Entity Details

Primary name MCM4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP33991
EntryNameMCM4_HUMAN
FullNameDNA replication licensing factor MCM4
TaxID9606
Evidenceevidence at protein level
Length863
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesMCM4

GO terms

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GOName
GO:0000727 double-strand break repair via break-induced replication
GO:0000781 chromosome, telomeric region
GO:0003678 DNA helicase activity
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0016020 membrane
GO:0016787 hydrolase activity
GO:0036388 pre-replicative complex assembly
GO:0042555 MCM complex
GO:0071162 CMG complex
GO:1902975 mitotic DNA replication initiation

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR001208 MCM domainDomainDomain
IPR008047 Mini-chromosome maintenance complex protein 4FamilyFamily
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR018525 Mini-chromosome maintenance, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR027925 MCM N-terminal domainDomainDomain
IPR031327 Mini-chromosome maintenance proteinFamilyFamily
IPR033762 MCM OB domainDomainDomain
IPR041562 MCM, AAA-lid domainDomainDomain

Diseases

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Disease IDSourceNameDescription
609981 OMIMImmunodeficiency 54 (IMD54)An autosomal recessive disorder characterized by severe intra- and extrauterine growth retardation, microcephaly, decreased numbers of natural killer cells, and recurrent viral infections, most often affecting the respiratory tract and leading to respiratory failure. Affected individuals also have adrenal insufficiency requiring corticosteroid replacement therapy and may have an increased susceptibility to cancer. The disease is caused by variants affecting the gene represented in this entry.

Interactions

67 interactions

InteractorPartnerSourcesPublicationsLink
MCM4_HUMANORC6_HUMANBioGRID, HPRD, IntAct12614612 15232106 details
MCM4_HUMANCDC5L_HUMANBioGRID, HPRD, IntAct15232106 details
MCM4_HUMANMCM7_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10567526 10748114 12207017 12364596 12614612 12694531 15232106 17296731 22540012 22863883 22939629 23764002 24299456 26344197 27173435 7601140 8631321 8798650 9099751 unassigned1312 details
MCM4_HUMANCCNA1_HUMANBioGRID, HPRD, IntAct15232106 16519687 details
MCM4_HUMANMCM6_HUMANBioGRID, HPRD, IntAct, UniProt12207017 12364596 12614612 12694531 16902406 17296731 22863883 22939629 26344197 26496610 27173435 8798650 unassigned1312 details
MCM4_HUMANORC2_HUMANBioGRID, HPRD, IntAct12364596 12614612 details
MCM4_HUMANSSRP1_HUMANBioGRID, HPRD, IntAct, MINT16902406 21055985 28514442 details
MCM4_HUMANSP16H_HUMANBioGRID, HPRD, MINT16902406 details
MCM4_HUMANEP300_HUMANBioGRID, MINT20808282 30110629 details
MCM4_HUMANMCM2_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10567526 12614612 12694531 16899510 16902406 17296731 22540012 22863883 22939629 23764002 25963833 26344197 27173435 8798650 unassigned1312 details
MCM4_HUMANMCMBP_HUMANBioGRID, IntAct, MINT, UniProt17296731 22540012 24299456 25036637 details
MCM4_HUMANMCM3_HUMANBioGRID, HPRD, IntAct12614612 16902406 22939629 23764002 26344197 27621311 28514442 30108253 details
MCM4_HUMANTLX2_HUMANBioGRID, IntAct20211142 details
MCM4_HUMANCDC7_HUMANBioGRID, HPRD10846177 12614612 22540012 details
MCM4_HUMANMCM4_HUMANBioGRID, HPRD12614612 15236977 16902406 details
MCM4_HUMANORC1_HUMANBioGRID12614612 details
MCM4_HUMANORC3_HUMANBioGRID12614612 details
MCM4_HUMANORC4_HUMANBioGRID12614612 details
MCM4_HUMANORC5_HUMANBioGRID12614612 details
MCM4_HUMANDBF4A_HUMANBioGRID10846177 12614612 22540012 details
MCM4_HUMANRFA1_HUMANBioGRID12614612 details
MCM4_HUMANRFA2_HUMANBioGRID12614612 20679368 details
MCM4_HUMANCDK2_HUMANBioGRID, HPRD10748114 16517729 16519687 details
MCM4_HUMANCDT1_HUMANBioGRID18162579 details
MCM4_HUMANDNLI4_HUMANBioGRID22990118 details
MCM4_HUMANESCO2_HUMANBioGRID30100344 details
MCM4_HUMANSUMO2_HUMANBioGRID32786267 details
MCM4_HUMANCRCM_HUMANIntAct17353931 details
MCM4_HUMANGSTK1_HUMANIntAct17353931 details
MCM4_HUMANTONSL_HUMANBioGRID, MINT21055985 21113133 details
MCM4_HUMANPLK1_HUMANBioGRID, IntAct15654075 27173435 31730000 unassigned1312 details
MCM4_HUMANSBNO1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANWEE1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANBCR_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANJIP4_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANCD11A_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANTF3C4_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANPP4R2_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANEP15R_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANATG2B_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANTF3C2_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANHSF1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANSOX4_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANANK3_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANGAPD1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANSMC1A_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANSF3A1_HUMANBioGRID, IntAct22939629 26344197 27173435 unassigned1312 details
MCM4_HUMANP4R3A_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANRELCH_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANSMC3_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANUBP15_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANNS1BP_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM4_HUMANASF1A_HUMANBioGRID, IntAct22407294 28514442 details
MCM4_HUMANZN451_HUMANDIP26524493 details
MCM4_HUMANMCM8_HUMANBioGRID, HPRD12771218 details
MCM4_HUMANMCM5_HUMANBioGRID11248027 22939629 26344197 details
MCM4_HUMANING5_HUMANBioGRID16387653 details
MCM4_HUMANCDC45_HUMANBioGRID16902406 details
MCM4_HUMANEMD_HUMANBioGRID17620012 details
MCM4_HUMANHDAC5_HUMANBioGRID21081666 details
MCM4_HUMANMMS22_HUMANBioGRID21055985 details
MCM4_HUMANE2F3_HUMANBioGRID22157815 details
MCM4_HUMANRN126_HUMANBioGRID26508657 details
MCM4_HUMANFACD2_HUMANBioGRID23993743 24658369 details
MCM4_HUMANRECQ4_HUMANBioGRID19696745 29229926 details
MCM4_HUMANCHK1_HUMANBioGRID25049228 details
MCM4_HUMANCDK1_HUMANHPRD16519687 details