Entity Details

Primary name GATA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23769
EntryNameGATA2_HUMAN
FullNameEndothelial transcription factor GATA-2
TaxID9606
Evidenceevidence at protein level
Length480
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesGATA2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001655 urogenital system development
GO:0001709 cell fate determination
GO:0001764 neuron migration
GO:0001892 embryonic placenta development
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006909 phagocytosis
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007596 blood coagulation
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010725 regulation of primitive erythrocyte differentiation
GO:0021514 ventral spinal cord interneuron differentiation
GO:0021533 cell differentiation in hindbrain
GO:0021902 commitment of neuronal cell to specific neuron type in forebrain
GO:0021954 central nervous system neuron development
GO:0021983 pituitary gland development
GO:0033993 response to lipid
GO:0035019 somatic stem cell population maintenance
GO:0035065 regulation of histone acetylation
GO:0035854 eosinophil fate commitment
GO:0042472 inner ear morphogenesis
GO:0043306 positive regulation of mast cell degranulation
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045165 cell fate commitment
GO:0045599 negative regulation of fat cell differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045650 negative regulation of macrophage differentiation
GO:0045654 positive regulation of megakaryocyte differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048469 cell maturation
GO:0048873 homeostasis of number of cells within a tissue
GO:0050766 positive regulation of phagocytosis
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0060216 definitive hemopoiesis
GO:0060872 semicircular canal development
GO:0061042 vascular wound healing
GO:0070345 negative regulation of fat cell proliferation
GO:0070742 C2H2 zinc finger domain binding
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090102 cochlea development
GO:0097154 GABAergic neuron differentiation
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000178 negative regulation of neural precursor cell proliferation
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2000977 regulation of forebrain neuron differentiation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000679 Zinc finger, GATA-typeDomainDomain
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR016374 Transcription factor, GATA-2/3FamilyFamily
IPR029522 Transcription factor GATA-2FamilyFamily
IPR039355 Transcription factor GATAFamilyFamily

Diseases

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Disease IDSourceNameDescription
614286 OMIMMyelodysplastic syndrome (MDS)A heterogeneous group of closely related clonal hematopoietic disorders. All are characterized by a hypercellular or hypocellular bone marrow with impaired morphology and maturation, dysplasia of the myeloid, megakaryocytic and/or erythroid lineages, and peripheral blood cytopenias resulting from ineffective blood cell production. Included diseases are: refractory anemia (RA), refractory anemia with ringed sideroblasts (RARS), refractory anemia with excess blasts (RAEB), refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD-RS); chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative disease. MDS is considered a premalignant condition in a subgroup of patients that often progresses to acute myeloid leukemia (AML). The disease is caused by variants affecting the gene represented in this entry.
614172 OMIMImmunodeficiency 21 (IMD21)An immunodeficiency disease characterized by profoundly decreased or absent monocytes, B-lymphocytes, natural killer lymphocytes, and circulating and tissue dendritic cells, with little or no effect on T-cell numbers. Clinical features of DCML include susceptibility to disseminated non-tuberculous mycobacterial infections, papillomavirus infections, opportunistic fungal infections, and pulmonary alveolar proteinosis. Bone marrow hypocellularity and dysplasia of myeloid, erythroid, and megakaryocytic lineages are present in most patients, as are karyotypic abnormalities, including monosomy 7 and trisomy 8. This syndrome links susceptibility to mycobacterial, viral, and fungal infections with malignancy and can be transmitted in an autosomal dominant pattern. The disease is caused by variants affecting the gene represented in this entry.
614038 OMIMLymphedema, primary, with myelodysplasia (LMPM)A chronic disabling condition characterized by swelling of the extremities due to altered lymphatic flow, associated with myelodysplasia. Patients with lymphedema suffer from recurrent local infections, and physical impairment. The disease is caused by variants affecting the gene represented in this entry.

Interactions

65 interactions

InteractorPartnerSourcesPublicationsLink
GATA2_HUMANTAL1_HUMANBioGRID, IntAct7568177 details
GATA2_HUMANSMAD4_HUMANBioGRID, IntAct20211142 21988832 details
GATA2_HUMANPSA3_HUMANBioGRID, IntAct25416956 31515488 details
GATA2_HUMANTRI23_HUMANBioGRID, IntAct25416956 31515488 details
GATA2_HUMANKR109_HUMANBioGRID, IntAct25416956 details
GATA2_HUMANPR20C_HUMANBioGRID, IntAct25416956 details
GATA2_HUMANGOGA2_HUMANBioGRID, IntAct25416956 31515488 details
GATA2_HUMANTRAF1_HUMANBioGRID, IntAct25416956 details
GATA2_HUMANFHL3_HUMANBioGRID, IntAct25416956 31515488 details
GATA2_HUMANK1C40_HUMANBioGRID, IntAct25416956 details
GATA2_HUMANATL4_HUMANBioGRID, IntAct25416956 details
GATA2_HUMANNT2NA_HUMANBioGRID, IntAct25416956 31515488 details
GATA2_HUMANMDFI_HUMANBioGRID, IntAct25416956 31515488 details
GATA2_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
GATA2_HUMANRBPMS_HUMANBioGRID, IntAct32296183 details
GATA2_HUMANKRA71_HUMANBioGRID, IntAct32296183 details
GATA2_HUMANKR133_HUMANBioGRID, IntAct32296183 details
GATA2_HUMANMSX2_HUMANBioGRID, IntAct32296183 details
GATA2_HUMANKRA31_HUMANBioGRID, IntAct32296183 details
GATA2_HUMANKRA81_HUMANBioGRID, IntAct32296183 details
GATA2_HUMANKR111_HUMANBioGRID, IntAct32296183 details
GATA2_HUMANKR212_HUMANBioGRID, IntAct32296183 details
GATA2_HUMANHDAC1_HUMANDIP18250304 details
GATA2_HUMANCBP_HUMANDIP18250304 details
GATA2_HUMANSPI1_HUMANBioGRID, DIP, HPRD10364157 10411939 18250304 details
GATA2_HUMANCLAT_HUMANIntAct32814053 details
GATA2_HUMANFGFR3_HUMANIntAct32814053 details
GATA2_HUMANGRN_HUMANIntAct32814053 details
GATA2_HUMANWFS1_HUMANIntAct32814053 details
GATA2_HUMANRNF11_HUMANIntAct32814053 details
GATA2_HUMANZBT32_HUMANBioGRID, HPRD, IntAct11964310 20211142 details
GATA2_HUMANOBF1_HUMANBioGRID, IntAct20211142 details
GATA2_HUMANPML_HUMANBioGRID, HPRD10938104 details
GATA2_HUMANHDAC3_HUMANBioGRID, HPRD11567998 details
GATA2_HUMANPIT1_HUMANBioGRID, HPRD10367888 16396960 details
GATA2_HUMANZBT16_HUMANBioGRID, HPRD11964310 details
GATA2_HUMANRBTN2_HUMANBioGRID7568177 details
GATA2_HUMANJUN_HUMANBioGRID, HPRD11278891 details
GATA2_HUMANMED1_HUMANBioGRID16396960 details
GATA2_HUMANEP300_HUMANBioGRID15001660 details
GATA2_HUMANKAT2A_HUMANBioGRID15001660 details
GATA2_HUMANAKT1_HUMANBioGRID, HPRD15837948 details
GATA2_HUMANPR20E_HUMANBioGRID25416956 details
GATA2_HUMANPR20D_HUMANBioGRID25416956 details
GATA2_HUMANPR20B_HUMANBioGRID25416956 details
GATA2_HUMANPR20A_HUMANBioGRID25416956 details
GATA2_HUMANKR103_HUMANBioGRID25416956 details
GATA2_HUMANNT2NC_HUMANBioGRID25416956 details
GATA2_HUMANFBXW7_HUMANBioGRID25670854 details
GATA2_HUMANCDK1_HUMANBioGRID25670854 details
GATA2_HUMANRARA_HUMANHPRD15254248 details
GATA2_HUMANFOG1_HUMANBioGRID, HPRD, IntAct12483298 28514442 details
GATA2_HUMANCOT2_HUMANDIP18250317 details
GATA2_HUMANHDAC5_HUMANBioGRID, HPRD11567998 details
GATA2_HUMANSKP1_HUMANBioGRID25670854 details
GATA2_HUMANCUL1_HUMANBioGRID25670854 details
GATA2_HUMANRBX1_HUMANBioGRID25670854 details
GATA2_HUMANCCNA2_HUMANBioGRID17255359 details
GATA2_HUMANCDK2_HUMANBioGRID17255359 details
GATA2_HUMANCDK4_HUMANBioGRID17255359 details
GATA2_HUMANCEBPA_HUMANHPRD1563207 details
GATA2_HUMANSTAT3_HUMANHPRD15673499 details
GATA2_HUMANMK01_HUMANHPRD7876160 details
GATA2_HUMANHHEX_HUMANHPRD15016828 details
GATA2_HUMANRXRA_HUMANHPRD15254248 details