Entity Details

Primary name MERL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35240
EntryNameMERL_HUMAN
FullNameMerlin
TaxID9606
Evidenceevidence at protein level
Length595
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesNF2

GO terms

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GOName
GO:0001707 mesoderm formation
GO:0001953 negative regulation of cell-matrix adhesion
GO:0003779 actin binding
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0006469 negative regulation of protein kinase activity
GO:0007398 ectoderm development
GO:0008285 negative regulation of cell population proliferation
GO:0014010 Schwann cell proliferation
GO:0014013 regulation of gliogenesis
GO:0016020 membrane
GO:0021766 hippocampus development
GO:0022408 negative regulation of cell-cell adhesion
GO:0030027 lamellipodium
GO:0030036 actin cytoskeleton organization
GO:0030336 negative regulation of cell migration
GO:0030864 cortical actin cytoskeleton
GO:0031527 filopodium membrane
GO:0031647 regulation of protein stability
GO:0032154 cleavage furrow
GO:0032587 ruffle membrane
GO:0035330 regulation of hippo signaling
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0042981 regulation of apoptotic process
GO:0043005 neuron projection
GO:0043409 negative regulation of MAPK cascade
GO:0044297 cell body
GO:0045177 apical part of cell
GO:0045216 cell-cell junction organization
GO:0045597 positive regulation of cell differentiation
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT
GO:0048471 perinuclear region of cytoplasm
GO:0051496 positive regulation of stress fiber assembly
GO:0051726 regulation of cell cycle
GO:0070306 lens fiber cell differentiation
GO:0072091 regulation of stem cell proliferation
GO:1900180 regulation of protein localization to nucleus
GO:2000177 regulation of neural precursor cell proliferation

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Cytoplasmic granule
Nucleus

Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000798 Ezrin/radixin/moesin-likeFamilyFamily
IPR008954 Moesin tail domain superfamilyFamilyHomologous superfamily
IPR011174 Ezrin/radixin/moesinFamilyFamily
IPR011259 Ezrin/radixin/moesin, C-terminalDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR014352 FERM/acyl-CoA-binding protein superfamilyFamilyHomologous superfamily
IPR018979 FERM, N-terminalDomainDomain
IPR018980 FERM, C-terminal PH-like domainDomainDomain
IPR019747 FERM conserved siteSiteConserved site
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR041789 ERM family, FERM domain C-lobeDomainDomain

Diseases

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Disease IDSourceNameDescription
101000 OMIMNeurofibromatosis 2 (NF2)Genetic disorder characterized by bilateral vestibular schwannomas (formerly called acoustic neuromas), schwannomas of other cranial and peripheral nerves, meningiomas, and ependymomas. It is inherited in an autosomal dominant fashion with full penetrance. Affected individuals generally develop symptoms of eighth-nerve dysfunction in early adulthood, including deafness and balance disorder. Although the tumors of NF2 are histologically benign, their anatomic location makes management difficult, and patients suffer great morbidity and mortality. The disease is caused by variants affecting the gene represented in this entry.
162091 OMIMSchwannomatosis 1 (SWNTS1)A cancer syndrome in which patients develop multiple non-vestibular schwannomas, benign neoplasms that arise from Schwann cells of the cranial, peripheral, and autonomic nerves. The disease is caused by variants affecting the gene represented in this entry.
156240 OMIMMesothelioma, malignant (MESOM)An aggressive neoplasm of the serosal lining of the chest. It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. The disease may be caused by variants affecting the gene represented in this entry.

Interactions

137 interactions

InteractorPartnerSourcesPublicationsLink
MERL_HUMANMED28_HUMANBioGRID, IntAct15467741 details
MERL_HUMANNHRF1_HUMANBioGRID, HPRD, IntAct15467741 26045165 9430655 details
MERL_HUMANGTPB4_HUMANIntAct17210637 details
MERL_HUMANSCHI1_HUMANBioGRID, HPRD, UniProt10669747 details
MERL_HUMANIQIP1_HUMANBioGRID, UniProt10669747 details
MERL_HUMANAMOT_HUMANBioGRID, IntAct, MINT19615732 21481793 23414517 24366813 24981860 26045165 26549023 32296183 33058421 34079125 details
MERL_HUMANAMOL2_HUMANBioGRID, IntAct21481793 24255178 26549023 32296183 33058421 details
MERL_HUMANM3K11_HUMANI2D20890305 details
MERL_HUMANMYPC2_HUMANBioGRID, IntAct23414517 details
MERL_HUMANKDM1A_HUMANBioGRID, IntAct, MINT23455924 32814053 34079125 details
MERL_HUMANLATS1_HUMANBioGRID, IntAct24012335 26045165 33058421 34079125 details
MERL_HUMANMERL_HUMANBioGRID, HPRD, IntAct11779178 11856822 15467741 24012335 28205554 28514442 9537418 details
MERL_HUMANBYST_HUMANBioGRID, IntAct32296183 details
MERL_HUMANTXLNB_HUMANBioGRID, IntAct32296183 details
MERL_HUMANEMD_HUMANBioGRID, IntAct26549023 32296183 details
MERL_HUMANDCAF1_HUMANBioGRID, HPRD, IntAct18332868 20178741 21750658 24912773 26549023 28514442 33058421 details
MERL_HUMANBKRB1_HUMANBioGRID, MINT28298427 details
MERL_HUMANHGS_HUMANBioGRID, HPRD, IntAct10861283 11285248 11779178 12444101 12444102 29997244 31467278 32814053 details
MERL_HUMANEIF3C_HUMANIntAct11779178 details
MERL_HUMANSPTB2_HUMANBioGRID, HPRD, IntAct11535133 11779178 9537418 details
MERL_HUMANSEM1_HUMANIntAct32814053 details
MERL_HUMANZKSC8_HUMANIntAct32814053 details
MERL_HUMANZNF20_HUMANIntAct32814053 details
MERL_HUMANVHL_HUMANIntAct32814053 details
MERL_HUMANTSNAX_HUMANIntAct32814053 details
MERL_HUMANTERF1_HUMANIntAct32814053 details
MERL_HUMANNVL_HUMANIntAct32814053 details
MERL_HUMANEED_HUMANIntAct32814053 details
MERL_HUMANEIF3F_HUMANIntAct32814053 details
MERL_HUMANPIAS1_HUMANIntAct32814053 details
MERL_HUMANCSN3_HUMANIntAct32814053 details
MERL_HUMANKT33B_HUMANIntAct32814053 details
MERL_HUMANKC1D_HUMANIntAct32814053 details
MERL_HUMANCBLB_HUMANIntAct32814053 details
MERL_HUMANBEX5_HUMANIntAct32814053 details
MERL_HUMANVSX2_HUMANIntAct32814053 details
MERL_HUMANCL074_HUMANIntAct32814053 details
MERL_HUMANRUFY4_HUMANIntAct32814053 details
MERL_HUMANFAM9A_HUMANIntAct32814053 details
MERL_HUMANZN497_HUMANIntAct32814053 details
MERL_HUMANTRI69_HUMANIntAct32814053 details
MERL_HUMANASB9_HUMANIntAct32814053 details
MERL_HUMANRN183_HUMANIntAct32814053 details
MERL_HUMANVP37A_HUMANIntAct32814053 details
MERL_HUMANZN572_HUMANIntAct32814053 details
MERL_HUMANPIHD2_HUMANIntAct32814053 details
MERL_HUMANMPND_HUMANIntAct32814053 details
MERL_HUMANLNX1_HUMANIntAct32814053 details
MERL_HUMANSPT22_HUMANIntAct32814053 details
MERL_HUMANABLM2_HUMANIntAct32814053 details
MERL_HUMANZN436_HUMANIntAct32814053 details
MERL_HUMANTNIP3_HUMANIntAct32814053 details
MERL_HUMANTUT7_HUMANIntAct32814053 details
MERL_HUMANOTU7B_HUMANIntAct32814053 details
MERL_HUMANOTUB1_HUMANIntAct32814053 details
MERL_HUMANRN138_HUMANIntAct32814053 details
MERL_HUMANATLA1_HUMANIntAct32814053 details
MERL_HUMANDCAF8_HUMANIntAct32814053 details
MERL_HUMANSCAPE_HUMANIntAct32814053 details
MERL_HUMANNSMF_HUMANIntAct32814053 details
MERL_HUMANRYBP_HUMANIntAct32814053 details
MERL_HUMANSNW1_HUMANIntAct32814053 details
MERL_HUMANEMIL1_HUMANIntAct32814053 details
MERL_HUMANNEBL_HUMANIntAct32814053 details
MERL_HUMANCHIP_HUMANIntAct32814053 details
MERL_HUMANSGSM3_HUMANBioGRID, HPRD15541357 details
MERL_HUMANEZRI_HUMANBioGRID, HPRD10036239 17891137 details
MERL_HUMANPAXI_HUMANBioGRID, HPRD12118253 details
MERL_HUMANSDCB1_HUMANBioGRID, HPRD11432873 details
MERL_HUMANAKT1_HUMANBioGRID17891137 21750658 28205554 details
MERL_HUMANAGAP2_HUMANBioGRID17891137 details
MERL_HUMANCD44_HUMANBioGRID, HPRD12356905 17891137 19351837 24912773 28205554 details
MERL_HUMANPYGO2_HUMANBioGRID20937768 details
MERL_HUMANCIP1_HUMANBioGRID16532029 details
MERL_HUMANLATS2_HUMANBioGRID24012335 26045165 28205554 29183995 details
MERL_HUMANKPCA_HUMANBioGRID21750658 details
MERL_HUMANNOP53_HUMANBioGRID21167305 details
MERL_HUMANEGFR_HUMANBioGRID25043298 28205554 details
MERL_HUMANBECN1_HUMANBioGRID28205554 details
MERL_HUMANCBLC_HUMANBioGRID28205554 details
MERL_HUMANGLIS2_HUMANBioGRID28205554 details
MERL_HUMANERD22_HUMANBioGRID28205554 details
MERL_HUMANMP2K5_HUMANBioGRID28205554 details
MERL_HUMANARNT_HUMANBioGRID28205554 details
MERL_HUMANAURKA_HUMANBioGRID28205554 details
MERL_HUMANCCND2_HUMANBioGRID28205554 details
MERL_HUMANCCNE1_HUMANBioGRID28205554 details
MERL_HUMANCDK4_HUMANBioGRID28205554 details
MERL_HUMANCDK6_HUMANBioGRID28205554 details
MERL_HUMANCDN2B_HUMANBioGRID28205554 details
MERL_HUMANCDN2C_HUMANBioGRID28205554 details
MERL_HUMANEPHA2_HUMANBioGRID28205554 details
MERL_HUMANFGFR4_HUMANBioGRID28205554 details
MERL_HUMANMP2K3_HUMANBioGRID28205554 details
MERL_HUMANMYC_HUMANBioGRID28205554 details
MERL_HUMANSTK11_HUMANBioGRID28205554 details
MERL_HUMANTERT_HUMANBioGRID28205554 details
MERL_HUMANTSC1_HUMANBioGRID, HPRD12226091 28205554 details
MERL_HUMANPGFRA_HUMANBioGRID28205554 details
MERL_HUMANRAF1_HUMANBioGRID28205554 details
MERL_HUMANRASF1_HUMANBioGRID28205554 details
MERL_HUMANP53_HUMANBioGRID28205554 details
MERL_HUMANTTYH2_HUMANBioGRID28205554 details
MERL_HUMANARAF_HUMANBioGRID28205554 details
MERL_HUMANDACH1_HUMANBioGRID28205554 details
MERL_HUMANFZR1_HUMANBioGRID28205554 details
MERL_HUMANGRM1_HUMANBioGRID28205554 details
MERL_HUMANHGF_HUMANBioGRID28205554 details
MERL_HUMANMK14_HUMANBioGRID28205554 details
MERL_HUMANERBB2_HUMANBioGRID, HPRD12118253 28205554 details
MERL_HUMANHIF1A_HUMANBioGRID28205554 details
MERL_HUMANIGF1R_HUMANBioGRID28205554 details
MERL_HUMANKAT2A_HUMANBioGRID28205554 details
MERL_HUMANM3K5_HUMANBioGRID28205554 details
MERL_HUMANMDM4_HUMANBioGRID28205554 details
MERL_HUMANMET_HUMANBioGRID28205554 details
MERL_HUMANSOX3_HUMANBioGRID28205554 details
MERL_HUMANSOX4_HUMANBioGRID28205554 details
MERL_HUMANEIF3B_HUMANBioGRID32296183 details
MERL_HUMANGNDS_HUMANHPRD16007223 details
MERL_HUMANINADL_HUMANIntAct21481793 28514442 details
MERL_HUMANPAK1_HUMANHPRD, IntAct11719502 14580336 21481793 details
MERL_HUMANAMOL1_HUMANBioGRID, IntAct, MINT21481793 24366813 24981860 26549023 28514442 33058421 details
MERL_HUMANSOS1_HUMANBioGRID10675333 details
MERL_HUMANDDB1_HUMANBioGRID18332868 20178741 26549023 33058421 details
MERL_HUMANCUL4A_HUMANBioGRID18332868 20178741 details
MERL_HUMANRIT1_HUMANBioGRID18332868 details
MERL_HUMANKIBRA_HUMANBioGRID21233212 details
MERL_HUMANCSN1_HUMANBioGRID22414063 details
MERL_HUMANKSR1_HUMANBioGRID26549023 details
MERL_HUMANFAK1_HUMANBioGRID27736841 details
MERL_HUMANNED4L_HUMANBioGRID33058421 details
MERL_HUMANCUL4B_HUMANBioGRID33058421 details
MERL_HUMANHUWE1_HUMANBioGRID33058421 details
MERL_HUMANXPO1_HUMANHPRD12217955 details
MERL_HUMANCTNB1_HUMANHPRD12695331 details
MERL_HUMANTRBP2_HUMANHPRD15123692 details