Entity Details

Primary name TNNI3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19429
EntryNameTNNI3_HUMAN
FullNameTroponin I, cardiac muscle
TaxID9606
Evidenceevidence at protein level
Length210
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesTNNI3

GO terms

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GOName
GO:0001570 vasculogenesis
GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions
GO:0003009 skeletal muscle contraction
GO:0003779 actin binding
GO:0005829 cytosol
GO:0005861 troponin complex
GO:0006874 cellular calcium ion homeostasis
GO:0006936 muscle contraction
GO:0007507 heart development
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0019855 calcium channel inhibitor activity
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0030017 sarcomere
GO:0030049 muscle filament sliding
GO:0030172 troponin C binding
GO:0031014 troponin T binding
GO:0032780 negative regulation of ATPase activity
GO:0046872 metal ion binding
GO:0048306 calcium-dependent protein binding
GO:0051015 actin filament binding
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060047 heart contraction
GO:0060048 cardiac muscle contraction
GO:0097512 cardiac myofibril
GO:1990584 cardiac Troponin complex

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001978 TroponinFamilyFamily
IPR021666 Troponin I residues 1-32FamilyFamily
IPR038077 Troponin domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
115210 OMIMCardiomyopathy, familial restrictive 1 (RCM1)A heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function. The disease is caused by variants affecting the gene represented in this entry.
613690 OMIMCardiomyopathy, familial hypertrophic 7 (CMH7)A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. The disease is caused by variants affecting the gene represented in this entry.
611880 OMIMCardiomyopathy, dilated 2A (CMD2A)A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. The disease is caused by variants affecting the gene represented in this entry.
613286 OMIMCardiomyopathy, dilated 1FF (CMD1FF)A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB04513 N-(6-Aminohexyl)-5-Chloro-1-NaphthalenesulfonamideDrugbanksmall molecule

Interactions

26 interactions

InteractorPartnerSourcesPublicationsLink
TNNI3_HUMANTNNC1_HUMANBioGRID, HPRD, IntAct11904166 12060657 12122471 12840750 12939162 15049709 15134451 16302972 18986304 29997244 7957210 9346285 details
TNNI3_HUMANHGFL_HUMANBioGRID18986304 details
TNNI3_HUMANTNNT2_HUMANBioGRID, HPRD11904166 12840750 18986304 9219516 9560191 details
TNNI3_HUMANTNNC2_HUMANBioGRID, IntAct25416956 25910212 details
TNNI3_HUMANMYOME_HUMANIntAct21569246 details
TNNI3_HUMANRASFA_HUMANBioGRID, IntAct32296183 details
TNNI3_HUMANTRI63_HUMANBioGRID, MINT17426036 18157088 details
TNNI3_HUMANPK2L1_HUMANBioGRID, HPRD12809519 details
TNNI3_HUMANTNI3K_HUMANBioGRID, IntAct12721663 23369981 details
TNNI3_HUMANHSPB2_HUMANBioGRID26465331 details
TNNI3_HUMANSMUF2_HUMANMINT18157088 details
TNNI3_HUMANRCAN3_HUMANBioGRID, HPRD, IntAct16516408 details
TNNI3_HUMANPEX1_HUMANIntAct32814053 details
TNNI3_HUMANTRI55_HUMANBioGRID18157088 details
TNNI3_HUMANPRS8_HUMANBioGRID15604093 details
TNNI3_HUMANPKD2_HUMANBioGRID, HPRD12525172 details
TNNI3_HUMANRO52_HUMANIntAct11461834 details
TNNI3_HUMANWFS1_HUMANIntAct32814053 details
TNNI3_HUMANLYST_HUMANBioGRID11984006 details
TNNI3_HUMANCALM2_HUMANDIP20080536 details
TNNI3_HUMANSOX4_HUMANBioGRID25969425 details
TNNI3_HUMANKPCA_HUMANHPRD11121119 11904166 14596793 15134451 2584239 8798526 9346285 details
TNNI3_HUMANTNNT1_HUMANHPRD11904166 details
TNNI3_HUMANPAPP1_HUMANHPRD12626203 details
TNNI3_HUMANACTS_HUMANHPRD12383268 details
TNNI3_HUMANTNNI3_HUMANHPRD12060657 details