Entity Details

Primary name NOS3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29474
EntryNameNOS3_HUMAN
FullNameNitric oxide synthase, endothelial
TaxID9606
Evidenceevidence at protein level
Length1203
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesNOS3

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001974 blood vessel remodeling
GO:0003100 regulation of systemic arterial blood pressure by endothelin
GO:0003180 aortic valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003785 actin monomer binding
GO:0004517 nitric-oxide synthase activity
GO:0005516 calmodulin binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0006527 arginine catabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0007005 mitochondrion organization
GO:0007263 nitric oxide mediated signal transduction
GO:0008217 regulation of blood pressure
GO:0008285 negative regulation of cell population proliferation
GO:0009408 response to heat
GO:0009725 response to hormone
GO:0010181 FMN binding
GO:0010544 negative regulation of platelet activation
GO:0010628 positive regulation of gene expression
GO:0012506 vesicle membrane
GO:0014740 negative regulation of muscle hyperplasia
GO:0014806 smooth muscle hyperplasia
GO:0016491 oxidoreductase activity
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0019430 removal of superoxide radicals
GO:0020037 heme binding
GO:0030666 endocytic vesicle membrane
GO:0031284 positive regulation of guanylate cyclase activity
GO:0031644 regulation of nervous system process
GO:0032496 response to lipopolysaccharide
GO:0034405 response to fluid shear stress
GO:0034617 tetrahydrobiopterin binding
GO:0034618 arginine binding
GO:0042311 vasodilation
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043542 endothelial cell migration
GO:0045454 cell redox homeostasis
GO:0045747 positive regulation of Notch signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0045776 negative regulation of blood pressure
GO:0046146 tetrahydrobiopterin metabolic process
GO:0046870 cadmium ion binding
GO:0048873 homeostasis of number of cells within a tissue
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
GO:0050999 regulation of nitric-oxide synthase activity
GO:0070168 negative regulation of biomineral tissue development
GO:0097746 blood vessel diameter maintenance
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Golgi apparatus
Membrane

Domains

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DomainNameCategoryType
IPR001094 Flavodoxin-likeDomainDomain
IPR001433 Oxidoreductase FAD/NAD(P)-bindingDomainDomain
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductaseDomainDomain
IPR003097 Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-bindingDomainDomain
IPR004030 Nitric oxide synthase, N-terminalDomainDomain
IPR008254 Flavodoxin/nitric oxide synthaseDomainDomain
IPR012144 Nitric-oxide synthase, eukaryoteFamilyFamily
IPR017927 FAD-binding domain, ferredoxin reductase-typeDomainDomain
IPR017938 Riboflavin synthase-like beta-barrelFamilyHomologous superfamily
IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamilyFamilyHomologous superfamily
IPR029039 Flavoprotein-like superfamilyFamilyHomologous superfamily
IPR036119 Nitric oxide synthase, N-terminal domain superfamilyFamilyHomologous superfamily
IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00125 ArginineDrugbanksmall molecule
DB00155 CitrullineDrugbanksmall molecule
DB00360 SapropterinDrugbanksmall molecule
DB00997 DoxorubicinDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB01686 N,N-dimethylarginineDrugbanksmall molecule
DB01821 L-N(omega)-Nitroarginine-2,4-L-diaminobutyric amideDrugbanksmall molecule
DB01833 CanavanineDrugbanksmall molecule
DB01997 3-Bromo-7-NitroindazoleDrugbanksmall molecule
DB02027 N-{(4S)-4-Amino-5-[(2-aminoethyl)amino]pentyl}-N'-nitroguanidineDrugbanksmall molecule
DB02044 N-[3-(aminomethyl)benzyl]acetamidineDrugbanksmall molecule
DB02048 1,2,4-Triazole-CarboxamidineDrugbanksmall molecule
DB02077 L-N(omega)-nitroarginine-(4R)-amino-L-proline amideDrugbanksmall molecule
DB02141 S,S'-(1,4-Phenylene-Bis(1,2-Ethanediyl))Bis-IsothioureaDrugbanksmall molecule
DB02207 7-NitroindazoleDrugbanksmall molecule
DB02234 S-EthylisothioureaDrugbanksmall molecule
DB02335 2-AminothiazolineDrugbanksmall molecule
DB02589 Se-Ethyl-IsoselenoureaDrugbanksmall molecule
DB02911 2,4-Diamino-6-Phenyl-5,6,7,8,-TetrahydropteridineDrugbanksmall molecule
DB02979 N1,N14-Bis((S-Methyl)Isothioureido)TetradecaneDrugbanksmall molecule
DB02994 Cacodylic acidDrugbanksmall molecule
DB03065 7-Nitroindazole-2-CarboxamidineDrugbanksmall molecule
DB03100 6-NitroindazoleDrugbanksmall molecule
DB03144 N(5)-[(hydroxyamino)(imino)methyl]-L-ornithineDrugbanksmall molecule
DB03305 N(G)-IminoethylornithineDrugbanksmall molecule
DB03332 5,6-Cyclic-TetrahydropteridineDrugbanksmall molecule
DB03707 S-Ethyl-N-Phenyl-IsothioureaDrugbanksmall molecule
DB03910 S,S'-(1,3-Phenylene-Bis(1,2-Ethanediyl))Bis-IsothioureaDrugbanksmall molecule
DB03918 6S-5,6,7,8-TetrahydrobiopterinDrugbanksmall molecule
DB03963 S-(Dimethylarsenic)CysteineDrugbanksmall molecule
DB03974 L-homoarginineDrugbanksmall molecule
DB04018 S-Isopropyl-IsothioureaDrugbanksmall molecule
DB04223 NitroarginineDrugbanksmall molecule
DB04534 5-NitroindazoleDrugbanksmall molecule
DB04559 N-(Chlorophenyl)-N'-hydroxyguanidineDrugbanksmall molecule
DB06154 Pentaerythritol tetranitrateDrugbanksmall molecule
DB07001 (3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imineDrugbanksmall molecule
DB07244 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINEDrugbanksmall molecule
DB07388 ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATEDrugbanksmall molecule
DB08018 N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINEDrugbanksmall molecule
DB08019 N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamineDrugbanksmall molecule
DB09237 LevamlodipineDrugbanksmall molecule

Interactions

100 interactions

InteractorPartnerSourcesPublicationsLink
NOS3_HUMANNOSTN_HUMANBioGRID, HPRD, MINT, UniProt12446846 16234328 details
NOS3_HUMANCALM2_HUMANBioGRID, IntAct11397791 19358819 20705923 22486744 9115269 details
NOS3_HUMANCDC37_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANGCDH_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANF10A1_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANFIS1_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANFBLN3_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANFBLN4_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANACTN2_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANTXD11_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANHTRA1_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANMPRIP_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANMIC60_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANRNF31_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANUMPS_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANACTN4_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANH33_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANA2MG_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANEXOC6_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANMAST1_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANELAV3_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANRNF32_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANKANK2_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANELAV1_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANP4K2A_HUMANBioGRID, IntAct21163940 details
NOS3_HUMANAKT1_HUMANBioGRID, HPRD, IntAct10376603 11425855 11696579 23397142 25241761 details
NOS3_HUMANMAGAB_HUMANBioGRID, IntAct25416956 details
NOS3_HUMANGOGA2_HUMANBioGRID, IntAct25416956 32296183 details
NOS3_HUMANIKZF3_HUMANBioGRID, IntAct32296183 details
NOS3_HUMANACTB_HUMANBioGRID, DIP17502619 details
NOS3_HUMANHBA_HUMANDIP23123858 details
NOS3_HUMANZN232_HUMANIntAct32814053 details
NOS3_HUMANNHRF3_HUMANIntAct32814053 details
NOS3_HUMANNVL_HUMANIntAct32814053 details
NOS3_HUMANKT33B_HUMANIntAct32814053 details
NOS3_HUMANHNRPK_HUMANIntAct32814053 details
NOS3_HUMANFANCG_HUMANIntAct32814053 details
NOS3_HUMANAP2B1_HUMANIntAct32814053 details
NOS3_HUMANNSMF_HUMANIntAct32814053 details
NOS3_HUMANST4A1_HUMANIntAct32814053 details
NOS3_HUMANMICA2_HUMANIntAct32814053 details
NOS3_HUMANPCSK7_HUMANIntAct32814053 details
NOS3_HUMANHYAL2_HUMANIntAct32814053 details
NOS3_HUMANCSN3_HUMANIntAct32814053 details
NOS3_HUMANTRI69_HUMANIntAct32814053 details
NOS3_HUMANRN183_HUMANIntAct32814053 details
NOS3_HUMANCF141_HUMANIntAct32814053 details
NOS3_HUMANPPR21_HUMANIntAct32814053 details
NOS3_HUMANH32_HUMANIntAct32814053 details
NOS3_HUMANSPA2L_HUMANIntAct32814053 details
NOS3_HUMANPP16A_HUMANIntAct32814053 details
NOS3_HUMANMPND_HUMANIntAct32814053 details
NOS3_HUMANWDR61_HUMANIntAct32814053 details
NOS3_HUMANREXO4_HUMANIntAct32814053 details
NOS3_HUMANARFG1_HUMANIntAct32814053 details
NOS3_HUMANASIC4_HUMANIntAct32814053 details
NOS3_HUMANPCMD2_HUMANIntAct32814053 details
NOS3_HUMANTHAP1_HUMANIntAct32814053 details
NOS3_HUMANRBM11_HUMANIntAct32814053 details
NOS3_HUMANWWOX_HUMANIntAct32814053 details
NOS3_HUMANCRLF3_HUMANIntAct32814053 details
NOS3_HUMANASB3_HUMANIntAct32814053 details
NOS3_HUMANUBQL3_HUMANIntAct32814053 details
NOS3_HUMANKLH20_HUMANIntAct32814053 details
NOS3_HUMANPIAS1_HUMANIntAct32814053 details
NOS3_HUMANLEG9C_HUMANIntAct32814053 details
NOS3_HUMANVSX2_HUMANIntAct32814053 details
NOS3_HUMANSPRE2_HUMANIntAct32814053 details
NOS3_HUMANSPRE1_HUMANIntAct32814053 details
NOS3_HUMANMET27_HUMANIntAct32814053 details
NOS3_HUMANSAMD3_HUMANIntAct32814053 details
NOS3_HUMANHS90A_HUMANBioGRID, HPRD11425855 11744239 11988487 12124224 12676772 details
NOS3_HUMANGCYB1_HUMANBioGRID12676772 details
NOS3_HUMANCALM1_HUMANBioGRID11397791 19358819 20705923 22486744 9115269 details
NOS3_HUMANCALM3_HUMANBioGRID11397791 19358819 20705923 22486744 9115269 details
NOS3_HUMANNOSIP_HUMANBioGRID, HPRD11149895 16135813 details
NOS3_HUMANNOS3_HUMANBioGRID, HPRD10074942 11149895 12176133 12437348 15721862 18849972 8995432 9115269 9516116 details
NOS3_HUMANA4_HUMANBioGRID21163940 details
NOS3_HUMANAPOE_HUMANBioGRID21163940 details
NOS3_HUMANCEP55_HUMANBioGRID21163940 details
NOS3_HUMANEXOS1_HUMANBioGRID21163940 details
NOS3_HUMANPAXI1_HUMANBioGRID21163940 details
NOS3_HUMANPSN2_HUMANBioGRID21163940 details
NOS3_HUMANPSN1_HUMANBioGRID21163940 details
NOS3_HUMANTECR_HUMANBioGRID21163940 details
NOS3_HUMANCTNB1_HUMANIntAct25062958 details
NOS3_HUMANDYN1_HUMANDIP16432212 details
NOS3_HUMANCAV1_HUMANBioGRID, DIP, HPRD11425855 12852865 17502619 8910295 details
NOS3_HUMANSIR1_HUMANBioGRID, DIP20479254 details
NOS3_HUMANHDAC3_HUMANBioGRID20705923 details
NOS3_HUMANKCC2A_HUMANBioGRID11397791 details
NOS3_HUMANPTPA_HUMANBioGRID28760745 details
NOS3_HUMANKEAP1_HUMANBioGRID31491600 details
NOS3_HUMANBKRB2_HUMANHPRD10510297 10681501 details
NOS3_HUMANBDNF_HUMANHPRD10493752 details
NOS3_HUMANNMT1_HUMANHPRD7512951 details
NOS3_HUMANSP1_HUMANHPRD7541039 details
NOS3_HUMAN2A5A_HUMANHPRD11397791 12501214 details
NOS3_HUMANEDNRB_HUMANHPRD10510297 details
NOS3_HUMANAGTR1_HUMANHPRD10510297 details