Entity Details

Primary name CAN3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20807
EntryNameCAN3_HUMAN
FullNameCalpain-3
TaxID9606
Evidenceevidence at protein level
Length821
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesCAPN3

GO terms

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GOName
GO:0003824 catalytic activity
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005622 intracellular anatomical structure
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0007517 muscle organ development
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0008307 structural constituent of muscle
GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration
GO:0014850 response to muscle activity
GO:0030016 myofibril
GO:0030018 Z disc
GO:0030163 protein catabolic process
GO:0030239 myofibril assembly
GO:0030315 T-tubule
GO:0031402 sodium ion binding
GO:0031432 titin binding
GO:0031648 protein destabilization
GO:0032991 protein-containing complex
GO:0033234 negative regulation of protein sumoylation
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045214 sarcomere organization
GO:0045661 regulation of myoblast differentiation
GO:0045862 positive regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046716 muscle cell cellular homeostasis
GO:0050790 regulation of catalytic activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051592 response to calcium ion
GO:0055103 ligase regulator activity
GO:0060090 molecular adaptor activity
GO:0061061 muscle structure development
GO:0065003 protein-containing complex assembly
GO:0070315 G1 to G0 transition involved in cell differentiation
GO:0071277 cellular response to calcium ion
GO:0071472 cellular response to salt stress
GO:0072657 protein localization to membrane
GO:0097264 self proteolysis
GO:1990092 calcium-dependent self proteolysis

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000169 Cysteine peptidase, cysteine active siteSiteActive site
IPR001300 Peptidase C2, calpain, catalytic domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR022682 Peptidase C2, calpain, large subunit, domain IIIDomainDomain
IPR022683 Peptidase C2, calpain, domain IIIDomainDomain
IPR022684 Peptidase C2, calpain familyFamilyFamily
IPR029531 Calpain-3FamilyFamily
IPR033883 Calpain subdomain IIIDomainDomain
IPR036213 Calpain large subunit, domain III superfamilyFamilyHomologous superfamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618129 OMIMMuscular dystrophy, limb-girdle, autosomal dominant 4 (LGMDD4)A form of autosomal dominant limb-girdle muscular dystrophy, a myopathy characterized by proximal and/or distal muscle weakness and atrophy. The age at onset is variable and can range from the first to the sixth decade, although later onset is less common. LGMDD4 is characterized by onset of proximal muscle weakness in young adulthood, gait difficulties, increased serum creatine kinase, myalgia, and back pain. Some patients may have upper limb involvement. Disease severity and expressivity are highly variable. The disease is caused by variants affecting the gene represented in this entry.
253600 OMIMMuscular dystrophy, limb-girdle, autosomal recessive 1 (LGMDR1)An autosomal recessive degenerative myopathy characterized by progressive symmetrical atrophy and weakness of the proximal limb muscles and elevated serum creatine kinase. The symptoms usually begin during the first two decades of life, and the disease gradually worsens, often resulting in loss of walking ability 10 or 20 years after onset. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB06124 L-aminocarnityl-succinyl-leucyl-argininal-diethylacetalDrugbanksmall molecule

Interactions

47 interactions

InteractorPartnerSourcesPublicationsLink
CAN3_HUMANTITIN_HUMANBioGRID, HPRD, IntAct, MINT10987085 20860623 23414517 8537379 9185618 9642272 9763216 details
CAN3_HUMANCRYAB_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANPOMP_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANC1T9A_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANAMOT_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANFND3B_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANCMYA5_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANMYBPH_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANMYPC1_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANMMP2_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANPRS6A_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANPPCEL_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANRN167_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANPSMD1_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANCAN3_HUMANBioGRID, HPRD, IntAct, MINT15073171 24846670 32296183 details
CAN3_HUMANNTAQ1_HUMANBioGRID, IntAct25416956 32296183 details
CAN3_HUMANOSGI1_HUMANBioGRID, IntAct25416956 31515488 details
CAN3_HUMANTFCP2_HUMANBioGRID, IntAct26871637 details
CAN3_HUMANEXOC8_HUMANBioGRID, IntAct32296183 details
CAN3_HUMANZN410_HUMANIntAct32296183 details
CAN3_HUMANVEZF1_HUMANIntAct32296183 details
CAN3_HUMANBYST_HUMANIntAct32296183 details
CAN3_HUMANECHP_HUMANIntAct32296183 details
CAN3_HUMANGTPB3_HUMANBioGRID, IntAct32296183 details
CAN3_HUMANC102B_HUMANBioGRID, IntAct32296183 details
CAN3_HUMANRUFY3_HUMANBioGRID, IntAct32296183 details
CAN3_HUMANKANK2_HUMANBioGRID, IntAct32296183 details
CAN3_HUMANMLP3C_HUMANBioGRID, IntAct32296183 details
CAN3_HUMANTRI63_HUMANBioGRID, IntAct31391242 details
CAN3_HUMANCASP6_HUMANIntAct32814053 details
CAN3_HUMANCLAT_HUMANIntAct32814053 details
CAN3_HUMANFGFR3_HUMANIntAct32814053 details
CAN3_HUMANGELS_HUMANIntAct32814053 details
CAN3_HUMANLAMP2_HUMANIntAct32814053 details
CAN3_HUMANRAN_HUMANIntAct32814053 details
CAN3_HUMANUBQL1_HUMANIntAct32814053 details
CAN3_HUMANSHLB1_HUMANIntAct32814053 details
CAN3_HUMANPR40A_HUMANIntAct32814053 details
CAN3_HUMANNECA2_HUMANBioGRID, HPRD16189514 details
CAN3_HUMANFLNC_HUMANBioGRID, HPRD14506720 details
CAN3_HUMANCEP76_HUMANBioGRID26871637 details
CAN3_HUMANTRI55_HUMANBioGRID31391242 details
CAN3_HUMANTRI54_HUMANIntAct31391242 details
CAN3_HUMANFXR1_HUMANMINT21653829 details
CAN3_HUMANUBE3A_HUMANMINT21653829 details
CAN3_HUMAN1433T_HUMANHPRD15324660 details
CAN3_HUMANDYSF_HUMANHPRD15827562 details