Entity Details

Primary name MARK3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP27448
EntryNameMARK3_HUMAN
FullNameMAP/microtubule affinity-regulating kinase 3
TaxID9606
Evidenceevidence at protein level
Length753
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesMARK3

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000226 microtubule cytoskeleton organization
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0030425 dendrite
GO:0032092 positive regulation of protein binding
GO:0035331 negative regulation of hippo signaling
GO:0035556 intracellular signal transduction
GO:0036289 peptidyl-serine autophosphorylation
GO:0048156 tau protein binding
GO:0050321 tau-protein kinase activity
GO:0070062 extracellular exosome
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001772 Kinase associated domain 1 (KA1)DomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015940 Ubiquitin-associated domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR028375 KA1 domain/Ssp2, C-terminalFamilyHomologous superfamily
IPR033628 Serine/threonine-protein kinase MARK3FamilyFamily

Diseases

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Disease IDSourceNameDescription
618283 OMIMVisual impairment and progressive phthisis bulbi (VIPB)An autosomal recessive, progressive disease characterized by poor vision at birth and development of bilateral phthisis bulbi by adulthood. The disease may be caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

44 interactions

InteractorPartnerSourcesPublicationsLink
MARK3_HUMANCLAP2_HUMANBioGRID29089450 details
MARK3_HUMANNOL11_HUMANHPRD, IntAct16169070 details
MARK3_HUMANPLPL2_HUMANBioGRID, HPRD, IntAct16169070 details
MARK3_HUMAN1433S_HUMANBioGRID, HPRD, IntAct, MINT15778465 16189514 details
MARK3_HUMAN1433T_HUMANBioGRID, IntAct15161933 17353931 20642453 28514442 29089450 details
MARK3_HUMANTAU_HUMANBioGRID, IntAct23666762 details
MARK3_HUMAN1433Z_HUMANBioGRID, HPRD, IntAct, MINT14676191 15161933 16306228 16959763 16968750 20642453 25852190 26496610 28514442 29089450 details
MARK3_HUMANVATL_HUMANBioGRID, HPRD, IntAct16169070 details
MARK3_HUMANVPS11_HUMANBioGRID, HPRD, IntAct16169070 details
MARK3_HUMANCPSF4_HUMANHPRD, IntAct16169070 details
MARK3_HUMANFBX7_HUMANBioGRID27503909 details
MARK3_HUMANTTHY_HUMANBioGRID, HPRD, IntAct16169070 details
MARK3_HUMANMPPB_HUMANBioGRID, HPRD, IntAct16169070 details
MARK3_HUMANMPIP3_HUMANBioGRID, HPRD10557092 11333986 11551930 12941695 15319445 16968750 9278512 9543386 details
MARK3_HUMANMARK3_HUMANBioGRID15319445 18082144 29089450 details
MARK3_HUMANSCG1_HUMANBioGRID, HPRD, IntAct16169070 details
MARK3_HUMANPIM1_HUMANBioGRID, IntAct15319445 26186194 28514442 details
MARK3_HUMANSAAL1_HUMANBioGRID, HPRD, IntAct16169070 details
MARK3_HUMANKSR1_HUMANBioGRID, HPRD11741534 12941695 29089450 details
MARK3_HUMANTCEA2_HUMANBioGRID, HPRD, IntAct16169070 details
MARK3_HUMANASB13_HUMANBioGRID, HPRD, IntAct16169070 details
MARK3_HUMANPKP2_HUMANBioGRID, HPRD, MINT12941695 details
MARK3_HUMANCLAP1_HUMANBioGRID29089450 details
MARK3_HUMANHDAC7_HUMANBioGRID16980613 details
MARK3_HUMANFANCF_HUMANHPRD, IntAct16169070 details
MARK3_HUMANMTAP2_HUMANBioGRID12879020 details
MARK3_HUMANMITF_HUMANBioGRID20058232 details
MARK3_HUMANRGRF1_HUMANBioGRID9543386 details
MARK3_HUMANARHG2_HUMANBioGRID29089450 details
MARK3_HUMANIKKB_HUMANMINT17363905 details
MARK3_HUMAN1433G_HUMANBioGRID, HPRD, IntAct, MINT15324660 16959763 17353931 20642453 28514442 29089450 details
MARK3_HUMAN1433E_HUMANBioGRID, IntAct16306228 16968750 17979178 20642453 29089450 details
MARK3_HUMANAAPK1_HUMANBioGRID16306228 details
MARK3_HUMAN1433B_HUMANBioGRID, IntAct, MINT15324660 16959763 17353931 20642453 24255178 28514442 29089450 details
MARK3_HUMAN1433F_HUMANBioGRID, IntAct14676191 16959763 17979178 20642453 28514442 29089450 details
MARK3_HUMANUBP21_HUMANBioGRID, IntAct19615732 22298430 details
MARK3_HUMANHDAC5_HUMANBioGRID16980613 details
MARK3_HUMANPPM1B_HUMANMINT12556533 details
MARK3_HUMANDYL1_HUMANHPRD14760703 details
MARK3_HUMANKPCT_HUMANHPRD, MINT17363905 8816492 details
MARK3_HUMANFOS_HUMANIntAct20195357 details
MARK3_HUMANANKR7_HUMANIntAct16169070 details
MARK3_HUMANTERF2_HUMANBioGRID20811636 details
MARK3_HUMANHDAC4_HUMANBioGRID16980613 details