Entity Details

Primary name MCM5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP33992
EntryNameMCM5_HUMAN
FullNameDNA replication licensing factor MCM5
TaxID9606
Evidenceevidence at protein level
Length734
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesMCM5

GO terms

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GOName
GO:0000727 double-strand break repair via break-induced replication
GO:0000781 chromosome, telomeric region
GO:0003678 DNA helicase activity
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006270 DNA replication initiation
GO:0016020 membrane
GO:0016787 hydrolase activity
GO:0036388 pre-replicative complex assembly
GO:0042555 MCM complex
GO:0071162 CMG complex

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001208 MCM domainDomainDomain
IPR008048 DNA replication licensing factor Mcm5FamilyFamily
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR018525 Mini-chromosome maintenance, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR027925 MCM N-terminal domainDomainDomain
IPR031327 Mini-chromosome maintenance proteinFamilyFamily
IPR033762 MCM OB domainDomainDomain
IPR041562 MCM, AAA-lid domainDomainDomain

Diseases

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Disease IDSourceNameDescription
617564 OMIMMeier-Gorlin syndrome 8 (MGORS8)A form of Meier-Gorlin syndrome, a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. MGORS8 inheritance is autosomal recessive. The disease is caused by variants affecting the gene represented in this entry.

Interactions

66 interactions

InteractorPartnerSourcesPublicationsLink
MCM5_HUMANORC1_HUMANBioGRID, HPRD, IntAct15232106 details
MCM5_HUMANMCM3_HUMANBioGRID, HPRD, IntAct, MINT11248027 12364596 12614612 15232106 22540012 22863883 22939629 23993743 25843623 25963833 26264872 26344197 27621311 28514442 30108253 details
MCM5_HUMANMCM2_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11248027 12614612 15232106 16899510 17296731 22540012 22939629 23993743 24207054 25963833 26344197 details
MCM5_HUMANORC3_HUMANHPRD, IntAct15232106 details
MCM5_HUMANORC5_HUMANBioGRID, HPRD, IntAct15232106 details
MCM5_HUMANMCM7_HUMANBioGRID, HPRD, IntAct11248027 12614612 15232106 22939629 23764002 23993743 26344197 9099751 details
MCM5_HUMANCDN2A_HUMANBioGRID, IntAct15232106 details
MCM5_HUMANMDFI_HUMANBioGRID, HPRD, IntAct16189514 details
MCM5_HUMANEP300_HUMANBioGRID, MINT20808282 30110629 details
MCM5_HUMANMCMBP_HUMANBioGRID, IntAct, MINT, UniProt17296731 22540012 24299456 25036637 26344197 details
MCM5_HUMANNUDT3_HUMANBioGRID, MINT21900206 details
MCM5_HUMANCDC7_HUMANBioGRID, HPRD12614612 details
MCM5_HUMANORC2_HUMANBioGRID, HPRD12614612 26344197 details
MCM5_HUMANORC6_HUMANBioGRID, HPRD12614612 details
MCM5_HUMANRFA2_HUMANBioGRID, HPRD12614612 20679368 details
MCM5_HUMANSTAT1_HUMANBioGRID, HPRD11248027 9843502 details
MCM5_HUMANA4_HUMANBioGRID21832049 details
MCM5_HUMANCDC5L_HUMANBioGRID, HPRD15232106 20467437 details
MCM5_HUMANARF_HUMANBioGRID, HPRD15232106 details
MCM5_HUMANRBPMS_HUMANBioGRID25416956 details
MCM5_HUMANKR107_HUMANBioGRID25416956 details
MCM5_HUMANLMNA_HUMANBioGRID24623722 25963833 details
MCM5_HUMANMCPH1_HUMANBioGRID29150431 details
MCM5_HUMANFBX7_HUMANBioGRID27503909 details
MCM5_HUMANESCO2_HUMANBioGRID30100344 details
MCM5_HUMANPHB_HUMANBioGRID19377303 27025967 details
MCM5_HUMANTIF1B_HUMANBioGRID29955894 details
MCM5_HUMANPTEN_HUMANBioGRID31685992 details
MCM5_HUMANIKBA_HUMANHPRD, IntAct14743216 details
MCM5_HUMANSSRP1_HUMANBioGRID, MINT16902406 21055985 details
MCM5_HUMANCRCM_HUMANIntAct17353931 details
MCM5_HUMANPHLA3_HUMANIntAct17353931 details
MCM5_HUMANAAKB1_HUMANIntAct17353931 details
MCM5_HUMANH4_HUMANBioGRID, IntAct19862764 25963833 details
MCM5_HUMANMCM6_HUMANBioGRID, UniProt11248027 17296731 22939629 25963833 26344197 details
MCM5_HUMANFKBP5_HUMANBioGRID, IntAct22863883 25036637 details
MCM5_HUMANMLF1_HUMANIntAct25036637 details
MCM5_HUMANMLF2_HUMANIntAct25036637 details
MCM5_HUMANHSF2_HUMANIntAct25036637 details
MCM5_HUMANBAG2_HUMANIntAct25036637 details
MCM5_HUMANNUDC3_HUMANIntAct25036637 details
MCM5_HUMANPSMD2_HUMANIntAct25036637 details
MCM5_HUMANCHIP_HUMANIntAct25036637 details
MCM5_HUMANCYBP_HUMANIntAct25036637 details
MCM5_HUMANPTG3L_HUMANIntAct25036637 details
MCM5_HUMANAASD1_HUMANIntAct25036637 details
MCM5_HUMANYBOX1_HUMANBioGRID, IntAct25497084 26343856 details
MCM5_HUMANLMBL1_HUMANBioGRID, DIP21149733 details
MCM5_HUMANMCM4_HUMANBioGRID11248027 22939629 26344197 details
MCM5_HUMANAIRE_HUMANBioGRID20085707 details
MCM5_HUMANHDAC5_HUMANBioGRID21081666 details
MCM5_HUMANTONSL_HUMANBioGRID21055985 details
MCM5_HUMANSH3K1_HUMANBioGRID19531213 details
MCM5_HUMANPNKP_HUMANBioGRID15385968 details
MCM5_HUMANITA4_HUMANBioGRID22623428 details
MCM5_HUMANTCEA1_HUMANBioGRID10454562 details
MCM5_HUMANGCR_HUMANBioGRID28611094 details
MCM5_HUMANFANCI_HUMANBioGRID25843623 details
MCM5_HUMANFACD2_HUMANBioGRID23993743 31180492 details
MCM5_HUMANCDC6_HUMANBioGRID23405012 details
MCM5_HUMANRECQ4_HUMANBioGRID19696745 29229926 details
MCM5_HUMANRFA1_HUMANBioGRID20679368 details
MCM5_HUMANCHK1_HUMANBioGRID25049228 details
MCM5_HUMANPLK1_HUMANBioGRID15654075 details
MCM5_HUMANBRD4_HUMANBioGRID31239290 32416067 details
MCM5_HUMAN1433G_HUMANHPRD15324660 details