, IntAct10567574 25009770 details
TFE2_HUMANMESP1_HUMANIntAct26694203 details
TFE2_HUMANTWST1_HUMANBioGRID, HPRD, IntAct10749989 11248247 20714342 22354994 details
TFE2_HUMANAT1A3_HUMANIntAct32814053 details
TFE2_HUMANPECA1_HUMANIntAct32814053 details
TFE2_HUMANPLD1_HUMANIntAct32814053 details
TFE2_HUMANRAB5A_HUMANIntAct32814053 details
TFE2_HUMANVIME_HUMANIntAct32814053 details
TFE2_HUMANHAND2_HUMANBioGRID, HPRD11812799 15351717 details
TFE2_HUMANHEN1_HUMANBioGRID12878195 details
TFE2_HUMANEP300_HUMANBioGRID, HPRD12435739 14752053 22207202 details
TFE2_HUMANCBP_HUMANBioGRID, HPRD12435739 15507449 22207202 22387215 32098872 details
TFE2_HUMANKAT2B_HUMANBioGRID, HPRD12435739 15507449 details
TFE2_HUMANCALM1_HUMANBioGRID, HPRD10757985 details
TFE2_HUMANCALM2_HUMANBioGRID, HPRD10757985 details
TFE2_HUMANCALM3_HUMANBioGRID, HPRD10757985 details
TFE2_HUMANLMX1A_HUMANBioGRID9199284 details
TFE2_HUMANMTG16_HUMANBioGRID16407974 26593974 details
TFE2_HUMANMYF5_HUMANBioGRID, HPRD2385294 9242638 details
TFE2_HUMANUBC9_HUMANBioGRID, HPRD10497239 details
TFE2_HUMANLYL1_HUMANBioGRID, HPRD8628307 details
TFE2_HUMANMAPK3_HUMANBioGRID, HPRD10781029 details
TFE2_HUMANDAXX_HUMANBioGRID19308989 details
TFE2_HUMANMEN1_HUMANBioGRID19074834 details
TFE2_HUMANTLE1_HUMANBioGRID18611861 24596249 details
TFE2_HUMANKAT2A_HUMANBioGRID23044487 28205554 details
TFE2_HUMANTRRAP_HUMANBioGRID23044487 details
TFE2_HUMANSUPT3_HUMANBioGRID23044487 details
TFE2_HUMANTAD2A_HUMANBioGRID23044487 details
TFE2_HUMANUSF1_HUMANBioGRID9050988 details
TFE2_HUMANSCX_HUMANBioGRID9050988 details
TFE2_HUMANTCF21_HUMANBioGRID, HPRD11591653 21771727 details
TFE2_HUMANMAPK2_HUMANBioGRID, HPRD10781029 details
TFE2_HUMANBHE40_HUMANBioGRID9050988 details
TFE2_HUMANPARP1_HUMANBioGRID9050988 details
TFE2_HUMANPSMD4_HUMANBioGRID, HPRD9235903 details
TFE2_HUMANCASL_HUMANBioGRID, HPRD10502414 details
TFE2_HUMANGLIS1_HUMANBioGRID28205554 details
TFE2_HUMANAURKA_HUMANBioGRID28205554 details
TFE2_HUMANDACH1_HUMANBioGRID28205554 details
TFE2_HUMANNSD3_HUMANBioGRID28205554 details
TFE2_HUMANMUSC_HUMANHPRD9584154 details
TFE2_HUMANFOXH1_HUMANbhf-ucl, BioGRID21828274 details
TFE2_HUMANHTF4_HUMANbhf-ucl, BioGRID, HPRD12566462 1446075 21828274 details
TFE2_HUMANFER3L_HUMANBioGRID, HPRD, IntAct12217327 28514442 details
TFE2_HUMANSKP2_HUMANBioGRID, HPRD14592976 15456869 details
TFE2_HUMANLDB1_HUMANBioGRID16407974 details
TFE2_HUMANELK3_HUMANBioGRID, HPRD8918463 details
TFE2_HUMANMTG8_HUMANBioGRID, HPRD15333839 details
TFE2_HUMANRUNX1_HUMANBioGRID15333839 28533407 details
TFE2_HUMANTRI33_HUMANBioGRID20603019 details
TFE2_HUMANIN80E_HUMANBioGRID17721549 details
TFE2_HUMANTYY1_HUMANBioGRID17721549 details
TFE2_HUMANRB_HUMANBioGRID10866689 details
TFE2_HUMANASB2_HUMANBioGRID21119685 details
TFE2_HUMANSOX2_HUMANBioGRID21532573 29383478 details
TFE2_HUMANBHA15_HUMANBioGRID, HPRD22354994 9073453 details
TFE2_HUMANRNF14_HUMANBioGRID23449499 details
TFE2_HUMANPTF1A_HUMANBioGRID18834332 details
TFE2_HUMANATOH1_HUMANBioGRID27542412 details
TFE2_HUMANOLIG1_HUMANBioGRID15280210 details
TFE2_HUMANOLIG2_HUMANBioGRID15280210 details
TFE2_HUMANCTNB1_HUMANHPRD12107263 15327769 details
TFE2_HUMANMDFI_HUMANHPRD11238923 details
TFE2_HUMANHXA1_HUMANHPRD9582372 details
TFE2_HUMANMK01_HUMANHPRD14592976 details
TFE2_HUMANTAL2_HUMANHPRD8152805 details
TFE2_HUMANSRF_HUMANHPRD8617811 details
TFE2_HUMANPDX1_HUMANHPRD10636926 details
TFE2_HUMANMK03_HUMANHPRD14592976 details
TFE2_HUMANLMX1B_HUMANHPRD9199284 details
TFE2_HUMANAEBP1_HUMANHPRD9624159 details
TFE2_HUMANTFPT_HUMANHPRD10086727 details
TFE2_HUMANRGPA1_HUMANHPRD12200424 details